List of works - Shihui Liu

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

scientific article published on October 2006

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

scientific article published on 25 May 2004

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.

scientific article

An anthrax toxin variant with an improved activity in tumor targeting

scientific article published on 20 November 2015

Anthrax Pathogenesis

scientific article published on 16 July 2015

Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting

scientific article published on 23 August 2016

Anthrax edema toxin impairs clearance in mice

scientific article published on 21 November 2011

Anthrax lethal and edema toxins in anthrax pathogenesis

scientific article

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

scientific article

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

scientific article

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

scientific article published on 07 September 2020

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

scientific article

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

scientific article

Anthrax toxin-mediated delivery of the Pseudomonas exotoxin A enzymatic domain to the cytosol of tumor cells via cleavable ubiquitin fusions

scientific article published on 30 April 2013

Anthrax toxin: structures, functions and tumour targeting

scientific article

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation ⬇️

scientific article published on 9 May 2017

BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

scientific article published on September 2005

Bacillus anthracis toxins ⬇️

academic chapter published in The Comprehensive Sourcebook of Bacterial Protein Toxins, 4th edition

Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

scientific article published on 17 April 2019

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

scientific article

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

scientific article

Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

scientific article published on 4 December 2002

Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.

scientific article

Characterization of the interaction between anthrax toxin and its cellular receptors

scientific article published on April 2007

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

scientific article

Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins ⬇️

scientific article

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

scientific article published on February 2013

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

scientific article published on May 2008

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

scientific article

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. ⬇️

scientific article published on December 2004

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin

scientific article

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development

scientific article

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

scientific article

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

scientific article

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

scientific article

Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen

scientific article published on 15 October 2020

Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins

scientific article

Imaging specific cell-surface proteolytic activity in single living cells

scientific article

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

scientific article

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

scientific article

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas

scientific article published on 02 March 2020

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

scientific article published on 24 September 2020

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

scientific article published on 15 May 2005

Key tissue targets responsible for anthrax-toxin-induced lethality

scientific article

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

scientific article published on November 2007

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

scientific article published on April 2009

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

scientific article

Peptide toxins directed at the matrix dissolution systems of cancer cells

scientific article

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF). ⬇️

scientific article

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

scholarly article

Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy

scientific article published on 18 January 2008

Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA

scientific article published on 01 May 2019

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

scientific article

Quickening the pace of anthrax research: three advances point towards possible therapies

scientific article

Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax

scientific article

Recombinant expression and purification of a tumor-targeted toxin in Bacillus anthracis

scientific article published on 27 November 2012

Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor

scientific article

Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins

scientific journal article

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells

scientific article published on 24 January 2007

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

scientific article

Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors

scientific article published on 09 June 2020

Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization

scientific article

Solid tumor therapy by selectively targeting stromal endothelial cells

scientific article published on 29 June 2016

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

scientific article

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

scientific article published on 01 April 2007

Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion.

scientific article published on 09 March 2016

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

scientific article published on 15 September 2015

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network

scientific article

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin ⬇️

scientific article published on 05 May 2008

The receptors that mediate the direct lethality of anthrax toxin

scientific article published on 27 December 2012

Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins

scientific article published on 06 April 2019

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin ⬇️

scientific article published on 01 November 2000

Tumor therapy with a urokinase plasminogen activator-activated anthrax lethal toxin alone and in combination with paclitaxel

scientific article published on 28 July 2012

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

scientific article published in December 2017

List of works by Shihui Liu

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.

An anthrax toxin variant with an improved activity in tumor targeting

Anthrax Pathogenesis

Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting

Anthrax edema toxin impairs clearance in mice

Anthrax lethal and edema toxins in anthrax pathogenesis

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Anthrax toxin-mediated delivery of the Pseudomonas exotoxin A enzymatic domain to the cytosol of tumor cells via cleavable ubiquitin fusions

Anthrax toxin: structures, functions and tumour targeting

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation ⬇️

BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Bacillus anthracis toxins ⬇️

Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.

Characterization of the interaction between anthrax toxin and its cellular receptors

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins ⬇️

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. ⬇️

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen

Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins

Imaging specific cell-surface proteolytic activity in single living cells

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

Key tissue targets responsible for anthrax-toxin-induced lethality

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

Peptide toxins directed at the matrix dissolution systems of cancer cells

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF). ⬇️

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy

Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Quickening the pace of anthrax research: three advances point towards possible therapies

Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax

Recombinant expression and purification of a tumor-targeted toxin in Bacillus anthracis

Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor

Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors

Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization

Solid tumor therapy by selectively targeting stromal endothelial cells

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion.

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin ⬇️

The receptors that mediate the direct lethality of anthrax toxin

Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin ⬇️

Tumor therapy with a urokinase plasminogen activator-activated anthrax lethal toxin alone and in combination with paclitaxel

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake