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List of works by Rudy J Castellani

5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology

scientific article published on 18 July 2019

A critical review of chronic traumatic encephalopathy

scientific article published on 13 July 2015

A novel human disease with abnormal prion protein sensitive to protease

scientific article

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

scientific article

ADVANCED GLYCATION AND LIPID MODIFICATION OF ROSENTHAL FIBERS IN ALEXANDERʼS DISEASE

Accumulation of intraneuronal amyloid-β is common in normal brain.

scientific article

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

scientific article published on 27 March 2012

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

scientific article

Alzheimer Disease Pathology in Middle Age Reveals a Spatial-Temporal Disconnect Between Amyloid-β and Phosphorylated Tau

scientific article

Alzheimer disease

scientific article published on 01 September 2010

Alzheimer disease pathology as a host response

scientific article published on June 2008

Alzheimer’s disease therapy: a moving target

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

scientific article

Anesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology and functional outcome

scientific article published on 08 July 2019

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

scientific article

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

scientific article published on 18 October 2013

Antioxidant approaches for the treatment of Alzheimer's disease

scientific article published on July 2010

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

scientific article

Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease

scientific article

Are Alzheimer's Disease and Aging Evolutionary?

scholarly article by George Perry et al published 6 May 2013 in Journal of Alzheimer's Disease

Bilateral internal carotid absence: a case report of a rare congenital anomaly.

scientific article published on 20 June 2007

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

scientific article

Can Neck Contusions in Unexplained Pediatric Deaths be Explained by Cardiopulmonary Resuscitation?

scientific article published on 12 October 2018

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis

scientific article

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

scientific article

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

scientific article published on 09 December 2008

Cellular Respiration and Tumor Suppressor Genes

article

Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis

scientific article published on May 2004

Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury

scientific article published on 12 November 2020

Cerebrotendinous xanthomatosis: a critical update

article published in 2008

Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress

scientific article

Cerebrovascular and mitochondrial abnormalities in Alzheimer's disease: a brief overview

scientific article

Chapter 19. Targeting Oxidative Mechanisms in Alzheimer Disease

Chitin-like polysaccharides in Alzheimer's disease brains

scientific article

Chronic Traumatic Encephalopathy Pathology After Shotgun Injury to the Brain

scientific article published on 15 January 2019

Chronic effects of mild neurotrauma: putting the cart before the horse?

scientific article

Co-administration of TiO2-nanowired dl-3-n-butylphthalide (dl-NBP) and mesenchymal stem cells enhanced neuroprotection in Parkinson's disease exacerbated by concussive head injury

scientific article published on 09 November 2020

Cocaine-induced intracerebral hemorrhage in a patient with cerebral amyloid angiopathy.

scientific article published in September 2010

Commentary on: Schuman MJ, Hutchins KD. Severe retinal hemorrhages with retinoschisis in infants are not pathognomonic for abusive head trauma. J Forensic Sci 2017;62(3):807-11.

scientific article published in November 2017

Concussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO2-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cells

scientific article published on 02 November 2020

Consensus statement on concussion in sport-the 5th international conference on concussion in sport held in Berlin, October 2016.

scientific article published on 26 April 2017

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

scientific article published in July 2004

Current approaches in the treatment of Alzheimer's disease

scientific article published on 17 March 2008

DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease

scientific article published on 14 June 2011

Dementia Pugilistica Revisited

scientific article published on 8 October 2017

Diabetes exacerbates brain pathology following a focal blast brain injury: New role of a multimodal drug cerebrolysin and nanomedicine

scientific article published on 09 November 2020

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

article

Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration?

scientific article published on 19 April 2012

Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

scientific article

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

scientific article published on 23 July 2009

Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease

scientific article

Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain.

scientific article published on 20 October 2008

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

scientific article published on April 2009

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

scientific article published on 23 April 2008

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

scientific article published on 11 September 2008

Familial primary progressive aphasia

scientific article

Frontiers in Alzheimer's disease therapeutics

scientific article

Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease

scientific article published in October 1996

Hibernation, a Model of Neuroprotection

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

scientific article published in February 2002

Hydroxynonenal generated crosslinking fluorophores accumulate in Alzheimer's disease

scholarly article by Justin C. Shenk et al published July 2009 in Alzheimer's and Dementia

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

scientific article published on 12 November 2011

In Memoriam: Mark A. Smith, PhD

In Memoriam: Mark A. Smith, PhD: Neuroscientist and Visionary

Increased expression of p130 in Alzheimer disease

scientific article published on 28 September 2006

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

scientific article

Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease

scientific article published in September 1995

Infographic: Consensus statement on concussion in sport

scientific article published on 12 September 2017

Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage

scientific journal article

Involvement of oxidative stress in Alzheimer disease

scientific article

Iron: A Pathological Mediator of Alzheimer Disease? ⬇️

scientific article published on January 31, 2009

Iron: the Redox-active center of oxidative stress in Alzheimer disease

scientific article published on 17 May 2007

Is Alzheimers Disease a Myth? When is Disease a Disease?

Is exercise-in-a-bottle likely to proffer new insights into Alzheimer's disease?

scientific article published on October 2013

Lipid peroxidation markers are associated with granulovacuolar degeneration but not lipofuscin formation

Malignant glioma progression and nitric oxide

scientific article published on 12 September 2006

Mark A. Smith

Mark A. Smith, 1965-2010: consummate student of pathogenesis

scientific article published on 10 October 2011

Mark A. Smith, PhD: Renegade Scientist and Visionary

Mark A. Smith: neurocytochemistry innovator

scientific article published on 23 January 2012

Mark A. Smith: the scientist, the man.

scientific article published in October 2011

Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study

scientific article published in September 2002

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation ⬇️

scientific article published on May 1, 2003

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

scientific article published on 09 November 2020

Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

scientific article published on 7 December 2012

Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches

scientific article published on 26 March 2009

Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

article

Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis

Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies

scientific article published in November 2002

Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?

scientific article published on May 2007

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream

scientific article published on 3 May 2006

Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury

scientific article published on 01 January 2019

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

scientific article

Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140 on microvascular permeability, blood flow disturbances, edema formation, cell injury and nitric oxide synthase upregulation following trauma to the spinal cord

scientific article published on 09 July 2019

No Evidence of Increased Chronic Traumatic Encephalopathy Pathology or Neurodegenerative Proteinopathy in Former Military Service Members: A Preliminary Study

scientific article published on 01 January 2019

Nonestrogen-based hormonal therapies for Alzheimer’s disease

O2-04-07 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1 associated regulator of cyclin B, in Alzheimer disease

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

article

Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

scientific article

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative damage in the olfactory system in Alzheimer's disease

scientific article

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis ⬇️

scientific article published on October 30, 2010

Oxidative damage to RNA in aging and neurodegenerative disorders

scientific article published on 06 June 2012

Oxidative damage to nucleic acids in human prion disease

scientific article published in April 2002

Oxidative stress and neurodegeneration

scientific article

Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease

scientific article

Pathogenesis and disease-modifying therapy in Alzheimer's disease: the flat line of progress

scientific article published on 16 October 2012

Pathological phenotype in familial neurodegenerative disease: implications for families and therapeutic constructs

Pathology's new role: defining disease process and protective responses.

scientific article published in January 2008

Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine

scientific article published on 13 May 2020

Phosphorylated tau: toxic, protective, or none of the above

scientific article published on August 2008

Plaques and tangles: Birthmarks of the aging soul

scholarly article by George Perry & Rudy Castellani published April 2014 in Biochemical Pharmacology

Prion disease and Alzheimer's disease: pathogenic overlap

scientific article

Protein Misfolding in Alzheimer's Disease

scholarly article published 3 December 2007

Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine

scientific article published on 24 October 2020

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

scientific article published on 07 March 2009

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

scientific article published in March 1998

Redox active iron accumulation in aceruloplasminemia

scientific article published on 15 February 2008

Redox metals and oxidative abnormalities in human prion diseases

scientific article published on 11 August 2005

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

scientific article

Role of mitochondrial dysfunction in Alzheimer's disease

scientific article

Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy

scientific article published on March 2006

Simultaneous onset of Alzheimer's disease in a husband and wife in their mid-fifties: what do we really know about environmental factors? ⬇️

scientific article

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

scientific article published on 20 May 2008

Sudden unexpected death in lymphocytic hypophysitis.

scientific article published in March 2009

Sulfonylurea receptor 1 expression in human cerebral infarcts

scientific article published on September 2013

Summary of the 2015 University of Michigan Sport Concussion Summit

Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts

scientific article

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy

scientific article published in March 2002

Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges

The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation

scientific article published on 02 October 2009

The Role of the Iron Stain in Assessing Intracranial Hemorrhage

scientific article published on 28 October 2016

The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation

scientific article published on 13 February 2019

The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery

scientific article published on January 2012

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

scientific article

The complexities of the pathology-pathogenesis relationship in Alzheimer disease

scientific article published on 18 January 2014

The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

scientific article published on 22 January 2009

The origin of oxidative stress in neurodegenerative disease: Mark Anthony Smith 1965–2010

The role of iron as a mediator of oxidative stress in Alzheimer disease

scientific article published on 23 March 2012

The role of novel chitin-like polysaccharides in Alzheimer disease

scientific article published on December 2007

Thinking Outside the Box in Alzheimer Disease Treatment

Treatment advances in Alzheimer's disease based on the oxidative stress model

scientific article

Untangling the Vascular Web from Alzheimer Disease and Oxidative Stress ⬇️

scientific article published on January 1, 2012

Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein.

scientific article

Widespread distribution of reticulon-3 in various neurodegenerative diseases

scientific article

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