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List of works by Michael Detmar

A Human mAb Specific to Oncofetal Fibronectin Selectively Targets Chronic Skin Inflammation In Vivo

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

scientific article

A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression

scientific article

A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development ⬇️

scientific article published on November 23, 2010

A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research

scientific article

Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer

scientific article published on 25 June 2019

Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin ⬇️

scientific article published on 04 May 2013

Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth

scientific article published on April 2002

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

scientific article

Alternative transcription of a shorter, non-anti-angiogenic thrombospondin-2 variant in cancer-associated blood vessels.

scientific article published on 22 February 2018

An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo

scientific article published on December 2003

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

scientific journal article

An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells

scientific article

An important role of blood and lymphatic vessels in inflammation and allergy

scientific article published on 31 January 2013

An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth

scientific article published on 25 July 2019

An important role of lymphatic vessel activation in limiting acute inflammation

scientific article

An important role of podoplanin in hair follicle growth

scientific article published on 23 July 2019

An important role of the SDF-1/CXCR4 axis in chronic skin inflammation

scientific article

An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis

scientific article

An integrated expression atlas of miRNAs and their promoters in human and mouse.

scientific article

Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor ⬇️

scientific article published on July 6, 2012

Angiogenesis and lymphangiogenesis of skin cancers

scientific article published in October 2004

Angiogenesis, lymphangiogenesis, and melanoma metastasis

scientific article

Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation

article published in 2018

Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation

scientific article published on 15 August 2014

Blockade of VEGF Receptor-3 Aggravates Inflammatory Bowel Disease and Lymphatic Vessel Enlargement ⬇️

scientific article published on August 1, 2013

Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet

scientific article

Chapter 1. Inflammation, angiogenesis, and lymphangiogenesis

scientific article published on January 2008

Chronic high-fat diet impairs collecting lymphatic vessel function in mice

scientific article (publication date: 2014)

Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer

scientific article

Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro

scientific article

De novo design and optimization of Aurora A kinase inhibitors

DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium

scientific article published on 4 November 2015

DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C.

scientific article published on 19 May 2016

Development of the lymphatic vascular system: a mystery unravels

scientific article published in November 2004

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo

scientific article published on 20 March 2019

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo: authors' reply

scientific article published on 11 March 2020

Differential effects of photoaging vs intrinsic aging on the vascularization of human skin

scientific article published on November 2002

Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation.

scientific article published on 29 August 2017

Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance

scientific article

Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A)

scientific article published on 10 March 2016

Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In Vitro

scientific article published on 01 December 1990

Endocan Is Upregulated on Tumor Vessels in Invasive Bladder Cancer Where It Mediates VEGF-A–Induced Angiogenesis ⬇️

scientific article published on December 14, 2012

Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane).

scientific article

Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells

scientific article published on 12 September 2020

Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis

scientific article published on January 2004

Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta

scientific article

FANTOM5 CAGE profiles of human and mouse samples

scientific article published on 29 August 2017

Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles

scientific article published on 06 June 2014

G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer

scientific article published on 24 November 2015

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions

scientific article published on 4 March 2009

Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice

scientific article

Growth hormone promotes lymphangiogenesis

scientific article published on 26 June 2008

Hepatocyte growth factor promotes lymphatic vessel formation and function

scientific article

Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening

scientific article

Identification of the surface-accessible, lineage-specific vascular proteome by two-dimensional peptide mapping

article by Christoph Roesli et al published June 2008 in FASEB Journal

In Vivo Imaging of Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography ⬇️

scientific article published on January 1, 2013

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography

scientific article

Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice

scientific article published in January 2002

Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator ⬇️

scientific article published on October 16, 2012

Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia

scientific article published on 20 April 2004

Induction of lymphatic endothelial cell differentiation in embryoid bodies

scientific article published on 29 September 2005

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

article by Mihaela Skobe et al published February 2001 in Nature Medicine

Infantile hemangiomas are arrested in an early developmental vascular differentiation state

scientific article

Inflammation and Lymphatic Function

Inflammation-Induced Lymph Node Lymphangiogenesis Is Reversible ⬇️

scientific article published on December 23, 2011

Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor

scientific article published on 5 June 2008

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA receptors

scientific article published in Nature Communications

Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis

scientific article published on 24 June 2020

LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C

scientific article published on 10 February 2021

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

scientific article

Lymphangiogenesis and Cancer ⬇️

scientific article published on December 1, 2011

Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation

scientific article published on 05 June 2016

Lymphatic endothelium in health and disease

scientific article published on 22 July 2008

Lymphatic exosomes promote dendritic cell migration along guidance cues.

scientific article published on 12 April 2018

Lymphatic outflow of cerebrospinal fluid is reduced in glioma

scientific article published on 15 October 2019

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus

Lymphatic vessels: new targets for the treatment of inflammatory diseases

scientific article

Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function

scientific article

Lymphatics in nanophysiology

scientific article published on 10 February 2014

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

Mechanisms of lymphatic metastasis

scientific article published on 03 March 2014

Microneedles for the Noninvasive Structural and Functional Assessment of Dermal Lymphatic Vessels

scientific article published on 4 January 2016

Minimally invasive method for the point-of-care quantification of lymphatic vessel function

scholarly article by Anna K Polomska et al published 21 February 2019 in JCI insight

Molecular mechanisms and imaging of lymphatic metastasis ⬇️

scientific article published on March 13, 2013

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy

scientific article

Multifocal lymphangioendotheliomatosis with thrombocytopenia: a newly recognized clinicopathological entity

scientific article

Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity

scientific article

New insights into the biology and pathology of the cutaneous lymphatic system

scientific article published on June 2004

New insights into the molecular control of the lymphatic vascular system and its role in disease

scientific article published on October 2006

New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate

scientific article

Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease

scientific article published on 08 October 2009

Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling

scientific article published on 25 March 2022

Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation

scientific article

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice.

scientific article published on 10 November 2017

Pathways targeting tumor lymphangiogenesis

scientific article published on December 2006

Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3.

scientific article

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

scientific article

Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin

scientific article

Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo

scientific article published on 31 May 2011

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes

scientific article

Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema

scientific article published on 14 June 2016

Prox-1 promotes invasion of kaposiform hemangioendotheliomas

scientific article

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate

scientific article

Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis

scientific journal article

Prox1, master regulator of the lymphatic vasculature phenotype

scientific article

Quantitative imaging of lymphatic function with liposomal indocyanine green

scientific article

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein

scientific article

Reduction of lymphatic vessels in photodamaged human skin

scientific article

Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function

scientific article

Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice

scientific article

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

scientific article published on 06 April 2020

Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth

scientific article published on 12 May 2022

Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo

scientific article

Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea

scientific article

Steering target selectivity and potency by fragment-based de novo drug design

scientific article published on 26 August 2013

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

scientific article

Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice

scientific article published in April 2003

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis

scientific article published on 07 December 2009

Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy.

scientific article published on April 2002

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions

scientific article published in January 2017

TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays

scientific article

The Cutaneous Vascular System in Chronic Skin Inflammation ⬇️

scientific article published on December 1, 2011

The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma

scientific article

The formation of lymphatic vessels and its importance in the setting of malignancy

scientific article published on September 2002

The lymphatic system in health and disease

scientific article

The miR-290-295 cluster suppresses autophagic cell death of melanoma cells ⬇️

scientific article published on November 13, 2012

The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42

scientific article

The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature

scientific article

The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation

scientific article published on January 2014

The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis ⬇️

scientific article published on January 1, 2002

Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis

scientific article

Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice

scientific article

Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis

scientific article published on 18 January 2014

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

scientific article

Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis

scientific article published on 9 July 2008

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

scientific article published on 20 March 2003

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice

scientific article published on 11 August 2016

Tumor and lymph node lymphangiogenesis--impact on cancer metastasis

scientific article published on 22 June 2006

Tumor lymphangiogenesis and melanoma metastasis

scientific article published on August 2008

Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

scientific article

Tumor lymphangiogenesis and new drug development

scientific article published on 16 December 2015

Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes

scientific article

Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival

scientific article published on June 2003

Tumor progression: the effects of thrombospondin-1 and -2.

scientific article published on June 2004

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation

scientific article published on 03 February 2017

Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression

scientific article published in January 2004

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread

scientific article published on 08 August 2018

Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors

scientific article

Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis

scientific article

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

scientific article

VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes

scientific article

VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins

scientific article

VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis

scientific article published on 21 May 2013

VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

scientific article published on 10 October 2006

Vascular Endothelial Growth Factor-C (VEGF-C) and its Receptors KDR and flt-4 are Expressed in AIDS-Associated Kaposi’s Sarcoma

article

Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function

scientific article published on October 2006

Walking the Line: A Fibronectin Fiber-Guided Assay to Probe Early Steps of (Lymph)angiogenesis

scientific article

Watching lymphatic vessels grow by making them glow ⬇️

scientific article published on November 29, 2011

miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo

scientific article

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