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List of works by Carlos M. Isales

25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth.

scientific article

A ;C' for the Pancreatic ABCs

scientific article published on 01 August 1998

A Potential Role for Phospholipase-D in the Angiotensin-II-Induced Stimulation of Aldosterone Secretion from Bovine Adrenal Glomerulosa Cells* ⬇️

scientific article published on 01 September 1990

A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line

scientific article published on December 1996

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

scientific article published on 04 July 2013

ACTH is a novel regulator of bone mass

scientific article

ACTH protects against glucocorticoid-induced osteonecrosis of bone

scientific article

AGE-ASSOCIATED INCREASE IN KYNURENINE INHIBITS AUTOPHAGY AND PROMOTES SENESCENCE IN BONE MARROW STEM CELLS

scientific article published on 8 November 2019

AGE-ASSOCIATED INCREASE IN KYNURENINE SUPPRESSES AUTOPHAGY AND PROMOTES APOPTOSIS IN MESENCHYMAL STEM CELLS

scholarly article in Innovation in Aging, vol. 3, Suppl 1, November 2019

Absence of functional leptin receptor isoforms in the POUND (Lepr(db/lb)) mouse is associated with muscle atrophy and altered myoblast proliferation and differentiation

scientific article

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

scientific article published on 30 November 2019

Acetoacetate and beta-hydroxybutyrate differentially regulate endothelin-1 and vascular endothelial growth factor in mouse brain microvascular endothelial cells.

scientific article

Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice.

scientific article published on 8 May 2019

Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cells

scientific article published on July 2008

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

scientific article published on 23 April 2020

Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptin

scientific article published on 05 June 2006

Amino acids as signaling molecules modulating bone turnover

scientific article published on 27 February 2018

Angiotensin-II-induced changes in diacylglycerol levels and their potential role in modulating the steroidogenic response

scientific article published on January 1991

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension

scientific article

Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study

scientific article published on 2 February 2017

Association of Dietary Niacin Intake With Incident Hip Fracture, BMD, and Body Composition: The Cardiovascular Health Study

scientific article published on 19 January 2019

Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture

scientific article published on 04 February 2019

Association of serum thyroid-stimulating hormone with hand grip strength in community-dwelling euthyroid elderly

scientific article published on 01 November 2018

Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

scientific article published on 01 March 1990

Atrial natriuretic peptide enhances activity of potassium conductance in adrenal glomerulosa cells

scientific article published on May 1994

Atrial natriuretic peptide inhibits the stimulation of aldosterone secretion but not the transient increase in intracellular free calcium concentration induced by angiotensin II addition

scientific article published on 01 April 1988

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

scientific article published on 17 January 2019

COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

scientific article published on 09 May 2020

Ca2+ channels and aldosterone secretion: modulation by K+ and atrial natriuretic peptide

scientific article published on 01 October 1991

Cadmium intake and systemic exposure in postmenopausal women and age-matched men who smoke cigarettes

scientific article published on 24 July 2012

Calcium-sensitive probes for the measurement of intracellular calcium: effects of buffer system and magnesium concentration.

scientific article

Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells.

scientific article

Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight.

scientific article

Carboxy-terminal PTH fragments stimulate [3H]thymidine incorporation in vascular endothelial cells.

scientific article

Characterization and phospholipase D mediation of the angiotensin II priming response in adrenal glomerulosa cells.

scientific article

Chemically Defined and Xeno-Free Cryopreservation of Human Adipose-Derived Stem Cells

scientific article

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues

scientific article

Correction: Absence of Functional Leptin Receptor Isoforms in the POUND (Leprdb/lb) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation.

scientific article published on 26 August 2013

Crosstalk between bone marrow-derived mesenchymal stem cells and regulatory T cells through a glucocorticoid-induced leucine zipper/developmental endothelial locus-1-dependent mechanism

scientific article

Cycling of Ca2+ across the plasma membrane as a mechanism for generating a Ca2+ signal for cell activation

scientific article published on 01 January 1989

Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

scientific article published on 19 November 2019

Deletion of PPARγ in Mesenchymal Lineage Cells Protects Against Aging-Induced Cortical Bone Loss in Mice

scientific article published on 15 February 2020

Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo

scientific article published on 12 August 2017

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

scientific article published on 15 December 2015

Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses

scientific article published on October 1995

Differential effects of agonists of aldosterone secretion on steroidogenic acute regulatory phosphorylation.

scientific article

Differentially expressed genes in PPARγ-deficient MSCs.

scientific article published on 31 July 2017

Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss

scientific article published on 27 December 2005

Effect of ANP on sustained aldosterone secretion stimulated by angiotensin II

scientific article published on 01 January 1989

Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.

scientific article

Effect of short-term somatostatin and long-term triiodothyronine administration in a child with nontumorous inappropriate thyrotropin secretion

scientific article published on 01 January 1988

Effect of whole-body vibration on bone properties in aging mice.

scientific article

Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver

scientific article published on 01 January 1992

Effects of glucose-dependent insulinotropic peptide on behavior

scientific journal article

Effects of glucose-dependent insulinotropic peptide on osteoclast function

scientific article published on 26 September 2006

Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells

scientific article published on 21 November 2012

Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

scientific article published on 01 November 2019

Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues

scientific article published on 01 December 2019

Endothelin-1 induces cholestasis which is mediated by an increase in portal pressure

scientific article

Energy Balance, Myostatin, and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone.

scientific article

Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools ⬇️

scientific article published on September 1, 1997

Functional analysis of glucose-dependent insulinotropic polypeptide fusion proteins

scientific article published on April 2001

Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line

scientific article published on September 2000

Future developments in therapy.

scientific article published on 21 June 2007

GRowing an epidermal tumor.

scientific article published on December 2013

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis.

scientific article

Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation.

scientific article

Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects.

scientific article published in May 2001

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

scientific article published on 01 September 2000

Glucose-dependent insulinotropic peptide stimulates proliferation and TGF-beta release from MG-63 cells.

scientific article

Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1 ⬇️

scientific article (publication date: August 2003)

Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass

scientific article published on 20 January 2007

Glucose-dependent insulinotropic peptide: differential effects on hepatic artery vs. portal vein endothelial cells

scientific article published on 6 January 2004

Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

scientific article published on 10 October 2005

High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway.

scientific article published on 30 May 2003

Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells

scientific article published on 01 November 1992

Impact of dietary aromatic amino acids on osteoclastic activity

scientific article

Impact of glucose-dependent insulinotropic peptide on age-induced bone loss

scientific article published on April 2008

Impact of targeted PPARγ disruption on bone remodeling

scientific article published on 7 February 2015

Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents

scientific article published on 01 September 1997

Insulin Resistance Negatively Influences the Muscle-Dependent IGF-1-Bone Mass Relationship in Premenarcheal Girls

scientific article published on 17 November 2015

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9 to 13 Years

scientific article published in July 2017

Inverse relationship between serum hsCRP concentration and hand grip strength in older adults: a nationwide population-based study

scientific article published on 01 August 2018

KYNURENINE, AN ENDOGENOUS AHR AGONIST, UPREGULATES CXCL12- AND HDAC3-TARGETING MIRNAS INHIBITING OSTEOGENESIS

scientific article published on 8 November 2019

Kinase activation and smooth muscle contraction in the presence and absence of calcium

scientific article published on 01 July 1995

Knockdown of SVCT2 impairs in-vitro cell attachment, migration and wound healing in bone marrow stromal cells

scientific article published on 09 November 2013

Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

scientific article published on 26 October 2020

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

scientific article published on 05 December 2019

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

scientific article published on 17 December 2019

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

scientific article published on 20 July 2017

Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation

scientific article published on 13 October 2019

Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading.

scientific article

Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects.

scientific article

Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study

scientific article published on 01 July 2019

Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy

scientific article

Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment

scientific article published on 07 April 2019

MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells

scientific article published on 01 August 2019

MicroRNA-183-5p Increases with Age in Bone-Derived Extracellular Vesicles, Suppresses Bone Marrow Stromal (Stem) Cell Proliferation, and Induces Stem Cell Senescence.

scientific article published on 31 March 2017

MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells

scientific article published on 03 October 2020

MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells

scientific article published on 21 January 2015

Microarray analysis of Tbx2-directed gene expression: a possible role in osteogenesis.

scientific article published on May 2001

Modulation of Ca2+ channels by atrial natriuretic peptide in the bovine adrenal glomerulosa cell

scientific article

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

scientific article

Molecular cloning of a putative tetrodotoxin-resistant sodium channel from dog nodose ganglion neurons ⬇️

scientific article published on November 20, 1997

Monomethylfumarate protects against ovariectomy-related changes in body composition

scientific article published on 01 July 2019

Multiple melanocortin receptors are expressed in bone cells

scientific article

Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice

scientific article published on 01 September 2005

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Negative transcriptional regulation of connexin 43 by Tbx2 in rat immature coronal sutures and ROS 17/2.8 cells in culture

scientific article published on May 2003

Novel effect of insulin: insulin-stimulated Na+ transport is mediated by hydrolysis of phosphoinositides

scientific article published on 01 February 1997

Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

scientific article (publication date: March 2000)

Overexpression of protein kinase C alpha and beta1 has distinct effects on bovine aortic endothelial cell growth

scientific article published in September 1998

Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells

scientific article published on 28 January 2015

PICOLINIC ACID, A TRYPTOPHAN METABOLITE, DOESN’T AFFECT BONE MINERAL DENSITY BUT UPREGULATES LIPID STORAGE GENES

scientific article published on 8 November 2019

Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration

scientific article published on January 2002

Parathyroid hormone modulates angiotensin II-induced aldosterone secretion from the adrenal glomerulosa cell

scientific article published on 01 July 1991

Parathyroid hormone stimulates electrogenic sodium transport in A6 cells

scientific article published on August 1995

Phorbol ester increases mitochondrial cholesterol content in NCI H295R cells

scientific article published on 28 August 2008

Phosphatidylglycerol inhibits toll-like receptor-mediated inflammation by danger-associated molecular patterns

scientific article published on 31 October 2018

Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes

scientific article published on 01 January 1993

Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells

scientific article published on 22 June 2021

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

scientific article published on 20 February 2020

Pine oil effects on chemical and thermal injury in mice and cultured mouse dorsal root ganglion neurons.

scientific article

Pituitary glycoprotein hormone receptors in non-endocrine organs

scientific article published on 27 June 2007

Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy.

scientific article

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow.

scientific article

Removal of pamidronate from bone in rats using systemic and local chelation

scientific article

Resistance to body fat gain in 'double-muscled' mice fed a high-fat diet

scientific article published on 01 May 2006

Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF.

scientific article

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview

scientific article published on 07 December 2018

Role of calcium in angiotensin II-mediated aldosterone secretion.

scientific article

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw

scientific article published on 09 January 2020

Role of glucocorticoid-induced leucine zipper (GILZ) in bone acquisition

scientific article

Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss.

scientific article published on 3 August 2017

SUMO wrestling with type 1 diabetes

scientific article (publication date: July 2005)

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

scientific article published on 10 December 2020

Short term memory in the calcium messenger system. Evidence for a sustained activation of protein kinase C in adrenal glomerulosa cells

scientific article published on September 1986

Signal transduction mechanisms involved in carbachol-induced aldosterone secretion from bovine adrenal glomerulosa cells

scientific article published on 01 July 1992

Skeletal receptors for steroid-family regulating glycoprotein hormones: A multilevel, integrated physiological control system

scientific article published on December 2011

Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells.

scientific article

Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis

scientific article published on 23 August 2012

Special issue: The kynurenine pathway in aging

scientific article published on 03 March 2020

Spontaneous bone loss in RIP-iNOS transgenic mouse: a mouse model for diabetes-mediated osteopenia/osteoporosis

scientific article published on 21 December 2009

Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics

scientific article

Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology

scientific article published on 20 July 2019

Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis

scientific article published on 24 October 2019

Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells.

scientific article

Stromal cell-derived factor-1β potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro

scientific article

Sustained phospholipase D activation in response to angiotensin II but not carbachol in bovine adrenal glomerulosa cells ⬇️

scientific article published on February 15, 1998

Synergistic Effects of Multiple Factors Involved in COVID-19-dependent Muscle Loss

publication published on 01 April 2022

Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion

scientific article

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

scientific article published on 01 May 1996

Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis

scientific article

Tbx2 represses expression of Connexin43 in osteoblastic-like cells.

scientific article published on June 2004

Temporal patterns of protein phosphorylation after angiotensin II, A23187 and/or 12-O-tetradecanoylphorbol 13-acetate in adrenal glomerulosa cells

scientific article published on September 1986

Tension-induced reduction in connexin 43 expression in cranial sutures is linked to transcriptional regulation by TBX2.

scientific article

The Association of Aromatic Amino Acids with Incident Hip Fracture, aBMD, and Body Composition from the Cardiovascular Health Study

scientific article published on 21 May 2019

The Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism

scientific article published on 01 June 2019

The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans.

scholarly article

The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging

scientific article published on 11 September 2020

The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

scientific article published on 26 August 2010

The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

scientific article

The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro

scientific article published on 17 March 2015

The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis.

scientific article

The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat

scientific article published on 01 July 2019

The positive association of total protein intake with femoral neck strength (KNHANES IV).

scientific article published on 6 March 2018

The role of calcium influx pathways in phospholipase D activation in bovine adrenal glomerulosa cells

scientific article published on 16 April 2009

The role of cyclic nucleotides in atrial natriuretic peptide-mediated inhibition of aldosterone secretion.

scientific article published in March 1988

Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis

scientific article

Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation.

scientific article

Vasopressin-induced activation of protein kinase C in renal epithelial cells ⬇️

scientific article published on March 27, 1998

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands

scientific article published on 10 February 2019

Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

scientific article published on 15 March 2017

Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.

scientific article

a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.

scientific article published on 13 September 2013

microRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

scientific article published on 27 August 2010

pH-dependent fluoride transport in intestinal brush border membrane vesicles

scientific article published on 01 July 1998

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