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List of works by Eduardo Tolosa

123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations

scientific article

5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

scientific article published on November 2008

A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease

scientific article

A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse

scientific article published on 21 January 2014

A double-blind, delayed-start trial of rasagiline in Parkinson's disease

scientific article

A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes

scientific article

A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease

scientific article published in March 2004

A genome-wide association study in multiple system atrophy

scientific article published on 14 September 2016

A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism

article

A novel intronic mutation in the DDP1 gene in a family with X-linked dystonia-deafness syndrome

scientific article published in February 2005

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

scientific article published on 14 February 2014

A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): rationale, design, and baseline characteristics

scientific article

A reassessment of risks and benefits of dopamine agonists in Parkinson's disease

scientific article

AFQ056 in Parkinson patients with levodopa-induced dyskinesia: 13-week, randomized, dose-finding study

scientific article

AMPA receptor antagonist LY293558 reverses preproenkephalin mRNA overexpression in the striatum of 6-OHDA-lesioned-rats treated with L-dopa

scientific article published in December 2002

Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder

scientific article published on 8 January 2016

Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study

scientific article published in December 2007

Aggregation of α-Synuclein in the Gonadal Tissue of 2 Patients With Parkinson Disease

scientific article published on 13 March 2017

Alpha- and beta-synuclein expression in Parkinson disease with and without dementia

scientific article published on 17 June 2011

Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism ⬇️

scientific article published on August 1, 2012

Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia

scientific article published in May 2005

An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate

scientific article published on 8 October 2014

An observational study of rotigotine transdermal patch and other currently prescribed therapies in patients with Parkinson's disease

scientific article published on 26 February 2018

Apomorphine and levodopa infusion therapies for advanced Parkinson's disease: selection criteria and patient management

scientific article published on June 2009

Arm swing as a potential new prodromal marker of Parkinson's disease

scientific article published on 19 July 2016

Assessment of cortical degeneration in patients with Parkinson's disease by voxel-based morphometry, cortical folding, and cortical thickness

scientific article published on 6 September 2011

Axial motor clues to identify atypical parkinsonism: A multicentre European cohort study

scholarly article by Carlijn D J M Borm et al published 8 June 2018 in Parkinsonism and Related Disorders

Bilateral subthalamic nucleus lesion reverses L‐dopa‐induced motor fluctuations and facilitates dyskinetic movements in hemiparkinsonian rats ⬇️

scientific article published on February 1, 2004

Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

scientific article published in March 2002

Bilateral subthalamic stimulation monotherapy in advanced Parkinson's disease: Long-term follow-up of patients

scholarly article by Francesc Valldeoriola et al published 18 December 2001 in Movement Disorders

Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study

scientific article published in December 2008

Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease

scientific article published on August 23, 2011

Brainstem raphe and substantia nigra echogenicity in idiopathic REM sleep behavior disorder with comorbid depression

scientific article published in May 2015

Caribbean parkinsonism and other atypical parkinsonian disorders

scientific article

Caveats of Neurodegenerative Risk Stratification in Idiopathic REM Sleep Behavior Disorder by Use of the MDS Research for Prodromal Parkinson's Disease

scientific article

Cerebral basis of visual hallucinations in Parkinson's disease: Structural and functional MRI studies ⬇️

scientific article published on June 25, 2011

Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers

scientific article published on 4 April 2016

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

scientific article published in September 2007

Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia

scientific article published in December 2009

Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease

scientific article

Challenges of modifying disease progression in prediagnostic Parkinson's disease

scientific article published on 15 March 2016

Clinical and Pathological Heterogeneity of Neuronal Intermediate Filament Inclusion Disease

Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers

scientific article published on 12 August 2015

Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease

scientific article

Clinical diagnostic criteria for dementia associated with Parkinson's disease

scientific article published on September 2007

Clinical overview of the synucleinopathies ⬇️

scientific article published on September 1, 2003

Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration

scientific article published on 25 March 2008

Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study

scientific article published on 17 April 2018

Cognitive changes in Parkinson's disease patients with visual hallucinations

scientific article published on 14 March 2007

Cognitive dysfunction and dementia in Parkinson disease

scientific article

Cognitive effects of unilateral posteroventral pallidotomy: a 4-year follow-up study

scientific article published in March 2003

Cognitive impairment and resting-state network connectivity in Parkinson's disease

scientific article published on 28 August 2014

Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease

scientific article published in December 2004

Cortical atrophy patterns in early Parkinson's disease patients using hierarchical cluster analysis

scientific article published on 8 February 2018

Cortical thinning associated with mild cognitive impairment in Parkinson's disease

scientific article published on 7 August 2014

Cortical thinning is associated with disease stages and dementia in Parkinson's disease

scientific article published on 05 March 2013

Criteria for the diagnosis of corticobasal degeneration

scientific article published on January 2013

DAT imaging in drug-induced and psychogenic parkinsonism ⬇️

scientific article published on October 1, 2003

Dementia in Parkinson disease: a proton magnetic resonance spectroscopy study

scientific article published in September 2002

Diagnosis and the premotor phase of Parkinson disease

scientific article published on February 2009

Diagnostic cutoff points for ¹²³I-MIBG myocardial scintigraphy in a Caucasian population with Parkinson's disease

scientific article published on 4 March 2011

Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force

scientific article published on December 2007

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy

scientific article

Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations

scientific article published on 03 December 2009

Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations

scientific article published on 7 May 2015

Donepezil in Parkinson's disease dementia: A randomized, double‐blind efficacy and safety study ⬇️

scientific article published on August 22, 2012

Dopamine receptor D2 intronic polymorphism in patients with Parkinson's disease

scholarly article by Pau Pastor et al published October 1999 in Neuroscience Letters

Dual task interference in psychogenic tremor

scientific article published in October 2007

Dysfunctions of cerebral networks precede recognition memory deficits in early Parkinson's disease

scientific article published on 30 April 2011

Dystonia in Parkinson's disease

scientific article

Eating-induced facial myoclonic dystonia probably due to a putaminal lesion

scientific article published in April 2007

Effect of subthalamic nucleus or entopeduncular nucleus lesion on levodopa-induced neurochemical changes within the basal ganglia and on levodopa-induced motor alterations in 6-hydroxydopamine-lesioned rats

scientific article published on September 2003

Efficacy of levodopa/carbidopa/entacapone versus levodopa/carbidopa in patients with early Parkinson's disease experiencing mild wearing-off: a randomised, double-blind trial

scientific article published on 20 November 2013

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

scientific article

Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study).

scientific article published in February 2011

Expanding the ADCY5 phenotype toward spastic paraparesis: A mutation in the M2 domain

scientific article published on 24 January 2018

Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr

scientific article published on 08 December 2014

Functional brain networks and cognitive deficits in Parkinson's disease

scientific article published on 17 March 2014

Further extension of the H1 haplotype associated with progressive supranuclear palsy

G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies

scientific article

Generalised dystonia with an abnormal magnetic resonance imaging signal in the basal ganglia: a case of adult-onset GM1 gangliosidosis

scientific article published in September 2002

Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder

scientific article published on 21 February 2018

Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia

scientific article published on 15 May 2012

Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy

scientific article published in April 2002

Health-related quality of life in multiple system atrophy

scientific article published in June 2006

High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease

scientific article published on 15 October 2010

Hippocampal head atrophy predominance in Parkinson's disease with hallucinations and with dementia

scientific article published on 24 September 2008

Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

article

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

scientific article

Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions

scientific article published on April 2016

Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes

scientific article published in October 2004

Impulse control disorders in Parkinson's disease

scientific article published in January 2012

Increase in body weight after pramipexole treatment in Parkinson's disease

scientific article published in November 2006

Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-ioflupane injection (DaTscan) imaging

scientific article published on 12 June 2014

Inflammatory profile in LRRK2-associated prodromal and clinical PD

scientific article published on 24 May 2016

Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study

scientific article published in July 2010

Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials

scientific article

Isolated frontal disequilibrium as presenting form of anti-Hu paraneoplastic encephalomyelitis

scientific article

LRRK2 haplotype-sharing analysis in Parkinson's disease reveals a novel p.S1761R mutation

scientific article published on 28 October 2011

LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance

scientific article published in March 2006

Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population

scientific article published on 11 October 2016

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients

scientific article published on 8 February 2018

Late-stage Parkinson's disease: the Barcelona and Lisbon cohort

scientific article published on 22 April 2010

Levodopa in the treatment of Parkinson's disease: current status and new developments

scientific article

Long lasting pure freezing of gait preceding progressive supranuclear palsy: a clinicopathological study

scientific article published in October 2007

Long-term response to continuous duodenal infusion of levodopa/carbidopa gel in patients with advanced Parkinson disease: The Barcelona registry

scientific article published on 19 May 2015

Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorder ⬇️

scientific article published on March 23, 2013

Longitudinal one-year study of levels and stoichiometry of neurofilament heavy and light chain concentrations in CSF in patients with multiple system atrophy

scientific article

Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder

scientific article published on 26 March 2016

MAPT association with REM sleep behavior disorder

scientific article published on 13 January 2017

MRI and cognitive impairment in Parkinson's disease

scientific article

Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial

scientific article published on 20 August 2010

Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants

scientific article

MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder

scientific article published on 13 March 2015

Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder

scientific article published in October 2009

Milestones in atypical and secondary Parkinsonisms

scientific article published on May 2011

Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson's disease

scientific article published on 22 February 2012

Molecular and clinical prodrome of Parkinson disease: implications for treatment

scientific article published on 18 May 2010

Motor and nonmotor heterogeneity of LRRK2-related and idiopathic Parkinson's disease

scientific article

Motor responses of muscles supplied by cranial nerves to subthalamic nucleus deep brain stimuli

scientific article published on 5 December 2006

Movement disorders: advances on many fronts

scientific article

Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy

scientific article

Neuroanatomical correlates of impaired decision-making and facial emotion recognition in early Parkinson's disease

scientific article

Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease

scientific article published in June 2009

Neuropsychological deficits in Parkinson's disease patients with visual hallucinations

scientific article published on September 2006

No evidence of CRHR1 gene involvement in progressive supranuclear palsy

scientific article published on 28 September 2006

Nocturnal paroxysmal dystonia related to a prerolandic dysplasia

Nonlinear dynamic analysis of oscillatory repetitive movements in Parkinson's disease and essential tremor ⬇️

scientific article published on November 15, 2010

Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease

scientific article

Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder

scientific article

Novel haplotypes in 17q21 are associated with progressive supranuclear palsy

scientific article

Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD.

scientific article published on 21 January 2015

Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: A voxel-based diffusion tensor imaging study

scientific article

Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA.

scientific article published on 5 June 2017

Parkinson disease: New guidelines for diagnosis of Parkinson disease

scientific article published on 26 March 2013

Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: a 3-year European multicenter study with repeat [123I]FP-CIT SPECT.

scientific article published on March 2009

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

scholarly article by Angelique di Domenico et al published 12 February 2019 in Stem Cell Reports

Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.

scientific article

Peripheral synuclein tissue markers: a step closer to Parkinson's disease diagnosis

scientific article published in August 2015

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

scientific article (publication date: July 2008)

Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial

scientific article

Premotor signs and symptoms of multiple system atrophy

scientific article published on 19 March 2012

Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry

scientific article

Presynaptic parkinsonism in multiple system atrophy mimicking Parkinson's disease: a clinicopathological case study

scientific article published in July 2002

Prevalence and timeline of nonmotor symptoms in idiopathic rapid eye movement sleep behavior disorder

scientific article published in May 2015

Progress in defining the premotor phase of Parkinson's disease ⬇️

scientific article published on June 15, 2011

Progression of cortical thinning in early Parkinson's disease

scientific article

Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG).

scientific article

Progressive supranuclear palsy and corticobasal degeneration: lumping versus splitting

scientific article published in August 2005

Progressive supranuclear palsy: clinical and genetic aspects

scientific article

Pure akinesia: an unusual phenotype of Hallervorden-Spatz syndrome

scientific article (publication date: November 2003)

Pure autonomic failure with altered dopamine transporter imaging

scientific article

Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder.

scientific article published on May 2008

REM sleep behavior disorder and vocal cord paralysis in Machado‐Joseph disease ⬇️

scientific article published on October 1, 2003

Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations

scientific article

Rapidly progressive diffuse Lewy body disease

scientific article

Red flags for multiple system atrophy

scientific article published in June 2008

Regional vulnerability of hippocampal subfields and memory deficits in Parkinson's disease

scientific article

Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy

scientific article

Role of DAT-SPECT in the diagnostic work up of parkinsonism

scientific article published on July 2007

Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER).

scientific article

Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan).

scientific article

Safety and efficacy of perampanel in advanced Parkinson's disease: a randomized, placebo-controlled study

scientific article

Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration

scientific article

Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study

scientific article published on 28 July 2011

Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study

scientific article published in February 2005

Subclinical nigrostriatal dopaminergic denervation in the cerebellar subtype of multiple system atrophy (MSA-C).

scientific article published on 3 June 2011

Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial

scientific article published on 5 March 2014

Tau and saitohin gene expression pattern in progressive supranuclear palsy

scientific article published in February 2007

The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies

scientific article published on 19 October 2010

The diagnosis of Parkinson's disease

scientific article

The natural history of multiple system atrophy: a prospective European cohort study

scientific article published on 5 February 2013

The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study).

scientific article published in December 2014

The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases

scientific article published on 5 November 2014

The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies

scientific article

Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.

scientific article

Transient arrest of psychogenic tremor induced by contralateral ballistic movements

scientific article published in November 2004

Two-hundred Years Later: Is Parkinson's Disease a Single Defined Entity?

scientific article published in November 2017

UCHL-1 gene in multiple system atrophy: a haplotype tagging approach

scientific article published in October 2005

Use of electroconvulsive therapy in Parkinson disease with residual axial symptoms partially unresponsive to L-dopa: a pilot study

scientific article published in June 2012

Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder

scientific article published on 12 February 2011

Validation of a simple screening tool for early diagnosis of advanced Parkinson’s disease in daily practice: the CDEPA questionnaire.

scientific article

Validation of the "QUICK" questionnaire--a tool for diagnosis of "wearing-off" in patients with Parkinson's disease

scientific article

Validation of the freezing of gait questionnaire in patients with Parkinson's disease

scientific article published in April 2009

White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study

scientific article published on 28 December 2010

White matter hyperintensities, cerebrospinal amyloid-β and dementia in Parkinson's disease

scientific article published on 11 June 2016

l-Dopa/carbidopa intestinal gel and subthalamic nucleus stimulation: Effects on cognition and behavior

scientific article published on 20 October 2017

α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain

scientific article published on 23 February 2018

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