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List of works by Peter Q Eichacker

A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for B. anthracis infection: A need for more robust study designs and results.

scientific article published on 10 August 2017

Activated protein C in sepsis: emerging insights regarding its mechanism of action and clinical effectiveness

scientific article published on June 2004

An overview of anthrax infection including the recently identified form of disease in injection drug users

scientific article

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model

scientific article

Anthrax infection

scientific article

Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines

scientific article

Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis

scientific article

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs

scientific article published on 15 February 2019

B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components

scientific article

Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model

scientific article published on 24 April 2017

Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model

scientific article

Bacillus anthracis cell wall produces injurious inflammation but paradoxically decreases the lethality of anthrax lethal toxin in a rat model

scientific article

Bacillus anthracis edema but not lethal toxin challenge in rats is associated with depressed myocardial function in hearts isolated and tested in a Langendorff system

scientific article published on 10 April 2015

Beneficial effects of stress-dose corticosteroid therapy in canines depend on the severity of staphylococcal pneumonia

scientific article

Bundled care for septic shock: an analysis of clinical trials

scientific article

Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate

scientific article

Confirmed Bacillus anthracis infection among persons who inject drugs, Scotland, 2009-2010.

scientific article

Correction: A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for B. anthracis infection: A need for more robust study designs and results

scientific article published on 4 December 2017

Defining the standard of care in randomized controlled trials of titrated therapies

scientific article

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice

scientific article

Does Bacillus anthracis Lethal Toxin Directly Depress Myocardial Function? A Review of Clinical Cases and Preclinical Studies

scientific article

Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock

scientific article published on January 2012

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies ⬇️

scientific article published on February 17, 2011

Hydrocortisone decreases lethality and inflammatory cytokine and nitric oxide production in rats challenged with B. anthracis cell wall peptidoglycan

scientific article published on 18 November 2020

Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia

scientific article

Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis

scientific article

Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy

scientific article

Medical guidelines and performance measures: the need to keep them free of industry influence ⬇️

scientific article published on January 1, 2008

Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose

scientific article

Neuronal nitric oxide synthase deficiency decreases survival in bacterial peritonitis and sepsis

scientific article

Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model

scientific journal article

New insights into the pathogenesis and treatment of anthrax toxin-induced shock

scientific article published on June 2007

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

scientific article published on 22 July 2016

Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats

scientific article

Novel therapies for sepsis: a review

scientific article

Practice misalignments in randomized controlled trials: Identification, impact, and potential solutions

scientific article

Protective antigen antibody augments hemodynamic support in anthrax lethal toxin shock in canines

scientific article published on 5 January 2012

Purified cell wall from the probiotic bacterium Lactobacillus gasseri activates systemic inflammation and, at higher doses, produces lethality in a rat model

scientific article

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines

scientific article published on February 2015

Recombinant human activated protein C in sepsis: assessing its clinical use.

scientific article published in October 2004

Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials

scientific article

Risks and benefits of activated protein C treatment for severe sepsis

scientific article published in September 2002

SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice.

scientific article

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

scientific article published on 8 September 2017

Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly

scientific article

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis

scientific article published on 17 February 2020

The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins

scientific article published on 6 December 2017

The effect of heparin administration in animal models of sepsis: A prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies* ⬇️

scientific article published on May 1, 2011

The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death

scientific article

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

scientific article

The individual survival benefits of tumor necrosis factor soluble receptor and fluid administration are not additive in a rat sepsis model ⬇️

scientific article published on August 30, 2011

The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock

scientific article

Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review

scientific article

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