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List of works by Oliver Werz

1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain

scientific article published on 27 May 2005

3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells

scientific article published on 20 September 2005

4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)

scholarly article by Erden Banoglu et al published May 2016 in European Journal of Medicinal Chemistry

5-Lipoxygenase activation by MAPKAPK-2 and ERKs.

scientific article published in January 2003

5-Lipoxygenase inhibitors: a review of recent developments and patents

scientific article published on March 2010

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

scientific article (publication date: April 2015)

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation

scientific article published on 3 February 2016

5-Lipoxygenase: Cellular Biology and Molecular Pharmacology ⬇️

scientific article published on March 1, 2002

5-Lipoxygenase: regulation of expression and enzyme activity

scientific article published on 18 June 2007

A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein

scientific article published on 03 October 2018

A Metabolic Probe-Enabled Strategy Reveals Uptake and Protein Targets of Polyunsaturated Aldehydes in the Diatom Phaeodactylum tricornutum

scientific article

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection

scientific article

ALOX5 variants associated with susceptibility to human pulmonary tuberculosis

scientific article published on 3 January 2008

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

scientific article published on 5 December 2017

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

scientific article published in February 2002

Algal Oxylipins Mediate the Resistance of Diatoms against Algicidal Bacteria

article by Nils Meyer et al published 4 December 2018 in Marine Drugs

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

scientific article published on 15 November 2013

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action

scientific article

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site

scientific article

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

scientific article

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

scientific article published in 2014

Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions.

scientific article

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

scientific article published on 13 February 2002

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding ⬇️

scientific article published on January 28, 2013

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

scientific article published on 8 October 2010

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

scientific article published on 31 August 2016

Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data

scientific article (publication date: June 2011)

Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference ⬇️

scientific article published on October 5, 2011

Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37.

scientific article published on 8 September 2015

Boswellic acids: biological actions and molecular targets

scientific article published on January 2006

Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis

scientific article

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors

scientific article published on 20 November 2015

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

scientific article published in May 2008

Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.

scientific article

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells

scientific article

Caulerpenyne and related bis-enol esters are novel-type inhibitors of human 5-lipoxygenase

scientific article

Celecoxib inhibits 5-lipoxygenase

scientific article

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid

scientific article published in January 2003

Chemometrics-guided development of a cyclodextrin-modified micellar electrokinetic chromatography method with head-column field amplified sample stacking for the analysis of 5-lipoxygenase metabolites ⬇️

scientific article published on August 4, 2012

Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells

scientific article published on February 2006

Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase ⬇️

scientific article published on March 29, 2011

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production

scientific article

Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes

scientific article published on 13 August 2013

Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]

scholarly article by Daniela de Lucia et al published October 2015 in European Journal of Medicinal Chemistry

Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes

scientific article published on 22 December 2003

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.

scientific article

DNA methylation regulates 5-lipoxygenase promoter activity

scientific article published on January 2003

Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts

scientific article published on 12 April 2017

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

scientific article

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors ⬇️

scientific article published on May 18, 2012

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

scientific article

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors

scientific article published on 15 July 2015

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity

scientific article published in June 2010

Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation

scientific article

Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase

scientific article

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors

scientific article published on 28 July 2016

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase ⬇️

scientific article published on June 27, 2013

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

scientific article published on 31 October 2009

Discovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models

scientific article

Discovery of new potent molecular entities able to inhibit mPGES-1.

scientific article published on 23 October 2017

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol

scientific article published on June 2015

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

scientific article published on 20 February 2017

Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future anti-leukotriene therapy

scientific article

Dual induction of mitochondrial apoptosis and senescence in chronic myelogenous leukemia by myrtucommulone A.

scientific article

ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma

scholarly article

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

scientific article published in Nature Communications

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

scientific article

Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans

Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes

scientific article published on July 2002

Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors

scientific article published on November 2005

From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space

scholarly article by Alexander Klenner et al published 30 November 2011 in Molecular Informatics

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site

scientific article published on 27 December 2005

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

scientific article published on 6 August 2009

Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors

scientific article published on 29 September 2015

Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study

scientific article published on 10 November 2015

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

scientific article published on 4 January 2018

Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman

scientific article published on 7 October 2015

Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions

scientific article published on 28 December 2009

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

scientific article (publication date: 15 December 2002)

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.

scientific article

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo ⬇️

scientific article published on 18 February 2011

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes

scientific article published on March 2002

Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids

scientific article published on 14 September 2007

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

scientific article published on 22 April 2011

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

scientific article

Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense

scientific article published on 31 July 2009

Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds

scientific article published on 13 July 2005

Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening

scientific article

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

scientific article published on 14 September 2016

Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum ⬇️

scientific article published in 2013

In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins ⬇️

scientific article published on October 24, 2012

In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis

scientific article published on 2 June 2014

Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures

scientific article

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase

scientific article published on 17 April 2014

Induction of 5-lipoxygenase activation in polymorphonuclear leukocytes by 1-oleoyl-2-acetylglycerol

scientific article

Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid

scientific article

Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach

scientific article published on 27 November 2013

Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

scientific article

Inhibition of 5-lipoxygenase product synthesis by natural compounds of plant origin

scientific article published on 16 October 2007

Inhibitors of actin polymerisation stimulate arachidonic acid release and 5-lipoxygenase activation by upregulation of Ca2+ mobilisation in polymorphonuclear leukocytes involving Src family kinases

scientific article published in September 2005

Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways

scientific article published on 15 August 2009

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

scientific article published on 11 June 2008

Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro ⬇️

scientific article

Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout

scientific article published in May 2018

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

scientific article

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening

scientific article

Melleolides induce rapid cell death in human primary monocytes and cancer cells

scientific article published on 25 June 2014

Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone

scientific article published on 27 April 2017

Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.

scientific article

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

scientific article published on 30 January 2017

Molecular pharmacological profile of the nonredox-type 5-lipoxygenase inhibitor CJ-13,610.

scientific article published on 14 June 2004

Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent

scientific article published on July 2002

Multi-target approach for natural products in inflammation

scientific article

Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.

scientific article published on 4 December 2013

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo

scientific article

Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9.

scientific article published on January 2008

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats

scientific article

Myxochelin-Inspired 5-Lipoxygenase Inhibitors: Synthesis and Biological Evaluation

scientific article

Myxochelins target human 5-lipoxygenase

scientific article published on 16 February 2015

NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum

scientific article published on 6 September 2017

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

scientific article published on 15 February 2018

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

scientific article published on 19 August 2008

Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

scientific article published on 22 December 2016

On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance

scientific article published on 5 February 2009

Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase

scientific article

Particulate transepithelial drug carriers: barriers and functional polymers

scholarly article in RSC Advances, vol. 2 no. 28, 2012

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders

scientific article published on 26 June 2015

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

scientific article published on 24 August 2017

Pharmacological targeting of membrane rigidity: implications on cancer cell migration and invasion

scholarly article by Simone Braig et al published 5 August 2015 in New Journal of Physics

Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1)

scientific article

Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor

scientific article published on 30 November 2011

Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors

scientific article published on 28 March 2003

Phytochemical profile of the aerial parts of Sedum sediforme and anti-inflammatory activity of myricitrin

scientific article

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article

Pirinixic acids: flexible fatty acid mimetics with various biological activities

scientific article published on 27 August 2015

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

scientific article published on 24 April 2013

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.

scientific article published on 21 January 2016

Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes

scientific article published on 11 February 2015

Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice.

scientific article

Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils

scientific article published on August 11, 2011

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

scientific article

Revealing the macromolecular targets of complex natural products

scientific article published on 2 November 2014

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

scientific article published on 12 February 2015

SAR studies of acidic dual γ-secretase/PPARγ modulators ⬇️

scientific article published on August 6, 2011

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease

scientific article published on 30 December 2014

Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase

scientific article published on 8 February 2017

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

scientific article

Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy

scientific article

Simplified pretubulysin derivatives and their biological effects on cancer cells

scientific article published on 17 January 2014

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor ⬇️

scientific article published on December 25, 2011

Small molecules intercept Notch signaling and the early secretory pathway

scientific article published on 29 September 2013

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

scientific article published on 7 January 2015

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

scientific article published in June 2009

Structure and biosynthetic assembly of gulmirecins, macrolide antibiotics from the predatory bacterium Pyxidicoccus fallax

scientific article published on 6 October 2014

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

scientific article

Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E.

scientific article

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations

scientific article

Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin

scientific article published on April 2004

Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase

scientific article published on 5 June 2015

Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

scientific article published on 29 September 2016

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum

scientific article

Targeting de novo lipogenesis as a novel approach in anti-cancer therapy

scientific article published on 7 November 2017

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes ⬇️

scientific article published on June 21, 2011

Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1

scientific article

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

scientific article

The 5-lipoxygenase promoter is regulated by DNA methylation

scientific article

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains

scientific article published on 6 February 2017

The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.

scientific article

The acylphloroglucinols hyperforin and myrtucommulone A cause mitochondrial dysfunctions in leukemic cells by direct interference with mitochondria.

scientific article

The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro

scientific article

The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation

scientific article published on 6 February 2016

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article

The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo ⬇️

scientific article published on March 2, 2012

The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes

scientific article published on 24 January 2008

Therapeutic options for 5-lipoxygenase inhibitors

scientific article published on 11 July 2006

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

scientific article published on 22 September 2015

Total synthesis of myrtucommulone A.

scientific article published in March 2010

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

scientific article published on 28 December 2016

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition

scientific article

Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages

scientific article published on 12 June 2015

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