List of works by Stephen S Whitehead

A 12-Month-Interval Dosing Study in Adults Indicates That a Single Dose of the National Institute of Allergy and Infectious Diseases Tetravalent Dengue Vaccine Induces a Robust Neutralizing Antibody Response

scientific article

A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers

scientific article

A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3' Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

scientific article (publication date: 2003)

A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus ⬇️

scientific article

A full-length infectious cDNA clone of Zika virus from the 2015 epidemic in Brazil as a genetic platform for studies of virus-host interactions and vaccine development

scientific article

A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus

scientific article

A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus

scientific article

A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial

scientific article published on 17 January 2013

A single dose of the DENV-1 candidate vaccine rDEN1Δ30 is strongly immunogenic and induces resistance to a second dose in a randomized trial

scientific article

A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.

scientific article published on July 2003

Arguments for live flavivirus vaccines

scientific article published in August 2004

Clinical and Virological Features of Dengue in Vietnamese Infants

scientific article (publication date: 13 April 2010)

Complexity of Neutralizing Antibodies against Multiple Dengue Virus Serotypes after Heterotypic Immunization and Secondary Infection Revealed by In-Depth Analysis of Cross-Reactive Antibodies

scientific article published on 13 May 2015

Corticosteroids for dengue - why don't they work?

scientific article

Decreased accumulation of subgenomic RNA in human cells infected with vaccine candidate DEN4Δ30 increases viral susceptibility to type I interferon

scholarly article by José Bustos-Arriaga et al published June 2018 in Vaccine

Dengue Human Infection Models to Advance Dengue Vaccine Development

scientific article published on 21 October 2015

Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys

scientific article published on 24 July 2017

Dengue human infection models to advance dengue vaccine development

scientific article published on 27 September 2015

Dengue research opportunities in the Americas

scientific article

Dengue vaccine candidates in development

scientific article published on January 2010

Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants

scientific article

Dengue virus type 3 vaccine candidates generated by introduction of deletions in the 3′ untranslated region (3′-UTR) or by exchange of the DENV-3 3′-UTR with that of DENV-4

scientific article (publication date: 6 February 2008)

Dengue viruses cluster antigenically but not as discrete serotypes

scientific article published on September 2015

Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine

scientific article

Development of TV003/TV005, a single dose, highly immunogenic live attenuated dengue vaccine; what makes this vaccine different from the Sanofi-Pasteur CYD™ vaccine?

scientific article

Development of a live attenuated dengue virus vaccine using reverse genetics

scientific article

Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses

scientific article published on 23 April 2015

Early Transcriptional Responses After Dengue Vaccination Mirror the Response to Natural Infection and Predict Neutralizing Antibody Titers

article

Effects of dengue immunity on Zika virus infection

scientific article published on 01 March 2019

Evaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeys

scientific article (publication date: 5 August 2008)

Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers

scientific article

Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques.

scientific article published on 24 April 2018

Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice

scientific article published on 8 April 2015

Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization

scientific article published on 01 October 2018

Genetic and phenotypic characterization of sylvatic dengue virus type 2 strains

scientific article published on August 2008

Genetic and phenotypic properties of vero cell-adapted Japanese encephalitis virus SA14-14-2 vaccine strain variants and a recombinant clone, which demonstrates attenuation and immunogenicity in mice

scientific article

Genetic basis of attenuation of dengue virus type 4 small plaque mutants with restricted replication in suckling mice and in SCID mice transplanted with human liver cells

scientific article published on August 2002

Genetically modified, live attenuated dengue virus type 3 vaccine candidates

scientific article

Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

scientific article (publication date: 8 May 2007)

Heterotypic dengue infection with live attenuated monotypic dengue virus vaccines: implications for vaccination of populations in areas where dengue is endemic

scientific article

Human CD4+ T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection, in magnitude, HLA restriction and antigen specificity

scientific article (publication date: 14 December 2016)

Human monoclonal antibodies derived from memory B cells following live attenuated dengue virus vaccination or natural infection exhibit similar characteristics

scientific article published on 22 March 2013

Immune response to dengue virus and prospects for a vaccine

scientific article published on January 2011

In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination

scientific article (publication date: May 2017)

Infection dynamics of sylvatic dengue virus in a natural primate host, the African Green Monkey

scientific article

Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity

scientific article published on September 2004

Investigation of dengue and Japanese encephalitis virus transmission in Hanam, Viet Nam.

scientific article

Japanese encephalitis virus vaccine candidates generated by chimerization with dengue virus type 4

scientific article

La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys

scientific article published on 11 February 2008

Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice.

scientific article

Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model

article

Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization

scientific article (publication date: 9 May 2008)

Mechanism and significance of cell type-dependent neutralization of flaviviruses

scientific article

Methods to discriminate primary from secondary dengue during acute symptomatic infection

Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells ⬇️

scientific article published on October 1, 2003

Next-generation dengue vaccines: novel strategies currently under development

scientific article

Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL.

scientific article published on 21 December 2017

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes

scientific article

Patterns of cellular immunity associated with experimental infection with rDEN2Δ30 (Tonga/74) supports its suitability as a human DENV challenge strain

scientific article (publication date: February 2017)

Phase 1 Trial of the Dengue Virus Type 4 Vaccine Candidate rDEN4 30-4995 in Healthy Adult Volunteers

scientific article (publication date: November 2009)

Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicity

scientific article

Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine

scientific article published on 6 September 2017

Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans

scientific article

Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys

scientific article

Replacement of conserved or variable sequences of the mosquito-borne dengue virus 3' UTR with homologous sequences from Modoc virus does not change infectivity for mosquitoes

scientific article published on 19 December 2012

Replacement of the 3' untranslated variable region of mosquito-borne dengue virus with that of tick-borne Langat virus does not alter vector specificity

scientific article

Report of an NIAID workshop on dengue animal models

scientific article

Response to Ruiz-Alejo et al.

scientific article published on 11 July 2013

Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice

scientific article published in Nature Communications

Soluble mediators produced by the crosstalk between microvascular endothelial cells and dengue-infected primary dermal fibroblasts inhibit dengue virus replication and increase leukocyte transmigration

scientific article published on July 2015

Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys ⬇️

scientific article published on October 1, 2003

Superior infectivity for mosquito vectors contributes to competitive displacement among strains of dengue virus

scientific article

Tahyna virus genetics, infectivity, and immunogenicity in mice and monkeys

scientific article published on 24 March 2011

Targeted mutagenesis as a rational approach to dengue virus vaccine development

scientific article

Temperature-dependent production of pseudoinfectious dengue reporter virus particles by complementation

scientific article

The dengue human challenge model: has the time come to accept this challenge?

scientific article published on 5 December 2012

The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys

scientific article published in 2011

The human CD8+ T cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes

scientific article

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity

scientific article published on September 2010

The live attenuated chimeric vaccine rWN/DEN4Δ30 is well-tolerated and immunogenic in healthy flavivirus-naïve adult volunteers

scientific article published on 19 August 2013

The live attenuated dengue serotype 1 vaccine rDEN1Delta30 is safe and highly immunogenic in healthy adult volunteers.

scientific article published on 24 July 2006

The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model

scientific article

The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein

scientific article

Vaccination of volunteers with low-dose, live-attenuated, dengue viruses leads to serotype-specific immunologic and virologic profiles

scientific article published on 02 June 2013

Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2

scientific article

Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1

scientific article (publication date: 28 February 2007)

Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Risks of Incomplete Immunity to Dengue Virus Revealed by Vaccination

scientific article published on 17 July 2017

Zika Vaccines: Role for Controlled Human Infection

scientific article published in December 2017

rDEN2/4Delta30(ME), a live attenuated chimeric dengue serotype 2 vaccine is safe and highly immunogenic in healthy dengue-naïve adults.

scientific article published on 5 November 2006

rDEN4delta30, a live attenuated dengue virus type 4 vaccine candidate, is safe, immunogenic, and highly infectious in healthy adult volunteers

scientific article published on 27 January 2005

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