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List of works by Frederick A. Schmitt

"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?

scientific article

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

scientific article published on 21 May 2016

"Preclinical" AD revisited: neuropathology of cognitively normal older adults

scientific article published in August 2000

(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia

scientific article published on 02 June 2016

A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease

scientific article published on January 2006

A Summary Score for the Framingham Heart Study Neuropsychological Battery.

scientific article

A brief instrument to assess treatment response in the patient with advanced Alzheimer disease

scientific article published in October 2009

A brief review of the pharmacologic and therapeutic aspects of memantine in Alzheimer's disease

scientific article published on February 2007

A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging

scientific article published on 19 January 2017

A multicenter evaluation of new treatment efficacy instruments for Alzheimer's disease clinical trials: overview and general results. The Alzheimer's Disease Cooperative Study

scientific article published on January 1, 1997

A practical algorithm for managing Alzheimer's disease: what, when, and why?

scientific article

A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial

scientific article published on January 2013

A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil

scientific article published in May 2006

A systematic review of assessment and treatment of moderate to severe Alzheimer's disease

scientific article

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

scientific article

ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions

scientific article published in October 2006

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis.

scientific article

Acceleration of HIV dementia with methamphetamine and cocaine

scientific article published in February 2001

Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB

scientific article published on January 2009

Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment

scientific article published in October 2006

Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia

scientific article published on January 2013

Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly

scientific article published on 13 June 2006

Age-expanded normative data for the Ruff 2&7 Selective Attention Test: evaluating cognition in older males

scientific article

Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease

scientific article published on 01 October 1999

Alzheimer neuropathologic alterations in aged cognitively normal subjects

scientific article published in April 1999

Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States.

scientific article published on 8 February 2016

Alzheimer's Disease in Down Syndrome

scientific article

Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

scientific article

Alzheimer's disease, dental amalgam and mercury

scientific article published in February 1999

Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment

scientific article

Analyzing the impact of 23 mg/day donepezil on language dysfunction in moderate to severe Alzheimer's disease

scientific article published on 20 June 2011

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

scientific article

Assessing the discriminant ability, reliability, and comparability of multiple short forms of the Boston Naming Test in an Alzheimer's disease center cohort

scientific article

Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease: correlation with cognitive severity

scientific article published in January 1990

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

scientific article published on 8 October 2011

Association between male gender and cortical Lewy body pathology in large autopsy series

scientific article

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer's Disease by Vitamin E and Selenium Trial (PREADViSE).

scientific article published on 20 March 2017

Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE ⬇️

scientific article published on May 15, 2003

Author Response

scientific article published on 01 June 2015

Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease

scientific article

Baseline subjective memory complaints associate with increased risk of incident dementia: the PREADVISE trial

scientific article published in March 2015

Behaviors Characteristic of Autism Spectrum Disorder in a Geriatric Cohort With Mild Cognitive Impairment or Early Dementia

scientific article published on 01 January 2020

Brain arteriolosclerosis

scientific article published on 24 October 2020

Brain donation in normal aging: procedures, motivations, and donor characteristics from the Biologically Resilient Adults in Neurological Studies (BRAiNS) Project

scientific article published in December 2001

Brain pathologies in extreme old age.

scientific article

Brain structural alterations before mild cognitive impairment

scientific article published in April 2007

Brain structure changes over time in normal and mildly impaired aged persons

scientific article published on 20 May 2020

Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.

scientific article published in July 2009

CERAD practice effects and attrition bias in a dementia prevention trial

scientific article

Cancer history associates with a lower burden of dementia and Alzheimer’s‐type neuropathology in autopsied research volunteers

scientific article published in 2021

Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease.

scientific article published on 29 April 2017

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

scientific article published on 16 November 2015

Cerebrovascular pathology in Down syndrome and Alzheimer disease.

scientific article

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

scientific article published on 19 July 2017

Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials

scientific article published on July 2009

Clinical evaluation of global change in Alzheimer's disease: identifying consensus

scientific article

Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings

scientific article published on 23 August 2008

Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

scientific article

Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis.

scientific article published in October 2006

Comparing clinical profiles in Alzheimer's disease and Parkinson's disease dementia

scientific article published on 11 September 2013

Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome?

scientific article

Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: impact on cognitive and physical functioning in Alzheimer disease

scientific article published in April 2007

Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group

scientific article published on November 1, 1992

Critical decline in fine motor hand movements in human aging

scientific article published on 01 October 1999

Dependence as a unifying construct in defining Alzheimer's disease severity

scientific article

Designing a Brief Alzheimer Screen (BAS).

scientific article published in October 2003

Designing a large prevention trial: statistical issues.

scientific article published in January 2004

Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease

scientific article

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

scientific article published on 23 January 2016

Diabetes mitigates the role of memory complaint in predicting dementia risk: Results from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Study

scientific article published on 7 March 2017

Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery

scientific article

Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task

scientific article published on April 2001

Differential reports of pain and depression differentiate mild cognitive impairment from cognitively intact elderly participants

scientific article published on June 2012

Digital Pathology and Image Analysis for Robust High-Throughput Quantitative Assessment of Alzheimer Disease Neuropathologic Changes ⬇️

scientific article published on December 1, 2012

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

scientific article published on 23 May 2015

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy

scientific article published on 14 August 2020

Distinct patterns of default mode and executive control network circuitry contribute to present and future executive function in older adults

scientific article published on 04 April 2019

Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome

scientific article published on 14 October 2020

Does the arousal system contribute to near death experience?

scientific article published in April 2006

Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression

scientific article

Dopaminergic modulation of memory and affective processing in Parkinson depression

scientific article published on 06 July 2013

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

scientific article

Down syndrome, beta-amyloid and neuroimaging

scientific article

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan

scientific article

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.

scientific article published in January 2018

Efficacy of Rivastigmine on Executive Function in Patients with Parkinson's Disease Dementia ⬇️

scientific article published on October 15, 2010

Efficacy of rivastigmine transdermal patch on activities of daily living: item responder analyses.

scientific article

Evaluating rivastigmine in mild-to-moderate Parkinson's disease dementia using ADAS-cog items.

scientific article published on 14 April 2010

Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI

scientific article published on 25 February 2019

Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs. the full SIB in moderate to severe Alzheimer's disease patients participating in a donepezil study

scientific article published on October 2013

Evidence of increased oxidative damage in subjects with mild cognitive impairment.

scientific article

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.

scientific article published in June 2018

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

scientific article

Factors Associated with Unmet Needs among African-American Dementia Care Providers

scientific article published on 22 January 2016

Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome

scientific article published on 25 August 2020

Findings from the National Memory Screening Day program

scientific article published on 30 January 2015

Frontal lobe phosphorus metabolism and neuropsychological function in aging and in alzheimer's disease ⬇️

scientific article published on August 1, 1995

Frontal white matter integrity in adults with Down syndrome with and without dementia

scientific article published on 04 February 2014

Functional human GRIN2B promoter polymorphism and variation of mental processing speed in older adults. ⬇️

scientific article

Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms

scientific article published on 27 February 2016

Genetic Risk of Alzheimer's Disease: Three Wishes Now That the Genie is Out of the Bottle

article published in 2018

Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers

scientific article published on 06 February 2020

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

scientific article published on 12 March 2016

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature

scientific article

Hippocampal sclerosis in advanced age: clinical and pathological features.

scientific article

Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration

scientific article published on January 2014

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

scientific article

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

scientific article published on 9 November 2005

Human cerebral neuropathology of Type 2 diabetes mellitus

scientific article

INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer's Symptomatic Expression (INCREASE), a randomized controlled trial: rationale, study design, and protocol

scientific article published on 30 December 2019

Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach

scientific article published on 18 April 2017

Improving dementia care: the role of screening and detection of cognitive impairment

scientific article

Lewy body pathology in normal elderly subjects

scientific article published on July 2009

Long-term cognitive impact of anticholinergic medications in older adults.

scientific article published in November 2006

Longitudinal assessment of dementia measures in Down syndrome

scientific article published on 14 November 2020

Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease

scientific article published in July 2005

Low sensitivity in clinical diagnoses of dementia with Lewy bodies

scientific article

MRI temporal lobe volume measures and neuropsychologic function in Alzheimer's disease

scientific article

Measuring cognition in advanced Alzheimer's disease for clinical trials

scientific article

Memantine in moderate-to-severe Alzheimer's disease

scientific article published in April 2003

Memory-Related Frontal Brainwaves Predict Transition to Mild Cognitive Impairment in Healthy Older Individuals Five Years Before Diagnosis

scientific article published on 14 December 2020

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis.

scientific article

Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease

scholarly article by Alex M Helman et al published 2019 in Journal of Alzheimer's Disease

Microglial phenotypes in the brains of aging people with Down syndrome and Alzheimer disease

scientific article published on 07 December 2020

Mild cognitive impairment: statistical models of transition using longitudinal clinical data

scientific article

Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons

scientific article

Modeling the time-course of Alzheimer dementia

scientific article

Modelling mini mental state examination changes in Alzheimer's disease

scientific article published in June 2000

Models of progression in AD: predicting disability and costs.

scientific article

Neurodegenerative memory disorders: a potential role of environmental toxins

scientific article

Neuroinflammatory phenotype in early Alzheimer's disease

scientific article published on 9 October 2012

Neuropathologic substrate of mild cognitive impairment

scientific article published in January 2006

Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease

scientific article published on 18 April 2009

Out-of-body experience and arousal

scientific article published in March 2007

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

scientific article published on 22 February 2017

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

scientific article

Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease

scientific article

Pharmacokinetics, Pharmacodynamics, and Safety of Metrifonate in Patients with Alzheimer's Disease ⬇️

scientific article published on March 1, 1998

Plasma Amyloid-β as a Function of Age, Level of Intellectual Disability, and Presence of Dementia in Down Syndrome ⬇️

scientific article published on January 1, 2011

Practice effects in a longitudinal, multi-center Alzheimer's disease prevention clinical trial.

scientific article published on 20 November 2012

Preclinical AD Workgroup staging: pathological correlates and potential challenges.

scientific article published on 19 April 2011

Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition

scientific article

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

scientific article published on 22 June 2020

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease

scientific article

Promoting interactions with basic scientists and clinicians: summary of the panel session

scientific article

Quality of education and memory test performance in older men: the New York University Paragraph Recall Test normative data

scientific article

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

scientific article published on October 2009

Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.

scientific article published on 30 September 2013

Reviews: Effects of transdermal rivastigmine on ADAS-cog items in mild-to-moderate Alzheimer's disease.

scientific article published on December 2010

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

scientific article published on 6 January 2016

Risk factors for transitions from normal to mild cognitive impairment and dementia.

scientific article published in March 2006

Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease

scientific article published on 22 December 2016

Secondary dementia caregiving and its consequences ⬇️

scientific article published on September 1, 2003

Seizures in patients receiving concomitant antimuscarinics and acetylcholinesterase inhibitor

scientific article published on September 1, 1998

Self-Reported Memory Complaints: A Comparison of Demented and Unimpaired Outcomes

scientific article published on March 2016

Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer's Disease with Vitamin E and Selenium Trial

scientific article published on November 2016

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort

scientific article

Self-reported memory complaints: implications from a longitudinal cohort with autopsies

scientific article

Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia.

scientific article published on February 2007

Short-term neuropsychological outcome following Gamma Knife radiosurgery for arteriovenous malformations: a preliminary report

scientific article published on 01 January 1999

Should older adults be screened for dementia?

scientific article published in April 2006

Should older adults be screened for dementia? It is important to screen for evidence of dementia!

scientific article

Single SPECT measures of cerebral cortical perfusion reflect time-index estimation of dementia severity in Alzheimer's disease

scientific article published in January 2000

Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.

scientific article published on 20 February 2018

Spectral and complexity analysis of scalp EEG characteristics for mild cognitive impairment and early Alzheimer's disease.

scientific article

Sugihara causality analysis of scalp EEG for detection of early Alzheimer's disease

scientific article

Synapse stability in the precuneus early in the progression of Alzheimer's disease

scientific article published on January 2013

Synaptic Loss in the Inferior Temporal Gyrus in Mild Cognitive Impairment and Alzheimer's Disease ⬇️

scientific article published on January 1, 2011

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

scientific article published in May 2007

Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease

scientific article

Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease

scientific article

Temporal quantification of Alzheimer's disease severity: 'time index' model.

scientific article

The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project

scientific article published on June 2016

The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia

The characteristics of dementia caregiving onset ⬇️

scientific article published on March 1, 2003

The emotional ramifications of unmet need in dementia caregiving

scientific article published in November 2004

The severe impairment battery: concurrent validity and the assessment of longitudinal change in Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

scientific article

Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis

scientific article published on 01 January 2019

University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology

scientific article

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

scientific article

Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study

scientific article

Visual Arts Education improves self-esteem for persons with dementia and reduces caregiver burden: A randomized controlled trial

scientific article published in January 2018

Vitamin E and all-cause mortality: a meta-analysis

scientific article

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

scientific article

Women at risk for AD show increased parietal activation during a fluency task

scientific article published in April 2002

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