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List of works by Yoshikuni Mizuno

14-3-3eta is a novel regulator of parkin ubiquitin ligase

scientific article

A 54-year-old man with familial parkinsonism, gaze palsy, and dementia

scientific article published in December 2005

A 59-year-old woman with personality change and abnormal behavior followed by amyotrophy and dementia

scientific article

A 60-year-old man with intention tremor as an initial symptom followed by cerebellar ataxia, peripheral neuropathy and dementia

scientific article

A 65-year-old man with rigid-bradykinetic parkinsonism, vertical gaze palsy, difficulty of eye-lid opening, and marked pseudo-bulbar palsy

scientific article published in January 2005

A 65-year-old woman with progressive loss of vision and visual field defects

scientific article published in January 2003

A 67-year-old man with rt. hand resting tremor and rigidity after lt. putaminal hemorrhage

scientific article published in March 2005

A 68-year-old woman with dementia and parkinsonism

scientific article

A 76-year-old woman with personality change, dementia and parkinsonism

scientific article published in November 2005

A Randomized Double-Blind Placebo-Controlled Phase III Trial of Selegiline Monotherapy for Early Parkinson Disease

scientific article published on 28 August 2017

A collaborative study on the malignant syndrome in Parkinson's disease and related disorders ⬇️

scientific article published on April 1, 2003

A combinatorial code for the interaction of alpha-synuclein with membranes

scientific article published on 14 July 2005

A long-term study of istradefylline safety and efficacy in patients with Parkinson disease

scientific article published in March 2015

A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology

scientific article published in January 2003

A patient with Hashimoto's encephalopathy showing subacute global cognitive dysfunction

scientific article published on June 1, 2003

A possible role for humoral immunity in the pathogenesis of Parkinson's disease

scientific article

A reassessment of risks and benefits of dopamine agonists in Parkinson's disease

scientific article

Accumulation of α-Synuclein Triggered by Presynaptic Dysfunction ⬇️

scientific article published on November 28, 2012

Adeno-associated viral vector-mediated gene transduction in mesencephalic slice culture ⬇️

scientific article published on July 23, 2011

Adeno-associated virus-mediated antiapoptotic gene delivery: in vivo gene therapy for neurological disorders

scientific article

Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease ⬇️

scientific article published on March 11, 2013

Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease

scientific article published on 18 September 2007

Amyotrophic lateral sclerosis presented with alexia of kanji and word meaning aphasia

scientific article published in October 2002

An 80-year-old woman with progressive stroke, who had rheumatoid arthritis and antiphospholipid syndrome

scientific article (publication date: February 2006)

An 81-year-old man with personality change, dementia, and gait disturbance with diffuse leukoaraiosis of the cerebral white matter

scientific article published in January 2006

An autopsy case of Schilder's variant of multiple sclerosis (Schilder's disease).

scientific article published on 21 April 2006

An extremely unusual presentation of varicella zoster viral infection of cranial nerves mimicking Garcin syndrome

scientific article

An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys

scientific article

Analysis of eighteen deletion breakpoints in the parkin gene

scientific article

Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy

scientific article published in June 2002

Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice

scientific article published in September 2004

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

scientific article

Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study

scientific article published on June 2003

Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth

scientific journal article

Blepharospasm associated with multiple system atrophy: a case report and review of the literature

scientific article published on March 2004

Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

scientific article published in February 2004

Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication.

scholarly article by Asako Yoritaka et al published 1997 in Journal of Neural Transmission

Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion

scientific article published on 27 April 2006

Clinical efficacy of istradefylline (KW-6002) in Parkinson's disease: a randomized, controlled study

scientific article published on July 2010

Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease.

scientific article

Clustering of risk factors increases the incidence of echolucent carotid plaque in stroke patients

scientific article published on 11 August 2006

Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells

scientific article

Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease.

scientific article

Contrasting genotypes of the tau gene in two phenotypically distinct patients with P301L mutation of frontotemporal dementia and parkinsonism linked to chromosome 17.

scientific article published in June 2002

Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease

scientific article published on 23 May 2007

Cortical myoclonus due to hypocalcemia 12 years after thyroidectomy

scientific article published in June 2006

Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography

scientific article published in November 2006

Determination of medullasin levels for the diagnosis of multiple sclerosis

scientific article published in March 2002

Diagnostic accuracy of 123I-meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: a multicenter study

scientific article

Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force

scientific article published on December 2007

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

scientific article published on 13 February 2011

Discovery of the parkin gene; the gene for young onset autosomal recessive parkinsonism (AR)

scientific article published in November 2007

Dominant-negative effect of mutant valosin-containing protein in aggresome formation

scientific article published on 22 December 2005

Dopamine Deficiency May Lead to Capgras Syndrome in Parkinson’s Disease With Dementia ⬇️

scientific article published on January 1, 2010

Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation

scientific article

Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier

scientific article

Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

scientific article

Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model

scientific article published on 25 January 2006

Dual role of Fcgamma receptor in transient focal cerebral ischemia in mice

scientific article published on 26 February 2004

EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population

scientific article

Early addition of selegiline to L-Dopa treatment is beneficial for patients with Parkinson disease

scientific article published in January 2010

Ectopic expression of α-synuclein affects the migration of neural stem cells in mouse subventricular zone

scientific article

Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain

scientific article published on 15 September 2005

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

scientific article published on 28 May 2002

Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease

scientific article

Effects of donepezil dose escalation in Parkinson's patients with dementia receiving long-term donepezil treatment: an exploratory study

scientific article published on 24 March 2014

Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.

scholarly article by M Yamamoto et al published 1997 in Journal of Neural Transmission

Efficacy, safety, and tolerability of overnight switching from immediate- to once daily extended-release pramipexole in early Parkinson's disease

scientific article published on October 2010

Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders

scientific article published in March 2003

Excessive daytime sleepiness and low CSF orexin-A/hypocretin-I levels in a patient with probable progressive supranuclear palsy

scientific article published in December 2003

Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains

scientific article

Expanding the clinical phenotype of SNCA duplication carriers

scientific article

Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease

scientific article published in May 2006

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

scientific article published on 17 November 2004

Expression patterns of tau mRNA isoforms correlate with susceptible lesions in progressive supranuclear palsy and corticobasal degeneration

scientific article published in August 2002

Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration

scientific article published on October 2003

Familial amyotrophic lateral sclerosis with rapid progression

scientific article published in November 2005

Familial hemifacial spasm: report of cases and review of literature ⬇️

scientific article published on January 15, 2002

Four-repeat tau-positive Pick body-like inclusions are distinct from classic Pick bodies

scientific article

Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction

scientific article

Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease

scientific article published on 14 July 2005

Genetic association between susceptibility to Parkinson's disease and α1-antichymotrypsin polymorphism ⬇️

scientific article published on June 6, 1997

Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain

scientific article published on 19 June 2006

Genotype-phenotype correlation: familial Parkinson disease

scientific article

Geographic and ethnic differences in frequencies of two polymorphisms (D/N394 and L/I272) of the parkin gene in sporadic Parkinson's disease.

scientific article

Glial localization of four-repeat tau in atypical progressive supranuclear palsy

scientific article

Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

scientific article published in November 2002

Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease

scientific article published on January 2003

Histochemical detection of apoptosis in Parkinson's disease.

scientific article published on 01 May 1996

Hoarseness due to bilateral vocal cord paralysis as an initial manifestation of familial amyotrophic lateral sclerosis

scientific article published in June 2005

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway

scientific article published on 8 June 2015

Identification of neurite outgrowth active sites on the laminin alpha4 chain G domain

scientific article

In pursuit of the causes for Parkinson disease

scientific article

Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in rat brain after focal ischemia/reperfusion

scientific article published in March 2002

Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro

scientific article published on 17 January 2006

Isolated deep cerebral venous thrombosis: an important cause for isolated mental impairment

scientific article published on 18 August 2004

Isolated reversible splenial lesion in adult meningitis: a case report and review of the literature

scientific article

LRRK2 P755L variant in sporadic Parkinson's disease

scientific article published on 16 October 2008

Late onset hemiparkinsonism-hemiatrophy syndrome: a case report

scientific article published in May 2005

Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population

scientific article published in February 2007

Leucine-rich repeat kinase 2 associates with lipid rafts

scientific journal article

Lewy body pathology in a patient with a homozygous parkin deletion

scientific article

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: implications of autophagy promotion

scientific article published on 10 January 2012

Long-term treatment of Parkinson's disease patients with selegiline hydrochloride (FPF 1100): outcome of 5-year treatment

scientific article published in December 2002

Long-term treatment of Parkinson's disease with levodopa and other adjunctive drugs

scientific article published on 16 January 2017

Loss of DARPP-32 and calbindin in multiple system atrophy ⬇️

scientific article published on May 29, 2013

Malignant syndrome in Parkinson's disease: concept and review of the literature ⬇️

scientific article published on April 1, 2003

Mechanism and treatment of dropped head syndrome associated with parkinsonism

scientific article published on 24 June 2008

Milestones in PD genetics

scientific article published on May 2011

Minimal clinically important difference in Parkinson's disease as assessed in pivotal trials of pramipexole extended release

scientific article published on April 2014

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

scientific article published on 6 October 2012

Mitochondrial genome variation in eastern Asia and the peopling of Japan

scientific article

Molecular genetic analysis of a novelParkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in theParkin gene in affected individuals

article

Mortality associated with selegiline in Parkinson's disease. What do the available data mean?

scientific article published on May 1997

Multiplex families with multiple system atrophy

scientific article

Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism

scientific article

Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease

scientific article published on June 2008

Nationwide multicenter prospective study on the long-term effects of bromocriptine for Parkinson's disease. Final report of a ten-year follow-up.

scholarly article by N Ogawa et al published 1997 in European Neurology

Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector

scientific article published on 8 April 2004

Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice

scientific article published in March 2006

Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice

scientific article published on 21 September 2004

Novel PINK1 mutations in early-onset parkinsonism

scientific article

Nuclear localization of the 20S proteasome subunit in Parkinson's disease

scientific article published in October 2006

Official Japanese Version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale: validation against the original English version

scientific article

On-line Computer Diagnosis of Arrhythmias on ECG Using by Small Scale Digital Computer System ⬇️

scientific article

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

scientific article published on October 2004

Parkin and Parkinson disease

scientific article published in May 2012

Parkin and endoplasmic reticulum stress

scientific article

Parkin attenuates manganese-induced dopaminergic cell death

scientific article published on June 2004

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

scientific article (publication date: March 2003)

Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain

scientific article (publication date: 24 October 2003)

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

scientific article

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

scientific article published on May 2002

Parkin stabilizes PINK1 through direct interaction

scientific article published on 7 April 2009

Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease

scientific article published in August 2011

Pathogenetic mechanisms of parkin in Parkinson's disease

scientific article published in August 2004

Pathological and biochemical studies on a case of Pick disease with severe white matter atrophy

scientific article

Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson's disease

scientific article

Point Mutations (Thr240Arg and Ala311Stop) in theParkinGene

article

Positive immunoreactivity for vesicular monoamine transporter 2 in Lewy bodies and Lewy neurites in substantia nigra

scientific article published on 28 December 2005

Possibility for neurogenesis in substantia nigra of parkinsonian brain

scientific article published in July 2005

Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial

scientific article published on 31 May 2013

Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2.

scientific article published in October 2005

Prevention and treatment of malignant syndrome in Parkinson's disease: a consensus statement of the malignant syndrome research group ⬇️

scientific article published on April 1, 2003

Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions

scientific article published in January 2005

Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

scientific article

Progress in diagnosis and therapy for Parkinson's disease

scientific article published in August 2002

Progress in the pathogenesis and genetics of Parkinson's disease

scientific article published on June 2008

Randomized, double-blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson's disease

scientific article published on November 2010

Randomized, double‐blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease ⬇️

scientific article published on October 1, 2003

Rapid screening of ATP13A2 variant with high-resolution melting analysis

scientific article published in October 2010

Rationale for delayed-start study of pramipexole in Parkinson's disease: the PROUD study

scientific article published in August 2010

Recessive Parkinson's disease

scientific article

Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels

scientific article published in November 2006

Relationship between Parkinson disease with dementia and dementia with Lewy bodies

scientific article published in August 2005

Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies

scientific article published on 3 December 2007

Sensory neuropathy in autosomal recessive juvenile parkinsonism (PARK2).

scientific article published in June 2003

Serum creatine kinase is elevated in patients with Parkinson's disease: a case controlled study ⬇️

scientific article published on April 1, 2003

Siah-1 facilitates ubiquitination and degradation of synphilin-1

scientific article

Statistical parametric mapping of immunopositive cell density

scientific article published on 17 July 2006

The fate of neural progenitor cells expressing astrocytic and radial glial markers in the postnatal rat dentate gyrus

scientific article published in October 2005

The frequency of cardiac valvular regurgitation in Parkinson's disease

scientific article published in May 2008

The isolation of neural stem cells from the olfactory bulb of Parkinson's disease model

scientific article published on 12 January 2007

The neuromythology of Parkinson's Disease

scientific article published on July 2004

The unrelated communication interlude (UCI)--an automatic behavior phenomenon in Parkinson's disease

scientific article published on 7 June 2012

Twenty years since the discovery of the parkin gene

scientific article

Ubiquitin, proteasome and parkin

scientific article

Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease

scientific article published on 14 June 2006

Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease

scientific article

[Mitochondrial dysfunction in Parkinson's disease].

scientific article

[Progress in the basic and clinical aspects of Parkinson's disease].

scientific article

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain

scientific article published on 29 December 2006

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