List of works - Meredith Jackrel

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

scientific article

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

scientific article published on 5 April 2017

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

scientific article published on 5 October 2015

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

scientific article published on 05 June 2019

Engineering enhanced protein disaggregases for neurodegenerative disease

scientific article

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

scientific article published on 15 March 2017

Functional analysis of proposed substrate-binding residues of Hsp104

scientific article published on 10 March 2020

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

scientific article published on 05 April 2019

Isolating potentiated Hsp104 variants using yeast proteinopathy models

scientific article

Mechanistic Insights into Hsp104 Potentiation

scientific article published on 8 January 2016

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

scientific article published on 01 August 2019

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

scientific article published on 01 April 2018

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

scientific article published on November 2012

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

scientific article published on January 2014

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

scientific article

Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain

scientific article published on 01 August 2018

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

scientific article published on 28 February 2017

Quality Control in the ER: Misfolded Prohormones Get a Checkup

scientific article published on 01 August 2019

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

scientific article published on 15 June 2017

Redesign of a protein - peptide interaction: Characterization and applications

scientific article

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

scientific article published on 2 April 2014

Shock and awe: unleashing the heat shock response to treat Huntington disease.

scientific article published on 25 July 2011

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

scientific article

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

scientific article published on 27 December 2018

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

scientific article

Therapeutic genetic variation revealed in diverse Hsp104 homologs

scientific article published on 15 December 2020

List of works by Meredith Jackrel

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

Engineering enhanced protein disaggregases for neurodegenerative disease

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

Functional analysis of proposed substrate-binding residues of Hsp104

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

Isolating potentiated Hsp104 variants using yeast proteinopathy models

Mechanistic Insights into Hsp104 Potentiation

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

Quality Control in the ER: Misfolded Prohormones Get a Checkup

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Redesign of a protein - peptide interaction: Characterization and applications

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

Shock and awe: unleashing the heat shock response to treat Huntington disease.

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

Therapeutic genetic variation revealed in diverse Hsp104 homologs