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List of works by Magali Cucchiarini

A novel algorithm for a precise analysis of subchondral bone alterations.

scientific article

A review of translational medicine. The future paradigm: how can we connect the orthopedic dots better?

scientific article published on 27 September 2017

Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo

scientific article published on 9 June 2010

Adapted chondrogenic differentiation of human mesenchymal stem cells via controlled release of TGF-β1 from poly(ethylene oxide)-terephtalate/poly(butylene terepthalate) multiblock scaffolds

scientific article published on 9 April 2014

Advances and challenges in gene-based approaches for osteoarthritis

scientific article published on October 2013

Analysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system

scientific article published on 17 October 2007

Analysis of spatial osteochondral heterogeneity in advanced knee osteoarthritis exposes influence of joint alignment

scientific article published on 01 September 2020

Association of Nicotine with Osteochondrogenesis and Osteoarthritis Development: The State of the Art of Preclinical Research

scientific article published on 16 October 2019

Asymptomatic focal calcium pyrophosphate crystal deposition within partially failed repair tissue after matrix-assisted autologous chondrocyte implantation

scientific article published on 10 September 2018

Autologous Matrix-Induced Chondrogenesis: A Systematic Review of the Clinical Evidence

scientific article

Basic science of osteoarthritis

scientific article published on 13 September 2016

Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis

scientific article published on 9 May 2012

Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment

scientific article published on 15 June 2016

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects

scientific article published on 14 May 2017

Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I.

scientific article

Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer

article

Clinical potential and challenges of using genetically modified cells for articular cartilage repair

scientific article

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

scientific article published on February 2016

Comprehensive analysis of translational osteochondral repair: Focus on the histological assessment

scientific article

Controlled Gene Delivery Systems for Articular Cartilage Repair

article

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy

scientific article published on 09 April 2020

Controlled release strategies for rAAV-mediated gene delivery

scientific article published on 12 October 2015

Current perspectives in stem cell research for knee cartilage repair

scientific article published on 16 January 2014

Current progress in stem cell-based gene therapy for articular cartilage repair

scientific article published on January 2015

Determination of the chondrogenic differentiation processes in human bone marrow-derived mesenchymal stem cells genetically modified to overexpress transforming growth factor-β via recombinant adeno-associated viral vectors

scientific article published on December 2014

Direct FGF-2 gene transfer via recombinant adeno-associated virus vectors stimulates cell proliferation, collagen production, and the repair of experimental lesions in the human ACL.

scientific article published on 19 November 2012

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

scientific article published on 13 November 2012

Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair.

scientific article published on 27 March 2017

Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: Analysis of the lateral meniscus

scientific article

Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part II: standard and overcorrection do not cause articular cartilage degeneration

scientific article published on 23 January 2013

Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus

scientific article published on 14 June 2014

Effect of subchondral drilling on the microarchitecture of subchondral bone: analysis in a large animal model at 6 months

scientific article published on 5 January 2012

Effective Remodelling of Human Osteoarthritic Cartilage by sox9 Gene Transfer and Overexpression upon Delivery of rAAV Vectors in Polymeric Micelles.

scientific article

Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency

scientific article published on 21 February 2015

Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells

scientific article published on July 2012

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates

scientific article published on 07 February 2017

Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment

scientific article published on 07 October 2019

Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates

scientific article published on 29 July 2016

Effects of solid acellular type-I/III collagen biomaterials on in vitro and in vivo chondrogenesis of mesenchymal stem cells

scientific article

Enamel matrix derivative inhibits proteoglycan production and articular cartilage repair, delays the restoration of the subchondral bone and induces changes of the synovial membrane in a lapine osteochondral defect model in vivo

scientific article published on 2 May 2012

Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer

scientific article published on 21 March 2020

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis

scientific article

Fibroblast growth factor-2-overexpressing myoblasts encapsulated in alginate spheres increase proliferation, reduce apoptosis, induce adipogenesis, and enhance regeneration following skeletal muscle injury in rats

scientific article

Gene Therapy for Cartilage Repair

scientific article published on July 2011

Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspectives

article

Gene therapy for cartilage defects

scientific article

Gene therapy for human osteoarthritis: principles and clinical translation

scientific article

Gene- and Stem Cell-Based Approaches to Regulate Hypertrophic Differentiation in Articular Cartilage Disorders

scientific article

Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery

scientific article

Genetic modification of mesenchymal stem cells for cartilage repair ⬇️

scientific article published on January 1, 2010

Human gene therapy: novel approaches to improve the current gene delivery systems

scientific article published in June 2016

Human mesenchymal stem cells overexpressing therapeutic genes: from basic science to clinical applications for articular cartilage repair

scientific article published on January 2012

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair

scientific article published on 23 August 2016

Hydrogels for precision meniscus tissue engineering: a comprehensive review

scientific article published on 4 January 2017

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors

scientific article published on 21 June 2017

Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle

scientific article published on 27 June 2013

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells

scientific article published on 27 August 2014

Large animal models in experimental knee sports surgery: focus on clinical translation

scientific article

Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo

scientific article published in December 2004

Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics

scientific article

Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2.

scientific article

New cell engineering approaches for cartilage regenerative medicine

scientific article

New trends in articular cartilage repair

scientific article

Nonviral gene transfer into human meniscal cells. Part II: effect of three-dimensional environment and overexpression of human fibroblast growth factor 2.

scientific article

Nonviral gene transfer to human meniscal cells. Part I: transfection analyses and cell transplantation to meniscus explants

scientific article published on 25 June 2014

Overexpression of TGF-β via rAAV-Mediated Gene Transfer Promotes the Healing of Human Meniscal Lesions Ex Vivo on Explanted Menisci

scientific article published on 2 February 2015

PEO-PPO-PEO Carriers for rAAV-Mediated Transduction of Human Articular Chondrocytes in Vitro and in a Human Osteochondral Defect Model

scientific article published on 12 July 2016

PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine-An Overview.

scientific article

PEO-PPO-PEO micelles as effective rAAV-mediated gene delivery systems to target human mesenchymal stem cells without altering their differentiation potency

scientific article published on 27 August 2015

Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes

scientific article published on 3 May 2017

Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system

scientific article published on 24 May 2016

Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage

scientific article published in March 2003

Reduction of sample size requirements by bilateral versus unilateral research designs in animal models for cartilage tissue engineering

scientific article published on 25 April 2013

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells

scientific article published on 28 August 2019

Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer

scientific article published in August 2009

Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9

scientific article published on 01 January 2007

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

scientific article published on January 2012

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

scientific article published on 04 November 2019

Small-Diameter Awls Improve Articular Cartilage Repair After Microfracture Treatment in a Translational Animal Model

scientific article published on 6 November 2015

Smart and Controllable rAAV Gene Delivery Carriers in Progenitor Cells for Human Musculoskeletal Regenerative Medicine with a Focus on the Articular Cartilage

scientific article published on 10 May 2017

Subchondral drilling for articular cartilage repair: a systematic review of translational research.

scientific article published on 3 May 2018

Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery

article

Supramolecular polypseudorotaxane gels for controlled delivery of rAAV vectors in human mesenchymal stem cells for regenerative medicine

scientific article published on 25 May 2017

Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system

scientific article

TGF-β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates

scientific article published on 25 January 2016

The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells

scientific article

Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes

scientific article published on 25 June 2020

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells.

scientific article published on 27 May 2019

Thermosensitive Hydrogel Based on PEO-PPO-PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects

scientific article published on 25 November 2019

Tissue engineering for articular cartilage repair--the state of the art.

scientific article published on 02 May 2013

Tissue-engineering strategies to repair joint tissue in osteoarthritis: nonviral gene-transfer approaches

scientific article published on October 2014

Topographic modeling of early human osteoarthritis in sheep

scientific article published on 01 September 2019

Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineering

scientific article published on 12 August 2013

Translational applications of photopolymerizable hydrogels for cartilage repair

scientific article published on 05 December 2019

Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo

scientific article published on 25 February 2011

Use of tissue engineering strategies to repair joint tissues in osteoarthritis: viral gene transfer approaches

scientific article published on October 2014

rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ

scientific article

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

scientific article published on 28 April 2020

rAAV-mediated combined gene transfer and overexpression of TGF-β and SOX9 remodels human osteoarthritic articular cartilage

scientific article

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

scientific article published on 13 September 2013

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model

scientific article published on 19 September 2017

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