List of works - Lidia Sautebin

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

scientific article

5-Arylidene-2-imino-4-thiazolidinones: design and synthesis of novel anti-inflammatory agents

scientific article

5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan

scientific article published in June 2003

5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration

scientific article published in June 2005

5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein

scientific article published in September 2003

5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock

scientific article published in September 2003

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

scientific article published on 26 April 2013

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

scientific article published on 15 November 2013

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

scientific article

Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo

scientific article published on 13 December 2011

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

scientific article published on 8 October 2010

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

scientific article published on 31 August 2016

Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression

scientific article published on May 2004

Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase ⬇️

scientific article published on March 29, 2011

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cosmetovigilance survey: are cosmetics considered safe by consumers?

scientific article published on 23 September 2005

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

scientific article

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

scientific article published on 31 October 2009

Drug safety information through the internet: the experience of an Italian website

scientific article published in January 2009

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma

scholarly article

Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat.

scientific article published in August 2004

Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice

scientific article

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

scientific article published in Nature Communications

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

scientific article published on 18 December 2013

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

scientific article

Evaluation of cosmetic product exposures reported to the Milan Poison Control Centre, Italy from 2005 to 2010.

scientific article published on 8 November 2012

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

scientific article

Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.

scientific article published on December 2010

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

scientific article

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo ⬇️

scientific article published on 18 February 2011

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis

scientific article published on 2 June 2014

Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits

scientific article published on 6 June 2007

Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

scientific article published on 6 March 2006

Involvement of 5-lipoxygenase in spinal cord injury

scientific article published in September 2005

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock

scientific article published in April 2009

Modeling and biological evaluation of 3,3'-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor

scientific article

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

scientific article

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats

scientific article

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

scientific article published on 11 April 2013

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

scientific article published on 31 October 2011

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

scientific article published in January 2010

Oxalomalate affects the inducible nitric oxide synthase expression and activity

scientific article published on 22 December 2006

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

scientific article published on 24 August 2017

Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.

scientific article

Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation

scientific article published in August 2003

Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice

scientific article published on 17 July 2003

Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton

scientific article

Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton

scientific article

Regulation of prostaglandin generation in carrageenan-induced pleurisy by inducible nitric oxide synthase in knockout mice

scientific article

Relaxant effect of capsazepine in the isolated rat ileum

scientific article published in February 2002

Role of 5-lipoxygenase in the multiple organ failure induced by zymosan

scientific article published on 6 July 2004

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

scientific article

Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy

scientific article

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

scientific article published in June 2009

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

scientific article published on 28 December 2015

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

scientific article published on 4 July 2008

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

scientific article published on 24 July 2008

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes ⬇️

scientific article published on June 21, 2011

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article

The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo ⬇️

scientific article published on March 2, 2012

The role of 5-lipoxygenase and leukotrienes in shock and ischemia-reperfusion injury

scientific article published on 22 January 2007

The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis

scientific article

Understanding the adverse effects of cosmetics: a pilot project in cosmetovigilance

scientific article published in January 2008

Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.

scientific article published on 26 July 2005

Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids

scientific article published on 17 July 2015

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition

scientific article

List of works by Lidia Sautebin

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

5-Arylidene-2-imino-4-thiazolidinones: design and synthesis of novel anti-inflammatory agents

5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan

5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration

5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein

5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression

Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase ⬇️

Correction to Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase-2 Inhibiting Nitric Oxide Donors

Cosmetovigilance survey: are cosmetics considered safe by consumers?

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Drug safety information through the internet: the experience of an Italian website

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma

Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat.

Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

Evaluation of cosmetic product exposures reported to the Milan Poison Control Centre, Italy from 2005 to 2010.

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release

Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo ⬇️

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis

Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits

Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract

Involvement of 5-lipoxygenase in spinal cord injury

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock

Modeling and biological evaluation of 3,3'-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

Oxalomalate affects the inducible nitric oxide synthase expression and activity

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat.

Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation

Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice

Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton

Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton

Regulation of prostaglandin generation in carrageenan-induced pleurisy by inducible nitric oxide synthase in knockout mice

Relaxant effect of capsazepine in the isolated rat ileum

Role of 5-lipoxygenase in the multiple organ failure induced by zymosan

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes ⬇️

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo ⬇️

The role of 5-lipoxygenase and leukotrienes in shock and ischemia-reperfusion injury

The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis

Understanding the adverse effects of cosmetics: a pilot project in cosmetovigilance

Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.

Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition