List of works - Joel Freundlich

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

scientific article published on 22 June 2015

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

scientific article published on 14 February 2017

A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA

scientific article published on 19 March 2020

A brief review of recent Charcot-Marie-Tooth research and priorities

scientific article

A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus.

scientific article published on 14 November 2014

A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA

scientific article (publication date: 23 March 2015)

Accessible Machine Learning Approaches for Toxicology

scholarly article published 19 January 2018

Addressing the Metabolic Stability of Antituberculars through Machine Learning.

scientific article published on 14 September 2017

Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin

scientific article published in 2022

Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery

scientific article

Antitubercular Triazines: Optimization and Intrabacterial Metabolism

scientific article published on 08 November 2019

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

scientific article published on 16 June 2013

Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis

scientific article

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery ⬇️

scientific article published on March 21, 2013

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis

scientific article

Combining Computational Methods for Hit to Lead Optimization in Mycobacterium Tuberculosis Drug Discovery ⬇️

scientific article published on October 17, 2013

Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

scientific article

Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis

scientific article (publication date: August 2012)

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

scientific article published on 19 April 2018

Computational Approaches to Identify Molecules Binding to <i>Mycobacterium tuberculosis</i> KasA

scientific article published on 15 November 2020

Computational Models for Tuberculosis Drug Discovery ⬇️

scientific article published on January 1, 2013

Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery

scientific article

Computational models for neglected diseases: gaps and opportunities

scientific article published on 30 August 2013

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

scientific article published on 13 December 2013

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

scholarly article by Manu Anantpadma et al published 31 January 2019 in ACS Omega

Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

scientific article published on 10 April 2017

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models

scientific article

Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 524

article

Essential metabolites of Mycobacterium tuberculosis and their mimics

scientific article

Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.

scientific article published in June 2015

Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis

scientific article published on 19 June 2014

Fusing Dual-Event Data Sets for Mycobacterium tuberculosis Machine Learning Models and Their Evaluation ⬇️

scientific article published on October 30, 2013

Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein

scientific article

In silico repositioning of approved drugs for rare and neglected diseases

scientific article published on March 2011

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

scientific article published on 05 November 2019

Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis

scientific article (publication date: 28 April 2014)

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).

scientific article

Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae

scientific article published on 13 July 2020

Machine learning models identify molecules active against the Ebola virus in vitro

scientific article published on 20 October 2015

Minding the gaps in tuberculosis research

scientific article published on 30 June 2014

Morphological profiling of tubercle bacilli identifies drug pathways of action

scientific article published on 17 July 2020

Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins

scientific article published on 31 July 2017

Naïve Bayesian Models for Vero Cell Cytotoxicity

scientific article published on 29 June 2018

Non-classical transpeptidases yield insight into new antibacterials

scientific article

Novel Pyrimidines as Antitubercular Agents

scientific article published on 8 January 2018

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

scientific article

Novel diaryl ureas with efficacy in a mouse model of malaria.

scientific article published on 20 December 2012

Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

scientific article

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

scientific article

Open drug discovery for the Zika virus

scientific article

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

scientific article published on 24 December 2018

Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data

scientific article

Pruned Machine Learning Models to Predict Aqueous Solubility

scientific article published on 01 July 2020

Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography

scientific article published on 09 April 2020

Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis

scientific article published on 29 July 2019

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection

scientific article published on 21 November 2019

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase ⬇️

scientific article published on December 21, 2012

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

article

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

scientific article published on 8 February 2006

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

scientific article published on 29 September 2005

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

scientific article published on 11 December 2008

The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro

scientific article published on 17 May 2019

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

scientific article

Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets

scientific article

X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

scientific article

List of works by Joel Freundlich

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA

A brief review of recent Charcot-Marie-Tooth research and priorities

A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus.

A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA

Accessible Machine Learning Approaches for Toxicology

Addressing the Metabolic Stability of Antituberculars through Machine Learning.

Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin

Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery

Antitubercular Triazines: Optimization and Intrabacterial Metabolism

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis

Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery ⬇️

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis

Combining Computational Methods for Hit to Lead Optimization in Mycobacterium Tuberculosis Drug Discovery ⬇️

Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

Computational Approaches to Identify Molecules Binding to <i>Mycobacterium tuberculosis</i> KasA

Computational Models for Tuberculosis Drug Discovery ⬇️

Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery

Computational models for neglected diseases: gaps and opportunities

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models

Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 524

Essential metabolites of Mycobacterium tuberculosis and their mimics

Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.

Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis

Fusing Dual-Event Data Sets for Mycobacterium tuberculosis Machine Learning Models and Their Evaluation ⬇️

Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein

In silico repositioning of approved drugs for rare and neglected diseases

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).

Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae

Machine learning models identify molecules active against the Ebola virus in vitro

Minding the gaps in tuberculosis research

Morphological profiling of tubercle bacilli identifies drug pathways of action

Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins

Naïve Bayesian Models for Vero Cell Cytotoxicity

Non-classical transpeptidases yield insight into new antibacterials

Novel Pyrimidines as Antitubercular Agents

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Novel diaryl ureas with efficacy in a mouse model of malaria.

Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets

Open drug discovery for the Zika virus

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data

Pruned Machine Learning Models to Predict Aqueous Solubility

Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography

Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase ⬇️

Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets

X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy