List of works - Miguel A Penalva

A fungal perspective on human inborn errors of metabolism: alkaptonuria and beyond.

scientific article

A lacZ reporter fusion method for the genetic analysis of regulatory mutations in pathways of fungal secondary metabolism and its application to the Aspergillus nidulans penicillin pathway ⬇️

scientific article published on November 1, 1995

A lipid-managing program maintains a stout Spitzenkörper.

scientific article

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety

scientific article published on 01 July 1995

Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps.

scientific article published on March 2002

Acute inactivation of the Aspergillus nidulans Golgi membrane fusion machinery: correlation of apical extension arrest and tip swelling with cisternal disorganization.

scientific article published on 14 June 2013

Adaptation of the Tokuyasu method for the ultrastructural study and immunogold labelling of filamentous fungi.

scientific article published on 27 April 2011

AgtA, the dicarboxylic amino acid transporter of Aspergillus nidulans, is concertedly down-regulated by exquisite sensitivity to nitrogen metabolite repression and ammonium-elicited endocytosis.

scientific article published on 23 January 2009

Ambient pH gene regulation in fungi: making connections.

scientific article published on 03 May 2008

Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor

scientific article published on 01 March 2001

An isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant species

scientific article

An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane

scientific article

Analysis of a novel calcium auxotrophy in Aspergillus nidulans.

scientific article published on 15 May 2010

Arrestin-related proteins mediate pH signaling in fungi.

scientific article

Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes

scientific article

Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

scientific article published on 3 April 2015

Aspergillus nidulans BapH is a RAB11 effector that connects membranes in the Spitzenkörper with basal autophagy.

scientific article published on 30 August 2017

Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane.

scientific article

COPI localizes to the early Golgi in Aspergillus nidulans

scientific article published on 11 December 2018

Carbon regulation of penicillin biosynthesis in Aspergillus nidulans: a minor effect of mutations in creB and creC

scientific article published on 01 February 1995

Cell Biology of Hyphal Growth

scientific article

Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway

scientific article

Characterization of Aspergillus nidulans RabC/Rab6.

scientific article published on 25 February 2011

Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII

scientific article published on 23 December 2019

Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.

scientific article published on January 1987

Conditional inactivation ofAspergillus nidulans sarASAR1uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit

scientific article published on 30 December 2014

Crystal structure of human homogentisate dioxygenase

scientific article published in July 2000

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.

scientific article published on 31 August 2016

Cytoplasmic dynein and early endosome transport

scientific article

Endocytic machinery protein SlaB is dispensable for polarity establishment but necessary for polarity maintenance in hyphal tip cells of Aspergillus nidulans

scientific article

Endocytic recycling via the TGN underlies the polarized hyphal mode of life.

scientific article

Endocytosis in filamentous fungi: Cinderella gets her reward.

scientific article published on October 2010

Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement

scientific article

Erratum: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

scientific article published in Nature

Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH.

scientific article published on 19 October 2007

Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC.

scientific article published in October 2007

Expression of fungal genes involved in penicllin biosynthesis

scientific article published on July 1993

Factors involved in the initiation of phage phi 29 DNA replication in vitro: requirement of the gene 2 product for the formation of the protein p3-dAMP complex.

scientific article published on March 1983

Functional analysis of MCCA and MCCB mutations causing methylcrotonylglycinuria.

scientific article published in November 2003

Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency.

scientific article published on 11 November 2003

Fungal metabolic model for type I 3-methylglutaconic aciduria

scientific article

Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.

scientific article published on 6 April 2007

GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.

scientific article published on 20 November 2014

Genetic dissection of the secretory route followed by a fungal extracellular glycosyl hydrolase

scientific article published on 02 August 2018

Genetic studies on the physiological role of CORVET in Aspergillus nidulans.

scientific article published on 30 March 2017

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

HookA is a novel dynein-early endosome linker critical for cargo movement in vivo.

scientific article

Identification of the guanine nucleotide exchange factor for SAR1 in the filamentous fungal model Aspergillus nidulans

scientific article published on 02 September 2019

Liaison alcaline: Pals entice non-endosomal ESCRTs to the plasma membrane for pH signaling

scientific article

Live-cell imaging of Aspergillus nidulans autophagy: RAB1 dependence, Golgi independence and ER involvement

scientific article published on 8 April 2013

Long-Distance Movement of Aspergillus nidulans Early Endosomes on Microtubule Tracks

scientific article published on 29 October 2008

Maturation of late Golgi cisternae into RabE(RAB11) exocytic post-Golgi carriers visualized in vivo.

scientific article

Molecular Characterization of a Gene Encoding a Homogentisate Dioxygenase from Aspergillus nidulans and Identification of Its Human and Plant Homologues ⬇️

scientific article published on September 8, 1995

Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin.

scientific article published on 5 June 2018

Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements

article

Molecular cloning of the uaY regulatory gene of Aspergillus nidulans reveals a favoured region for DNA insertions ⬇️

scientific article published on December 1, 1991

Mutation and polymorphism analysis of the human homogentisate 1, 2-dioxygenase gene in alkaptonuria patients.

scientific article published on April 1998

Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds.

scientific article

Mutational analysis of the pH signal transduction component PalC of Aspergillus nidulans supports distant similarity to BRO1 domain family members.

scientific article published on 8 June 2005

NapA and NapB are the Aspergillus nidulans Nap/SET family members and NapB is a nuclear protein specifically interacting with importin alpha.

scientific article

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

scientific article

On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction.

scientific article published on February 2000

Organization and dynamics of the Aspergillus nidulans Golgi during apical extension and mitosis.

scientific article

Overlap of nuclear localisation signal and specific DNA-binding residues within the zinc finger domain of PacC.

scientific article published in December 2003

PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32.

scientific article published on 13 August 2007

Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.

scientific article published on 3 December 2008

Preferential localization of the endocytic internalization machinery to hyphal tips underlies polarization of the actin cytoskeleton in Aspergillus nidulans

scientific article published on 07 January 2008

Probing the effect of tip pressure on fungal growth: Application to Aspergillus nidulans

scientific article

Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans

scientific article published on 26 November 2007

Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts

scientific article published in January 2004

Receptor-independent Ambient pH signaling by ubiquitin attachment to fungal arrestin-like PalF.

scientific article published on 5 April 2010

Recognizing gene regulation by ambient pH

scientific article published on 01 October 2003

Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein

scientific article

Regulation of gene expression by ambient pH in filamentous fungi and yeasts

scientific article

Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling

scientific article

Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans

scientific article published on January 2012

Sequences of isopenicillin N synthetase genes suggest horizontal gene transfer from prokaryotes to eukaryotes

article

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

scientific article

Specific DNA recognition by the Aspergillus nidulans three zinc finger transcription factor PacC.

scientific article published in December 1997

Spectrophotometric determination of homogentisate using Aspergillus nidulans homogentisate dioxygenase

scientific article published on 01 February 1997

Structural and functional analysis of mutations in alkaptonuria

scientific article published on 01 September 2000

Structure of protein-containing replicative intermediates of Bacillus subtilis phage phi 29 DNA

scientific article published on 01 January 1982

TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabERAB11.

scientific article

The Aspergillus nidulans peripheral ER: disorganization by ER stress and persistence during mitosis

scientific article

The Aspergillus nidulans syntaxin PepA(Pep12) is regulated by two Sec1/Munc-18 proteins to mediate fusion events at early endosomes, late endosomes and vacuoles

scientific article published on 23 September 2015

The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation.

scientific article

The p25 subunit of the dynactin complex is required for dynein-early endosome interaction

scientific article (publication date: 27 June 2011)

The protein covalently linked to the 5' termini of the DNA of Bacillus subtilis phage phi 29 is involved in the initiation of DNA replication

scientific article published on 01 July 1980

The tip growth apparatus of Aspergillus nidulans

scientific article

Three binding sites for the Aspergillus nidulans PacC zinc-finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter

article

Tracing the endocytic pathway of Aspergillus nidulans with FM4-64.

scientific article published on 15 November 2005

Tracking exocytosis of a GPI-anchored protein in Aspergillus nidulans

scientific article published on 09 September 2020

Transformation in Penicillium chrysogenum

scientific article published in January 1987

Transport of fungal RAB11 secretory vesicles involves myosin-5, dynein/dynactin/p25, and kinesin-1 and is independent of kinesin-3

scientific article

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

scientific article

YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix

scientific article

pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems.

scientific article

List of works by Miguel A Penalva

A fungal perspective on human inborn errors of metabolism: alkaptonuria and beyond.

A lacZ reporter fusion method for the genetic analysis of regulatory mutations in pathways of fungal secondary metabolism and its application to the Aspergillus nidulans penicillin pathway ⬇️

A lipid-managing program maintains a stout Spitzenkörper.

Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety

Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps.

Acute inactivation of the Aspergillus nidulans Golgi membrane fusion machinery: correlation of apical extension arrest and tip swelling with cisternal disorganization.

Adaptation of the Tokuyasu method for the ultrastructural study and immunogold labelling of filamentous fungi.

AgtA, the dicarboxylic amino acid transporter of Aspergillus nidulans, is concertedly down-regulated by exquisite sensitivity to nitrogen metabolite repression and ammonium-elicited endocytosis.

Ambient pH gene regulation in fungi: making connections.

Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor

An isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant species

An ordered pathway for the assembly of fungal ESCRT-containing ambient pH signalling complexes at the plasma membrane

Analysis of a novel calcium auxotrophy in Aspergillus nidulans.

Arrestin-related proteins mediate pH signaling in fungi.

Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes

Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

Aspergillus nidulans BapH is a RAB11 effector that connects membranes in the Spitzenkörper with basal autophagy.

Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane.

COPI localizes to the early Golgi in Aspergillus nidulans

Carbon regulation of penicillin biosynthesis in Aspergillus nidulans: a minor effect of mutations in creB and creC

Cell Biology of Hyphal Growth

Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway

Characterization of Aspergillus nidulans RabC/Rab6.

Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII

Cloning and characterization of the isopenicillin N synthetase gene mediating the formation of the beta-lactam ring in Aspergillus nidulans.

Conditional inactivation ofAspergillus nidulans sarASAR1uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit

Crystal structure of human homogentisate dioxygenase

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.

Cytoplasmic dynein and early endosome transport

Endocytic machinery protein SlaB is dispensable for polarity establishment but necessary for polarity maintenance in hyphal tip cells of Aspergillus nidulans

Endocytic recycling via the TGN underlies the polarized hyphal mode of life.

Endocytosis in filamentous fungi: Cinderella gets her reward.

Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement

Erratum: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH.

Evidence for the direct involvement of the proteasome in the proteolytic processing of the Aspergillus nidulans zinc finger transcription factor PacC.

Expression of fungal genes involved in penicllin biosynthesis

Factors involved in the initiation of phage phi 29 DNA replication in vitro: requirement of the gene 2 product for the formation of the protein p3-dAMP complex.

Functional analysis of MCCA and MCCB mutations causing methylcrotonylglycinuria.

Fungal metabolic model for 3-methylcrotonyl-CoA carboxylase deficiency.

Fungal metabolic model for type I 3-methylglutaconic aciduria

Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway.

GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.

Genetic dissection of the secretory route followed by a fungal extracellular glycosyl hydrolase

Genetic studies on the physiological role of CORVET in Aspergillus nidulans.

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

HookA is a novel dynein-early endosome linker critical for cargo movement in vivo.

Identification of the guanine nucleotide exchange factor for SAR1 in the filamentous fungal model Aspergillus nidulans

Liaison alcaline: Pals entice non-endosomal ESCRTs to the plasma membrane for pH signaling

Live-cell imaging of Aspergillus nidulans autophagy: RAB1 dependence, Golgi independence and ER involvement

Long-Distance Movement of Aspergillus nidulans Early Endosomes on Microtubule Tracks

Maturation of late Golgi cisternae into RabE(RAB11) exocytic post-Golgi carriers visualized in vivo.

Molecular Characterization of a Gene Encoding a Homogentisate Dioxygenase from Aspergillus nidulans and Identification of Its Human and Plant Homologues ⬇️

Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin.

Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements

Molecular cloning of the uaY regulatory gene of Aspergillus nidulans reveals a favoured region for DNA insertions ⬇️

Mutation and polymorphism analysis of the human homogentisate 1, 2-dioxygenase gene in alkaptonuria patients.

Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds.

Mutational analysis of the pH signal transduction component PalC of Aspergillus nidulans supports distant similarity to BRO1 domain family members.

NapA and NapB are the Aspergillus nidulans Nap/SET family members and NapB is a nuclear protein specifically interacting with importin alpha.

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction.

Organization and dynamics of the Aspergillus nidulans Golgi during apical extension and mitosis.

Overlap of nuclear localisation signal and specific DNA-binding residues within the zinc finger domain of PacC.

PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32.

Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.

Preferential localization of the endocytic internalization machinery to hyphal tips underlies polarization of the actin cytoskeleton in Aspergillus nidulans

Probing the effect of tip pressure on fungal growth: Application to Aspergillus nidulans

Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans

Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts

Receptor-independent Ambient pH signaling by ubiquitin attachment to fungal arrestin-like PalF.

Recognizing gene regulation by ambient pH

Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein

Regulation of gene expression by ambient pH in filamentous fungi and yeasts

Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling

Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans

Sequences of isopenicillin N synthetase genes suggest horizontal gene transfer from prokaryotes to eukaryotes