List of works - G.Enrico Rovati

4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.

scientific article published on July 1998

A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate

scientific article

A potential role of PUFAs and COXIBs in cancer chemoprevention.

scientific article published on 20 April 2015

A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.

scientific article

Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.

scientific article published on 17 November 2004

Antagonism of thromboxane receptors by diclofenac and lumiracoxib

Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation

scientific article published on 23 August 2019

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

scientific article published on 22 June 2018

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

scholarly article by Massimo Bertinaria et al published 26 November 2012 in ChemMedChem

CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation.

scientific article published in December 2005

CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.

scientific article published on April 2004

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

scientific article

Cysteinyl-leukotriene receptors and cellular signals.

scientific article

Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.

scientific article published on July 2007

Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma.

scientific article published on 28 July 2006

DESIGN: computerized optimization of experimental design for estimating Kd and Bmax in ligand binding experiments. I. Homologous and heterologous binding to one or two classes of sites.

scientific article published in November 1988

Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure

scientific article

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

scientific article

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

scientific article published on 17 September 2019

Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

scientific article published on 01 February 1994

Eicosanoid release and mepyramine, LTC4 and LTD4 binding in passively sensitized human lung parenchyma in vitro ⬇️

scientific article published on July 5, 1991

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

scientific article

Functional characterization of E. coli LptC: interaction with LPS and a synthetic ligand.

scientific article published on March 2014

Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma

scientific article

Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.

scientific article published on 9 March 2009

Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor

scientific article published on 01 January 1992

Identification of specific binding sites for leukotriene C4 in membranes from human lung

scientific article published on 01 August 1985

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

scientific article

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.

scientific article

Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells ⬇️

scientific article published on July 1, 2003

Leukotrienes as mediators of asthma.

scientific article

Ligand-binding studies: old beliefs and new strategies

scientific article published on 01 September 1998

Light on the structure of thromboxane A₂receptor heterodimers.

scientific article

Lower efficacy: interaction with an inhibitory receptor or partial agonism?

scientific article published in May 1994

MacELLIPSE, a graphical aid to the problem of the joint confidence region: a practical example for ligand binding experiments

scientific article published on 01 December 1993

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

scientific article published on 5 March 2008

Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.

scientific article published on 30 June 2004

Non-serotonergic 3H-ketanserin binding sites in human platelets: characteristics and interaction with calcium antagonists

scientific article published on 01 September 1992

Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk.

scientific article published in January 2017

Optimization of experimental design for ligand binding studies: improved estimation of affinity and binding capacity

scientific article published on 01 November 1989

Pharmacogenetics of the G protein-coupled receptors

scientific article

Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vasc

scientific article published on 6 January 2006

Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro

scientific article

Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.

scientific article

Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors.

scientific article published in November 1992

Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain

scientific article published on 30 October 2019

Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents.

scientific article published on 24 June 2013

The DRY motif and the four corners of the cubic ternary complex model.

scientific article published on 24 March 2017

The DRY motif at work: the P2Y12receptor case

scientific article published on 01 May 2014

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

scientific article published on 27 December 2006

The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field.

scientific article

The many faces of binding artefacts

scientific article published on 01 May 2000

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor

scientific article

Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.

scientific article published in August 2003

Transcellular biosynthesis of eicosanoid lipid mediators

scientific article

Two-Pronged Approach to Anti-Inflammatory Therapy Through the Modulation of the Arachidonic Acid Cascade

scientific article published on 11 October 2018

Working hypothesis on the classification of Cys-leukotriene receptors in airways.

scientific article published in May 1997

List of works by G.Enrico Rovati

4-Oxystilbene compounds are selective ligands for neuronal nicotinic alphaBungarotoxin receptors.

A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate

A potential role of PUFAs and COXIBs in cancer chemoprevention.

A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.

Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.

Antagonism of thromboxane receptors by diclofenac and lumiracoxib

Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation.

CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

Cysteinyl-leukotriene receptors and cellular signals.

Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.

Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma.

DESIGN: computerized optimization of experimental design for estimating Kd and Bmax in ligand binding experiments. I. Homologous and heterologous binding to one or two classes of sites.

Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity

Eicosanoid release and mepyramine, LTC4 and LTD4 binding in passively sensitized human lung parenchyma in vitro ⬇️

Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.

Functional characterization of E. coli LptC: interaction with LPS and a synthetic ligand.

Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma

Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.

Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor

Identification of specific binding sites for leukotriene C4 in membranes from human lung

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.

Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells ⬇️

Leukotrienes as mediators of asthma.

Ligand-binding studies: old beliefs and new strategies

Light on the structure of thromboxane A₂receptor heterodimers.

Lower efficacy: interaction with an inhibitory receptor or partial agonism?

MacELLIPSE, a graphical aid to the problem of the joint confidence region: a practical example for ligand binding experiments

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity.

Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling.

Non-serotonergic 3H-ketanserin binding sites in human platelets: characteristics and interaction with calcium antagonists

Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk.

Optimization of experimental design for ligand binding studies: improved estimation of affinity and binding capacity

Pharmacogenetics of the G protein-coupled receptors

Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vasc

Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro

Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.

Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors.

Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain

Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents.

The DRY motif and the four corners of the cubic ternary complex model.

The DRY motif at work: the P2Y12receptor case

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

The leukotriene receptor antagonist montelukast and its possible role in the cardiovascular field.

The many faces of binding artefacts

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor

Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation.

Transcellular biosynthesis of eicosanoid lipid mediators

Two-Pronged Approach to Anti-Inflammatory Therapy Through the Modulation of the Arachidonic Acid Cascade

Working hypothesis on the classification of Cys-leukotriene receptors in airways.