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List of works by Carole Ober

(Too) great expectations: the challenges in replicating asthma disease genes

scientific article published on June 2009

116 Genome-Wide Association Studies of Asthma Indicate Opposite Immunopathogenesis Direction From Autoimmune Diseases.

scientific article published on 17 February 2012

A LASSO penalized regression approach for genome-wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data

scientific article

A common cortactin gene variation confers differential susceptibility to severe asthma

scientific article published on December 2008

A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites

scientific article

A common variant associated with prostate cancer in European and African populations

scientific article published on 7 May 2006

A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults

scientific article published on April 2015

A comparison of humans and baboons suggests germline mutation rates do not track cell divisions

scientific article published on 17 August 2020

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

scientific article published on 11 October 2016

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.

scientific article published on 4 January 2018

A genome-wide screen for hyposmia susceptibility Loci

scientific article published on 02 February 2008

A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity

scientific article published on 01 January 2006

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes

scientific article

A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.

scientific article

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

scientific article published on 10 November 2012

A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12.

scientific article

A novel NDUFS4 frameshift mutation causes Leigh disease in the Hutterite population

scientific article published on 27 September 2016

A population-based study of autosomal-recessive disease-causing mutations in a founder population

scientific article

A shared founder mutation underlies restrictive dermopathy in Old Colony (Dutch-German) Mennonite and Hutterite patients in North America

scientific article published on 11 April 2012

A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans

scientific article published on 01 May 2007

Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals

scientific article published on 28 March 2012

Allele-Specific Targeting of microRNAs to HLA-G and Risk of Asthma

article

Allele-specific targeting of microRNAs to HLA-G and risk of asthma

scientific article

Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma

scientific article published on March 2016

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos

scientific article published on 07 September 2018

An estimate of the average number of recessive lethal mutations carried by humans

scientific article

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes ⬇️

scientific journal article

Are common disease susceptibility alleles the same in outbred and founder populations?

scientific article published on 01 July 2004

Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes.

scientific article published on 13 February 2017

Association studies for asthma and atopic diseases: a comprehensive review of the literature

scientific article

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

scientific article published on 20 February 2019

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Asthma Genetics in the Post-GWAS Era.

scientific article published on March 2016

Asthma genetics 2006: the long and winding road to gene discovery.

scientific article

Author Correction: Assembly of a pan-genome from deep sequencing of 910 humans of African descent

scientific article published on 01 February 2019

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scientific article published on 01 September 2018

Best linear unbiased allele-frequency estimation in complex pedigrees

scientific article

Blood groups in the species survival plan®, European endangered species program, and managed in situ populations of bonobo (Pan paniscus), common chimpanzee (Pan troglodytes), gorilla (Gorilla ssp.), and orangutan (Pongo pygmaeus ssp.) ⬇️

scientific article published on September 17, 2010

Broad-scale recombination patterns underlying proper disjunction in humans

scientific article published on 18 September 2009

CDHR3 Genetics and Rhinovirus C Respiratory Illnesses

scientific article published on 9 November 2017

CFTR mutations and reproductive outcomes in a population isolate

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2

Colloquium papers: Heritability of reproductive fitness traits in a human population

scientific article

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

scientific journal article

Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness

scientific article

Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production

scientific article

DNA methylation in lung cells is associated with asthma endotypes and genetic risk

scientific article published on 08 December 2016

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes.

scientific article published on 8 May 2018

Development of a diagnostic DNA chip to screen for 30 autosomal recessive disorders in the Hutterite population

scientific article published on 19 January 2016

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Disclosure of genetic research results to members of a founder population

scientific article

Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?

scientific article published in April 2004

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

scientific article

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes.

scientific article published on 18 March 2010

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function

scientific article

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies

scientific article published on 06 July 2018

Effects of dog ownership and genotype on immune development and atopy in infancy

scientific article published in February 2004

Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.

scientific article

Empirical data about women's attitudes toward a biobank focused on pregnancy outcomes

scientific article published on 01 February 2008

Empirical data about women's attitudes towards a hypothetical pediatric biobank

scientific article published on 01 February 2008

Epigenome-Wide Association Study of DNA Methylation and Adult Asthma in the Agricultural Lung Health Study

scientific article published on 07 May 2020

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

scientific article published on 20 December 2016

Estimating the human mutation rate using autozygosity in a founder population

scientific article

Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma

scientific article

Evaluating the evidence for transmission distortion in human pedigrees

scientific article published on 29 February 2012

Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry

scientific article published on 25 April 2019

Evidence for extensive transmission distortion in the human genome

scientific article

Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure

scientific article published on April 2003

Evidence of balancing selection at the HLA-G promoter region

scientific article published on 19 October 2005

Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss

scientific article

Evolutionary genetics of the human Rh blood group system

scientific article

Exome sequencing and the genetics of intellectual disability.

scientific article

Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13

scientific article

Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes

scientific article

Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21

scientific article

Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci

scientific article published on 09 June 2006

Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13

scientific article published on 01 June 2008

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

scientific article

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

scientific article

Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility

scientific article

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans

scientific article published on 4 October 2012

Future Research Directions in Asthma. An NHLBI Working Group Report

scientific article

Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma

scholarly article by Damien C Croteau-Chonka et al published 25 October 2018 in Obesity

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

scientific article published on 5 August 2016

Gene co-expression networks in whole blood implicate multiple interrelated molecular pathways in obese asthma

article

Gene-environment interaction effects on the development of immune responses in the 1st year of life

scientific article

Gene-environment interactions in human disease: nuisance or opportunity?

scientific article

Genetic Determinants of the Gut Microbiome in UK Twins

scientific article published on May 2016

Genetic associations with viral respiratory illnesses and asthma control in children.

scientific article

Genetic studies of stuttering in a founder population

scientific article

Genetic variance components estimation for binary traits using multiple related individuals

scientific article published on 4 April 2011

Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy

scientific article published in March 2004

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search

scientific article published on 01 January 2018

Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)

scientific article published on 01 May 2004

Genome-Wide Association Studies of the Human Gut Microbiota

scientific article published on 3 November 2015

Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease

scientific article

Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways

scientific article published on 16 October 2015

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects

scientific article

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scholarly article by Johannes Waage et al published August 2018 in Nature Genetics

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases

scientific article published on 12 June 2012

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos

scientific article published on 6 December 2014

Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin

scientific article

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

scientific article published in April 2007

Genome-wide association study identifies candidate genes for male fertility traits in humans

scientific article

Genome-wide association study of lung function phenotypes in a founder population

scientific article

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q

scientific article

Genome-wide association study of recalcitrant atopic dermatitis in Korean children

scientific article

Genome-wide interaction studies reveal sex-specific asthma risk alleles

scientific article

Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report

scientific article

Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes.

scientific article published on 9 May 2018

HLA-G and immune tolerance in pregnancy

scientific article

HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq

scientific article

HLA-G: an asthma gene on chromosome 6p

scientific article published on 01 November 2005

Heritability estimation and differential analysis of count data with generalized linear mixed models in genomic sequencing studies

scientific article published on 01 February 2019

Heritability estimation of sex-specific effects on human quantitative traits

scientific article published in May 2007

High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans

scientific article published on 31 January 2008

High-resolution two-dimensional electrophoretic survey of serum protein genetic types in Schmiedeleut Hutterites

scientific article

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population

scientific article

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

scientific article published on February 2017

Host genetic variation influences gene expression response to rhinovirus infection

scientific article

Human body scents: conscious perceptions and biological effects

scientific article

Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1.

scientific article

IFNG genotype and sex interact to influence the risk of childhood asthma

scientific article published on 27 July 2011

ITGB3 shows genetic and expression interaction with SLC6A4.

scientific article published on 24 May 2006

Immune development and environment: lessons from Amish and Hutterite children

scientific article

Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia

scientific article

Inheritance of most X-linked traits is not dominant or recessive, just X-linked

scientific article

Innate Immunity and Asthma Risk

scientific article published on November 2016

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

scientific article

Integrated analyses of gene expression and genetic association studies in a founder population

scientific article published on 29 February 2016

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis

scientific article

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene

scientific article (publication date: 2013)

Integrin β3 genotype influences asthma and allergy phenotypes in the first 6 years of life

article

Intellectual disability associated with a homozygous missense mutation in THOC6

scientific article

Inverted duplications on acentric markers: mechanism of formation

scientific article published on 31 March 2009

Lessons Learned From GWAS of Asthma.

scientific article published in March 2019

Leveraging gene-environment interactions and endotypes for asthma gene discovery

scientific article published on March 2016

Linkage analysis with dense SNP maps in isolated populations

scientific article published on 9 April 2009

Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution.

scientific article published in May 2002

Loneliness is associated with sleep fragmentation in a communal society

scientific article

Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels

scientific article published on 30 September 2020

Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree

scientific article published on 01 January 2003

Matching two independent cohorts validates DPH1 as a gene responsible for autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies

scientific article

Maternal asthma and microRNA regulation of soluble HLA-G in the airway

scientific article published on 25 March 2013

Maternal microchimerism protects against the development of asthma

scientific article

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

scientific article

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

scientific article published on 19 October 2015

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals

scientific article published on September 2005

Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile

scientific article

Nasal Microbiome Composition Is Associated with Chitotriosidase (Chit1) Activity in Adult Hutterites

scientific article published on March 2016

Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma

scientific article

Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma

scientific article published on May 2015

Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus

scientific article

PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population

scientific article

Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions

scientific article published in PLoS ONE

Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree

Paternally inherited HLA alleles are associated with women's choice of male odor

scientific article

Pathogenic Variant in ACTB, p.Arg183Trp, Causes Juvenile-Onset Dystonia, Hearing Loss, and Developmental Delay without Midline Malformation

scientific article published on 12 April 2017

Perspectives on the past decade of asthma genetics

scientific article published on 01 August 2005

Positive selection on human gamete-recognition genes

scientific article published on 11 January 2018

Pregnancy outcome in recurrent miscarriage patients with skewed X chromosome inactivation

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation

scientific article

Present status on the genetic studies of asthma

scientific article

Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites

scientific article published on 04 March 2002

Rare non-coding variants are associated with plasma lipid traits in a founder population

scientific article published on 27 November 2017

Recessive TRAPPC11 mutations cause a disease spectrum of limb girdle muscular dystrophy and myopathy with movement disorder and intellectual disability

scientific article published on 03 July 2013

Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9.

scientific article

Resequencing candidate genes implicates rare variants in asthma susceptibility

scientific article published on February 2012

Response to correspondence of NDUFS4-related Leigh syndrome in Hutterites.

scientific article

Rethinking genetic models of asthma: the role of environmental modifiers

scientific article

Rhinovirus wheezing illness and genetic risk of childhood-onset asthma

scientific article published on 27 March 2013

Rising prevalence of asthma is sex-specific in a US farming population

scientific article

Risky Business: Meeting the Structural Needs of Transdisciplinary Science

scientific article published in December 2017

Seasonal variation in human gut microbiome composition

scientific article

Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians.

scientific article published on January 2011

Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy

scientific article published in March 2003

Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors

scientific article published on January 2010

Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility

scientific article published on December 2009

Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women

scientific article published on 7 June 2005

Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population

scientific article published on 01 May 2006

Sex-specific genetic architecture of human disease

scientific article published on December 2008

Sex-specific genetic architecture of whole blood serotonin levels

scientific article

Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans

scientific article

Shared and distinct genetic risk factors for childhood onset and adult onset asthma

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies

scientific article published on 27 April 2019

Stress and Bronchodilator Response in Children with Asthma

scientific article published in July 2015

TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone

scientific article

Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells

scientific article

Testing for Hardy-Weinberg equilibrium in samples with related individuals

scientific article

The ABO blood group is a trans-species polymorphism in primates

scientific article

The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate

scientific article

The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population

scientific article published on 10 June 2019

The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases

scientific article

The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes

scientific article

The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines

scientific article

The effects of EBV transformation on gene expression levels and methylation profiles ⬇️

scientific article published on February 2, 2011

The effects of EBV transformation on gene expression levels and methylation profiles.

scientific article published on 20 February 2012

The genetics of asthma and allergic disease: a 21st century perspective

scientific article

The maternal HLA-G 1597ΔC null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women

scientific article published on 21 September 2012

The role of environmental tobacco smoke in genetic susceptibility to asthma

scientific article published in October 2004

The role of local CpG DNA methylation in mediating the 17q21 asthma-susceptibility GSDMB/ORMDL3 expression quantitative trait locus

scientific article published on 25 January 2018

The sex-specific genetic architecture of quantitative traits in humans

scientific article published on 22 January 2006

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

article

Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk

scientific article published on 03 January 2021

Ultra-fast local-haplotype variant calling using paired-end DNA-sequencing data reveals somatic mosaicism in tumor and normal blood samples

scientific article

Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry

scientific article

Variants in DPF3 and DSCAML1 are associated with sperm morphology

scientific article

Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample

scientific article published on 15 April 2005

Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations

scientific article published on 7 April 2005

Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility

scientific article published on 17 May 2006

Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.

scientific article published on 10 December 2005

Variation in the HLA-G Promoter Region Influences Miscarriage Rates ⬇️

scientific article published on April 29, 2003

Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy

scientific article published on 01 March 2006

Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma

scientific article

XM: association testing on the X-chromosome in case-control samples with related individuals

scientific article published on 02 May 2012

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