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List of works by Christa Flück

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NADPH P450 oxidoreductase: structure, function, and pathology of diseases

scientific article
Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation

scientific article
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

scientific article
Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in theZinc Transporter ZnT-2 (SLC30A2)Gene in the Mother Highlighting the Importance of Zn2+for Normal Growth and Development

scientific article published on September 29, 2013
High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes

scientific article published on September 3, 2010
Caring for individuals with a difference of sex development (DSD): a Consensus Statement

article
Reduction in hepatic drug metabolizing CYP3A4 activities caused by P450 oxidoreductase mutations identified in patients with disordered steroid metabolism

scientific article
Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents

scientific article published on 29 April 2009
Anti-Müllerian hormone levels in girls and adolescents with Turner syndrome are related to karyotype, pubertal development and growth hormone treatment.

scientific article
SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes

scientific article published on 26 April 2012
Restoration of mutant cytochrome P450 reductase activity by external flavin

scientific article
Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain

scientific article
Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia

scientific article
Testicular differentiation factor SF-1 is required for human spleen development

scientific article published on 08 April 2014
Characterization of a novel CYP19A1 (aromatase) R192H mutation causing virilization of a 46,XX newborn, undervirilization of the 46,XY brother, but no virilization of the mother during pregnancies

scientific article published on 4 April 2014
Congenital Hypogonadotropic Hypogonadism and Constitutional Delay of Growth and Puberty Have Distinct Genetic Architectures

scientific article published in February 2018
Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation

scientific article published on 31 January 2013
Nomenclature for alleles of the cytochrome P450 oxidoreductase gene

scientific article published on July 2009
Impact of differential P450c17 phosphorylation by cAMP stimulation and by starvation conditions on enzyme activities and androgen production in NCI-H295R cells

scientific article published on 9 June 2010
Butyrate increases intracellular calcium levels and enhances growth hormone release from rat anterior pituitary cells via the G-protein-coupled receptors GPR41 and 43

scientific article
Novel Insight into Etiology, Diagnosis and Management of Primary Adrenal Insufficiency

scientific article published on January 1, 2014
Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase

scientific article published on 21 August 2010
Steroidogenesis of the testis -- new genes and pathways

scientific article published on 29 April 2014
Modeling of human P450 oxidoreductase structure by in silico mutagenesis and MD simulation

scientific article published on 8 September 2009
Clinical and Biochemical Consequences of P450 Oxidoreductase Deficiency

scientific article published on December 16, 2010
Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome.

scientific article published on 25 July 2016
Impact of estrogen replacement throughout childhood on growth, pituitary-gonadal axis and bone in a 46,XX patient with CYP19A1 deficiency

scientific article published on 6 September 2012
Adrenal insufficiency after glucocorticoid withdrawal in children with rheumatic diseases

scientific article
P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms

scientific article
Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis

scientific article published on 13 May 2015
Deletion of P399_E401 in NADPH cytochrome P450 oxidoreductase results in partial mixed oxidase deficiency

scientific article
Human NR5A1/SF-1 mutations show decreased activity on BDNF (brain-derived neurotrophic factor), an important regulator of energy balance: testing impact of novel SF-1 mutations beyond steroidogenesis

scientific article
Broad phenotypes in heterozygous NR5A1 46,XY patients with a disorder of sex development: an oligogenic origin?

scientific article published on 11 June 2018
Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells

scientific article
MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction

scientific article
Differential regulation of human 3β-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model.

scientific article
Vitamin D-Dependent Rickets Type 1 Caused by Mutations in CYP27B1 Affecting Protein Interactions With Adrenodoxin

scientific article published on 11 July 2016
Evaluating CHARGE syndrome in congenital hypogonadotropic hypogonadism patients harboring CHD7 variants

scientific article published on 16 November 2017
Resveratrol inhibits androgen production of human adrenocortical H295R cells by lowering CYP17 and CYP21 expression and activities.

scientific article
Growth Hormone (GH)-Releasing Hormone Increases the Expression of the Dominant-Negative GH Isoform in Cases of Isolated GH Deficiency due to GH Splice-Site Mutations

scientific article published on March 29, 2010
Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature.

scientific article published on 19 August 2015
Autologous transplantation of cryopreserved ovarian tissue to induce puberty-the endocrinologists' view.

scientific article published on 15 September 2016
Metabolic control of type 1 diabetic patients followed at the University Children's Hospital in Berne: have we reached the goal?

scientific article published on 16 July 2010
Growth hormone (GH) deficiency type II: a novel GH-1 gene mutation (GH-R178H) affecting secretion and action

scientific article published in December 2009
Impact on CYP19A1 activity by mutations in NADPH cytochrome P450 oxidoreductase

scientific article
Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites

scientific article published in PLoS ONE
Alteration of ZnT5-Mediated Zinc Import into the Early Secretory Pathway Affects the Secretion of Growth Hormone from Rat Pituitary Cells

scientific article published on August 30, 2014
Rescue of Isolated GH Deficiency Type II (IGHD II) via Pharmacologic Modulation of GH-1 Splicing

scientific article published on 2 June 2016
Regulation of human (adrenal) androgen biosynthesis-New insights from novel throughput technology studies.

scientific article
Regulation of androgen biosynthesis - A short review and preliminary results from the hyperandrogenic starvation NCI-H295R cell model.

scientific article published on 24 December 2014

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