Search filters

List of works by Kazuhiro Iwai

4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.

scientific article published in January 1999

A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction.

scientific article

A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8- alpha beta T cell receptor positive T cells

scientific article published on July 1, 1992

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

scientific article

Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells

scientific article published on 22 September 2011

An ubiquitin ligase recognizing a protein oxidized by iron: implications for the turnover of oxidatively damaged proteins.

scientific article

Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

scientific article published on 17 May 2012

Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer

scientific article published on 01 July 2004

Chemoenzymatic ubiquitination of artificial substrates

scientific article published on 01 November 2006

Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization.

scientific article published in April 2018

Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation

scientific journal article

Crucial Role of Linear Ubiquitin Chain Assembly Complex-Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development

scientific article published on 13 April 2018

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.

scientific article

Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.

scientific article published on 25 December 2009

Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.

scientific article published on 13 August 2013

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

scientific article published on 7 January 2007

Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death

scientific article published on 05 July 2020

Diverse roles of the ubiquitin system in NF-κB activation ⬇️

scientific article published on March 21, 2013

Diverse ubiquitin signaling in NF-κB activation ⬇️

scientific article published on April 28, 2012

Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells

scientific article published on 01 June 1995

Functions of Linear Ubiquitin Chains in the NF-κB Pathway : Linear Polyubiquitin in NF-κB Signaling.

scientific article published on January 2010

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

scientific article

Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).

scientific article published on 17 December 2014

Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates

scientific journal article

HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury

scientific article published on 6 November 2017

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

scientific article

Heme induces ubiquitination and degradation of the transcription factor Bach1

scientific article

Heterogeneity in terms of interleukin 4-dependent regulation of Fc epsilon...receptor/CD23 expression on chronic B-lymphocytic leukemia cells

scientific article published on 01 March 1989

IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

scientific article published on 14 March 2014

IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway ⬇️

scientific article published on April 12, 2013

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase

scientific article published on 01 September 1996

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

scientific article

Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1.

scientific article published on January 2005

Immunoblot analysis of linear polyubiquitination of NEMO.

scientific article

In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone

scientific article published on 01 November 1992

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

scientific article published on 11 October 2016

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins ⬇️

scientific article published on April 28, 1998

Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression.

scientific article

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

scientific article published on 10 June 2015

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

scientific article published in Nature Communications

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO ⬇️

scientific article published on August 2, 2011

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.

scientific article published on 25 January 2012

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction ⬇️

scientific article published on February 4, 2011

Linear polyubiquitin chains: a new modifier involved in NFκB activation and chronic inflammation, including dermatitis.

scientific article published on 15 September 2011

Linear polyubiquitination: a new regulator of NF-kappaB activation.

scientific article published on 19 June 2009

Linear ubiquitin chains: NF-κB signalling, cell death and beyond.

scientific article published on 9 July 2014

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

scientific article published on 24 August 2016

Linear ubiquitination: A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex [Review] ⬇️

scientific article published on May 19, 2012

MDM2 is a novel E3 ligase for HIV-1 Vif.

scientific article published on 07 January 2009

Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human.

scientific article

Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death

scientific article published on 28 August 2019

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.

scientific article published in July 2005

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex.

scientific article published on 27 October 2006

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

scientific article published on 01 July 2003

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

scientific article

NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin

scientific article published on 19 December 2018

Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2.

scientific article published on September 2002

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

scientific article published on 27 December 2017

Possible involvement of iron-induced oxidative insults in neurodegeneration.

scientific article published on 27 December 2014

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

scientific article

Potential biomarkers of fatigue identified by plasma metabolome analysis in rats

scientific article published on 20 March 2015

Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator

scientific article published on 5 January 2016

RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway.

scientific article published on 22 December 2010

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.

scientific article published on 07 October 2013

Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein

scientific article published on 5 July 2016

Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins.

scientific article published on 9 January 2018

Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase

scientific article published on 13 September 2018

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2

scientific article

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system

scientific article published on July 2015

Roles of the NF-κB Pathway in B-Lymphocyte Biology.

scientific article published on 15 August 2015

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

scientific article

Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance

scientific article published on 03 June 2019

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

scientific article

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

scientific article

Stabilization of iron regulatory protein 2, IRP2, by aluminum

scientific article published on 01 November 1999

Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.

scientific article published in October 2004

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

scientific article published on 26 January 2014

Synthesis and Analysis of Linear Ubiquitin Chains ⬇️

scientific article published on 01 January 2012

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

scientific journal article

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

scientific article

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

scientific journal article

The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC

scientific article published on 11 May 2020

The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

scientific article published on 13 October 2015

The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 ⬇️

scientific article published on September 17, 2010

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

scientific article

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.

scientific article published on 20 January 2015

Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.

scientific article published on 4 March 2013

Ubiquitin chain elongation: an intriguing strategy.

scientific article published in October 2014

Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.

scientific article published on 10 September 2007

Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex.

scientific article published on 21 November 2005

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.

scientific article published on 25 July 2017

Unusual heme binding in the bacterial iron response regulator protein: spectral characterization of heme binding to the heme regulatory motif

scientific article

[Recent advance in the understanding of iron metabolism and its role on host defense]

scientific article published on 01 December 2005

Paulina is supported by:

About Paulina

Help