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List of works by Luis Menéndez-Arias

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries

scientific article published on 8 September 2017

5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase

article

A BASIC microcomputer program for prediction of B and T cell epitopes in proteins ⬇️

scientific article published on April 1, 1990

A Mg2+-induced conformational switch rendering a competent DNA polymerase catalytic complex

scientific article published on 01 May 2008

A structural comparison of type c lysozymes based on their hydropathic profiles

scientific article published on 01 July 1987

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis ⬇️

scientific article published on February 26, 2013

Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway

scientific article published on 22 December 2017

Amino acid sequence around the cysteine residues of pigeon egg-white lysozyme: comparative study with other type c lysozymes

article by Luis Menéndez-Arias et al published 1 January 1985 in Comparative Biochemistry and Physiology Part B: Comparative Biochemistry

Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation.

scientific article published on 17 October 2014

Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection.

scientific article published on 15 December 2013

Article Commentary: A Structural Frame for Understanding the Role of Thymidine Analogue Resistance Mutations in Resistance to Zidovudine and Other Nucleoside Analogues ⬇️

scientific article published on 01 January 2011

Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate.

scientific article published in September 1997

Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes

scientific article

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

scientific article published on 13 August 2012

Comparative study on the secondary structure of lysozymes from different sources.

scientific article published in January 1984

Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type 1 reverse transcriptase.

scientific article published in June 2000

Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis.

scientific article published on July 2003

Defective Strand-Displacement DNA Synthesis Due to Accumulation of Thymidine Analogue Resistance Mutations in HIV-2 Reverse Transcriptase

scientific article published on 11 March 2020

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase

scientific article published on 06 July 2019

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors

scientific article published on 24 January 2019

Editorial overview: antivirals and resistance: advances and challenges ahead.

scientific article published on 22 August 2014

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.

scientific article published on 20 May 2009

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.

scientific article published on 6 February 2015

Engineering protein thermal stability. Sequence statistics point to residue substitutions in alpha-helices.

scientific article published in March 1989

Epitope mapping of the major allergen from yellow mustard seeds, Sin a I

scientific article published on 01 February 1990

Evidence and controversies on the role of XMRV in prostate cancer and chronic fatigue syndrome

scientific article

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

scientific article published on December 2003

Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strains.

scientific article published on 15 May 2001

HIV protease cleaves poly(A)-binding protein.

scientific article published on June 2006

HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2

scientific article

HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions.

scientific article published on 03 July 2007

HIV-1 reverse transcriptase connection subdomain mutations involved in resistance to approved non-nucleoside inhibitors.

scientific article published on 28 August 2011

HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations

article

HIV-resistance to viral entry inhibitors.

scientific article published on January 2004

Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.

scientific article

Insertions and deletions in HIV-1 reverse transcriptase: consequences for drug resistance and viral fitness.

scientific article

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

scientific article

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase.

scientific article published on 16 March 2012

Investigation of the dNTP-binding site of HIV-1 reverse transcriptase using photoreactive analogs of dNTP.

scientific article published in September 2001

Major groove binding track residues of the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase enhance cDNA synthesis at high temperatures

scientific article published on 12 December 2013

Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.

scientific article published on 12 February 2008

Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis.

scientific article

Molecular basis of human immunodeficiency virus drug resistance: an update.

scientific article published on 16 July 2009

Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments.

scientific article published on 08 February 2013

Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients

scientific article published on 22 March 2014

Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN

scientific article published on 25 March 2004

Moloney murine leukemia virus protease: bacterial expression and characterization of the purified enzyme.

scientific article published in October 1993

Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors.

scientific article published in October 2002

Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.

scientific article published on 04 December 2009

Mutational Patterns Associated with the 69 Insertion Complex in Multi-drug-resistant HIV-1 Reverse Transcriptase that Confer Increased Excision Activity and High-level Resistance to Zidovudine

article

Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.

scientific article published in July 1999

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.

scientific article published on November 2007

Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance.

scientific article published on 09 May 2014

RNA virus fitness.

scientific article published in July 1997

Relationship between hydropathic variability and functional properties of alpha-lactalbumins and type c lysozymes

scientific article published on 01 May 1987

Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region

scientific article published on 21 February 2007

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

scientific article published on August 2004

Retroviral reverse transcription

scientific article published on 04 March 2008

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

scientific article

SAMHD1 is active in cycling cells permissive to HIV-1 infection

scientific article published on 27 March 2017

Sequence analysis of HIV-1 vif gene in Spanish isolates.

scientific article published in February 1995

Sequence analysis of the polymerase domain of HIV-1 reverse transcriptase in naive and zidovudine-treated individuals reveals a higher polymorphism in alpha-helices as compared with beta-strands.

scientific article published in January 1999

Special issue: retroviral enzymes.

scientific article published on 07 May 2010

Structure of the pigeon lysozyme and its relationship with other type c lysozymes

scientific article published on 01 January 1987

Studies on the effects of truncating alpha-helix E' of p66 human immunodeficiency virus type 1 reverse transcriptase on template-primer binding and fidelity of DNA synthesis.

scientific article

Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.

scientific article published on 19 April 2005

Targeting HIV: antiretroviral therapy and development of drug resistance.

scientific article

Temperature effects on the fidelity of a thermostable HIV-1 reverse transcriptase

scientific article published on 26 November 2013

Template-primer binding affinity and RNase H cleavage specificity contribute to the strand transfer efficiency of HIV-1 reverse transcriptase

scientific article published in Journal of Biological Chemistry

The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases ⬇️

scientific article published on December 1, 2003

Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.

scientific article published in June 2011

Thymidine analogue excision and discrimination modulated by mutational complexes including single amino acid deletions of Asp-67 or Thr-69 in HIV-1 reverse transcriptase.

scientific article published on 19 April 2011

Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.

scientific article published on 29 September 2009

Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.

scientific article published on 12 January 2018

Tryptophan scanning mutagenesis of aromatic residues within the polymerase domain of HIV-1 reverse transcriptase: critical role of Phe-130 for p51 function and second-site revertant restoring viral replication capacity.

scientific article published on July 2004

Viral polymerases

scientific article published on 7 February 2017

Viral reverse transcriptases.

scientific article published on 30 December 2016

Virus population dynamics, fitness variations and the control of viral disease: an update

scientific article

β-Turns as structural motifs for the proteolytic processing of seed proteins

scientific article published on 01 April 1990

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