List of works - Christina Weinigel

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection

scientific article

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

scientific article published on 15 November 2013

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

scientific article

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

scientific article published on 31 August 2016

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

scientific article

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.

scientific article published on 28 July 2016

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

scientific article published in Nature Communications

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

scientific article published on 17 April 2014

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

scientific article published on 30 January 2017

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

scientific article published on 24 August 2017

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

scientific article published on 24 April 2013

Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase

scientific article published on 8 February 2017

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

scientific article

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum

scientific article

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes

scientific article

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

scientific article

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

scientific article published on 22 September 2015

List of works by Christina Weinigel

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes