List of works - Wei Qi

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

scientific article published on 01 June 2018

Absolute quantification of histone PTM marks by MRM-based LC-MS/MS.

scientific article published on 8 September 2014

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.

scientific article published on 30 January 2017

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.

scientific article published on 15 March 2017

Cholesterol transport through lysosome-peroxisome membrane contacts

scientific journal article

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors.

scientific article

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

scientific article published in Nature Communications

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

scientific article

Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance

scientific article published on 06 May 2019

Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.

scientific article

Identification of two novel components of the human NDC80 kinetochore complex

scientific article

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

scientific article

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

scientific article

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1

scientific article

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase

scientific article published on 19 July 2019

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

scientific article

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

scientific article

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

scientific article

The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.

scientific article

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

scientific article

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

scientific article

List of works by Wei Qi

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

Absolute quantification of histone PTM marks by MRM-based LC-MS/MS.

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.

Cholesterol transport through lysosome-peroxisome membrane contacts

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors.

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance

Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.

Identification of two novel components of the human NDC80 kinetochore complex

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase