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List of works by John R Perfect

"Is there an emerging need for new antifungals?".

scientific article

A Chronological History of the International Conference on Cryptococcus and Cryptococcosis (ICCC), an Invaluable Forum for Growth of the Cryptococcal Research Field and Clinical Practice ⬇️

scientific article published on October 29, 2011

A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

article

A meta-analysis of medical versus surgical therapy for Candida endocarditis

scientific article

A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.

scientific article

AIDS-related mycoses: the way forward

scientific article

AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

scientific article published on 17 June 2015

Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations ⬇️

scientific article published on August 17, 2011

Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans

scientific article published on February 2002

Aerosolized antifungal prophylaxis: the winds of change?

scientific article published in May 2008

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

scientific article

An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.

scientific article

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation

scientific article

Antifungal pharmacotherapy for invasive mould infections

scientific article

Antifungal resistance: the clinical front.

scientific article

Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update

scientific article published on 24 March 2009

Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact

scientific article published on January 2008

Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy ⬇️

scientific article published on January 1, 2002

Approaches to Antifungal Therapies and Their Effectiveness among Patients with Cryptococcosis ⬇️

scientific article published on March 11, 2013

Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis

scientific article published on 27 February 2009

Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole

scientific article published on March 2004

Azole antifungals: 35 years of invasive fungal infection management

scientific article published on 05 April 2015

Black Molds and Melanized Yeasts Pathogenic to Humans

scientific article

Blood gene expression signatures predict invasive candidiasis

scientific article

Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier

scientific article

Breakthrough invasive candidiasis in patients on micafungin

scientific article

CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.

scientific article published on January 2016

Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

scientific article

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

scientific article published on 14 May 2007

Calcineurin is essential for Candida albicans survival in serum and virulence

scientific article

Calcineurin is essential for survival during membrane stress in Candida albicans

scientific article

Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus

scientific article published on 2 May 2008

Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD).

scientific article published in January 2004

Candida glabrata endophthalmitis following penetrating keratoplasty

scientific article published on 01 March 2009

Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole

scientific article

Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation

scientific article published in July 2003

Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence

scientific article published in November 2005

Cases of disseminated cryptococcosis in intravenous drug abusers without HIV infection: A new risk factor?

scientific article published on 2 December 2016

Caspofungin for invasive candidiasis at a tertiary care medical center

scientific article published on November 2006

Caspofungin: first approved agent in a new class of antifungals ⬇️

scientific article published on May 1, 2003

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

scientific article

Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy

scientific article published in August 2003

Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans

scientific article published on October 2006

Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study

scientific article

Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.

scientific article

Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.

scientific article published on 13 September 2006

Combination antifungal therapy

scientific article published on 01 March 2004

Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana

scientific article published on 7 July 2015

Comparative evaluation of Etest and sensititre yeastone panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents

scientific article published on 3 January 2007

Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients

scientific article published in January 2004

Comparing outcomes of early, late, and non-surgical management of intraspinal abscess

scientific article published on 8 November 2016

Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant ⬇️

scientific article published on August 24, 2012

Comparison of caspofungin and amphotericin B for invasive candidiasis

scientific article

Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest

scientific article

Correction to Molecular Umbrella-Amphotericin B Conjugates

scientific article published on 30 September 2015

Correction: Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant

scientific article

Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options ⬇️

scientific article published on October 1, 2012

Cost-effectiveness of posaconazole versus fluconazole for prevention of invasive fungal infections in U.S. patients with graft-versus-host disease.

scientific article published in January 2012

Cost-effectiveness of posaconazole versus fluconazole or itraconazole in the prevention of invasive fungal infections among neutropenic patients in the United States.

scientific article

Cryptococcosis

scientific article published in March 2016

Cryptococcosis

scientific article published on 01 December 2002

Cryptococcosis

scientific article published on 01 September 2006

Cryptococcosis diagnosis and treatment: What do we know now

scientific article

Cryptococcosis in solid organ transplant recipients: current state of the science

scientific article

Cryptococcosis: a model for the understanding of infectious diseases

scientific article published on 17 April 2014

Cryptococcus gattii genotype VGI infection in New England

scientific article published on December 2011

Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver island outbreak strains

scientific article

Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals ⬇️

scientific article published on June 1, 2011

Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms

scientific article

Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence

scientific article published on 07 August 2004

Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth

scientific article

Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier

scientific article

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host ⬇️

scientific article

Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection

scientific article

Cryptococcus neoformans: a sugar-coated killer with designer genes

scientific article

Cryptococcus neoformans: the yeast that likes it hot.

scientific article

Curious Crosses: Injection-Induced Lesions

scientific article published on 9 September 2016

Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.

scientific article

Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study

scientific article published on 5 December 2011

Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria

scientific article published on September 2008

Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner

scientific article

Dematiaceous Fungi Mimicking a Conjunctival Melanoma ⬇️

scientific article published on 01 March 2013

Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients

scientific article published in October 2004

Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus

scientific article published on 17 November 2008

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production

scientific article

Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib

scientific article

Drug resistance in Cryptococcus neoformans.

scientific article

Early treatment of candidemia in adults: a review

scientific article published on 06 September 2010

Efficacy of Oral APX001 in a Murine Model of Cryptococcal Meningitis

scientific article published on 4 October 2017

Efficient, Cost-Effective, High-Throughput, Multilocus Sequencing Typing (MLST) Method, NGMLST, and the Analytical Software Program MLSTEZ.

scientific article published on January 2017

Efficiently Killing a Sugar-Coated Yeast ⬇️

scientific article published on 01 April 2013

Emergence of the Molds Other than Aspergillus in Immunocompromised Patients

scientific article published on 2 June 2017

Emerging echinocandins for treatment of invasive fungal infections

scientific article

Evaluation and management of fungal infections in immunocompromised patients

scientific article

Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain

scientific article published on 01 February 2005

Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis

scientific article published on 20 March 2017

Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease

scientific article published on 12 October 2016

Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target

scientific article published on 13 August 2007

First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen

scientific article

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

scientific article published on January 2013

Fungal Infections of the Bones and Joints.

scientific article

Fungal diagnosis: how do we do it and can we do better?

scientific article published on April 2013

Fungi that Infect Humans

scientific article published on June 2017

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System

scientific article published on 21 December 2021

Genetic Susceptibility to Fungal Infections: What is in the Genes?

scientific article published on 29 March 2016

Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia

scientific article

Genomic characterization of recurrent mold infections in thoracic transplant recipients

scholarly article by Julia A Messina et al published October 2018 in Transplant Infectious Disease

Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans

scientific article published on August 2004

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

scholarly article

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

scientific article published on June 2007

Host Defenses Against Cryptococcosis ⬇️

scientific article published on January 1, 2011

How Clean Is the Linen at My Hospital? The Mucorales on Unclean Linen Discovery Study of Large United States Transplant and Cancer Centers

scientific article published in 2018

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin

scientific article

Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling

scientific article published on 26 March 2009

Human dectin-1 deficiency and mucocutaneous fungal infections

scientific article

Human genetic susceptibility to Candida infections.

scientific article published on 04 June 2012

Iatrogenic Fungal Meningitis: Tragedy Repeated

scientific article published on 01 December 2012

Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans ⬇️

scientific article published on October 1, 2003

Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray

scientific article published on October 2004

Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System ⬇️

scientific article published on September 20, 2012

Immune reconstitution syndrome and exacerbation of infections after pregnancy

scientific article published on 21 September 2007

Immune reconstitution syndrome associated with opportunistic mycoses

scientific article published on June 2007

Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance

scientific article

Immunology of infection caused by Cryptococcus neoformans

scientific article

Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis

scientific article

In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.

scientific article published on 27 July 2018

In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection

scientific article published in September 2004

In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus

scientific article published on May 2004

In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients

scientific article published on December 2004

Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases

scientific article

Inkjet Printing of Amphotericin B onto Biodegradable Microneedles Using Piezoelectric Inkjet Printing

scholarly article by Ryan D. Boehm et al published 22 February 2013 in JOM

Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species

scientific article published on August 2004

Intracellular Action of a Secreted Peptide Required for Fungal Virulence

scientific article

Invasive mould infections: a multi-disciplinary update

scientific article published on January 2009

Invasive mycoses: evolving challenges and opportunities in antifungal therapy (multimedia activity)

scientific article published on 01 October 2011

Invasive mycoses: evolving challenges and opportunities in antifungal therapy. Introduction

scientific article published on 01 January 2012

Is it time to abandon the use of amphotericin B bladder irrigation?

scientific article

Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses

scientific article published on 11 May 2016

Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species.

scientific article

Isavuconazole for treatment of rare invasive fungal diseases.

scientific article

Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial.

scientific article published on 23 March 2018

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis

scientific article

Liposomal amphotericin B: clinical experience and perspectives

scientific article

Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion

scientific article

Management of cryptococcosis: how are we doing?

scientific article

Management of invasive mycoses in hematology patients: current approaches.

scientific article

Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans

scientific article

Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

scientific article published on 30 July 2008

Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii

scientific article published on 07 March 2017

Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens

scientific article published on 12 March 2010

Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis

scientific article

Molecular umbrella-amphotericin B conjugates

scientific article

Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients

scientific article published in October 2009

Mucormycosis Rhinosinusitis at Diagnosis of Acute Lymphoblastic Leukemia: Diagnostics and Management Challenges in a Low-Middle-income Country

scientific article published on April 2015

New antifungal agents

scientific article

Newer antifungal therapy for emerging fungal pathogens

scientific article

Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing

scientific article

Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species

scientific article published on 23 August 2013

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

scientific article published on August 2017

Novel modes of antifungal drug administration

scientific article published in August 2004

Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis

scientific article

Outcome of lung transplantation in patients with mycetomas

scientific article published in January 2002

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

scientific article

Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans

scientific article published on 13 October 2006

Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients.

scientific article published on 18 April 2013

Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints

scientific article published on 09 April 2013

Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers

scientific article published on 11 May 2009

Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia

scientific article

Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis

scientific article

Phenotypic Variability Correlates with Clinical Outcome in Isolates Obtained from Botswanan HIV/AIDS Patients

article

Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil

scientific article published in November 2005

Phenotypic variability correlates with clinical outcome in Cryptococcus isolates obtained from Botswanan HIV/AIDS patients

article

Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus

scientific article published on 21 July 2006

Plasminogen alleles influence susceptibility to invasive aspergillosis

scientific article

Pleiotropic Effects of Deubiquitinating Enzyme Ubp5 on Growth and Pathogenesis of Cryptococcus neoformans ⬇️

scientific article published on June 14, 2012

Polyhexamethylene Biguanide and Calcineurin Inhibitors as Novel Antifungal Treatments forAspergillusKeratitis ⬇️

scientific article published on September 21, 2011

Population Genomics Of Cryptococcus neoformans var. grubii Reveals New Biogeographic Relationships And Finely Maps Hybridization

scientific article published in May 2017

Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by

scientific article published in 2019

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

scientific article

Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant

scientific article published on September 2008

Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans

scientific article

Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia

scientific article

Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update

scientific article published on March 2009

Predictors and outcomes of Candida bloodstream infection: eight-year surveillance, western Saudi Arabia

scientific article published on 25 January 2014

Present and Future Therapy of Infections

Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States

scientific article published on 15 December 2017

Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts

scientific article published on 2 January 2007

Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients

scientific article published on 01 July 2007

Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain

scientific article published on 8 January 2007

QTc Prolongation in Patients Receiving Triazoles and Amiodarone.

scientific article

Quantitation of Candida CFU in initial positive blood cultures

scientific article

Rare and emerging fungal pulmonary infections

scientific article published on April 2008

Real-Time Treatment Guidelines: Considerations during the Exserohilum rostratum Outbreak in the United States ⬇️

scientific article published on February 5, 2013

Recent advances in antifungal pharmacotherapy for invasive fungal infections

scientific article published in April 2004

Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia

scientific article

Recent advances in the treatment of life-threatening, invasive fungal infections

scientific article

Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment

scientific article published in April 2003

Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans

scientific article

Repeated therapeutic lumbar punctures in cryptococcal meningitis - necessity and/or opportunity?

scientific article published on 6 September 2016

Reply to Argüelles

scientific article published on 5 August 2016

Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/

scientific article published on June 2008

Risk factors for mortality in patients with mucormycosis ⬇️

scientific article published on March 21, 2012

Risk of Fungemia Due to Rhodotorula and Antifungal Susceptibility Testing of Rhodotorula Isolates ⬇️

scientific article published on November 1, 2003

Role of Alternative Oxidase Gene in Pathogenesis of Cryptococcus neoformans ⬇️

scientific article published on October 1, 2003

Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production

scientific article

Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients

scientific article published in October 2002

Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.

scientific article published on 8 May 2006

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

scientific article published in Nature

Scedosporium apiosermum infection of the "Native" valve: Fungal endocarditis in an orthotopic heart transplant recipient

scientific article published on 30 July 2015

Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide

scientific article

Schistosoma haematobium in urine: morphology with ThinPrep method

scientific article published on 01 October 2007

Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates

scientific article published on September 2003

Simple Strategy for Taming Membrane-Disrupting Antibiotics

scientific article

Status of medical mycology education

scientific article published on December 2003

Strategies to manage antifungal drug resistance ⬇️

scientific article published on February 1, 2011

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

scientific article

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

scientific article published on 15 June 2016

Successful use of amphotericin B lipid complex in the treatment of cryptococcosis

scientific article

Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages

scientific article

Surfactant Protein D Facilitates Cryptococcus neoformans Infection ⬇️

scientific article published on April 30, 2012

Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival

scientific article

Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis

scientific article published on 9 August 2010

T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation

scientific journal article

Taming Amphotericin B.

scientific article published on 4 September 2015

Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model

scientific article

Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.

scientific article

The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation

scientific article

The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis

scientific article (publication date: 11 January 2017)

The Cryptococcus neoformans catalase gene family and its role in antioxidant defense

scientific article

The Cryptococcus neoformans transcriptome at the site of human meningitis

scientific article published on 04 February 2014

The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial ⬇️

scientific article published on September 20, 2011

The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance

scientific article

The Impact of the Host on Fungal Infections ⬇️

scientific article published on January 1, 2012

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

scientific article published on 13 January 2015

The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host ⬇️

scientific article published on July 10, 2012

The antifungal pipeline: a reality check

scientific article

The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans

scientific article

The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis).

scientific article published on November 2016

The economic costs to United States hospitals of invasive fungal infections in transplant patients ⬇️

scientific article published on October 20, 2010

The spectrum of fungi that infects humans

scientific article

The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii

scientific article

The war on cryptococcosis: A Review of the antifungal arsenal.

scientific article

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.

scientific article published on 18 May 2018

Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.

scientific article published on February 2012

Transcriptional Profiles Elucidate Differential Host Responses to Infection with <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i>

scientific article published on 22 April 2022

Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin

scientific article

Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial

scientific article

Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex

scientific article

Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

scientific article

Trehalose pathway as an antifungal target

scientific article published on June 2016

Update on epidemiology of and preventive strategies for invasive fungal infections in cancer patients

scientific article

Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion

scientific article

Use of Antifungal Combination Therapy: Agents, Order, and Timing

scientific article published on May 2010

Use of newer antifungal therapies in clinical practice: what do the data tell us?

scientific article

Value of an inhalational model of invasive aspergillosis.

scientific article published in October 2004

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.

scientific article

Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis

scientific article

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.

scientific article

Voriconazole Treatment for Less‐Common, Emerging, or Refractory Fungal Infections ⬇️

scientific article published on April 22, 2003

Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever

scientific article (publication date: 24 January 2002)

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children

scientific article

When primary antifungal therapy fails

scientific article published on May 2008

β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study

scientific article

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