List of works by Inge Grundke-Iqbal

A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).

scientific article published on 14 November 2012

Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration

scientific article published on January 2013

Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease

scientific article published on 02 May 2013

Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease

scientific article

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

scientific article

Alzheimer's disease, a multifactorial disorder seeking multitherapies ⬇️

scientific article published on September 1, 2010

An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide

scientific article published on 15 November 2011

Anesthesia induces phosphorylation of tau

scientific article

Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

scientific article published on 2 March 2006

Beneficial Effect of a CNTF Tetrapeptide on Adult Hippocampal Neurogenesis, Neuronal Plasticity, and Spatial Memory in Mice ⬇️

scientific article published on January 1, 2010

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

scientific article published in January 2005

Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease

scientific article

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease

scientific article

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

scientific article published on 31 July 2009

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

scientific article published on 22 January 2013

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease

scientific article

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeability

scientific article

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

scientific article published in October 2005

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease

scientific article

Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.

scientific article

Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly

scientific article published on August 2008

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

scientific article published on April 2008

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

scientific article

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

scientific article published on 19 May 2011

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

scientific journal article

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

scientific article published on 15 November 2004

Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain

scientific journal article

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases ⬇️

scientific article published on 13 January 2009

Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation

scientific article (publication date: 2012)

Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective

scientific article published on January 2006

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

scientific article published on 20 March 2007

Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells

scientific article

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

scientific article

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion

scientific article

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

scientific article published on 08 October 2009

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

scientific article

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

scientific article

Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells

scientific article

Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients

scientific article published in March 2002

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

scientific article

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

scientific article published on 19 September 2009

Failure of neuronal maturation in Alzheimer disease dentate gyrus

scientific article

I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A

scientific journal article

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

scientific article

In vitro analysis of tau phosphorylation sites and its biological activity.

scientific article

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

scientific article

Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats

scientific article published on January 2015

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

scientific article published in April 2003

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

scientific article published on January 2005

Inhibitors of protein phosphatase-2A: topography and subcellular localization

scientific article published in July 2004

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

scientific article (publication date: 23 October 2002)

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

scientific article

Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay

scientific article published on April 2002

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

scientific article published in February 2001

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET

scientific article

Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies

scientific article published on August 2008

Mechanisms of tau-induced neurodegeneration

scientific article

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

article

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment

scientific article

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

scientific article

Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies

scientific article

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.

scientific article published in January 2005

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.

scientific article published in June 2002

Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures

scientific article

Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

scientific article published on 30 June 2010

Novel therapeutic strategies for neurodegenerative disease

scientific article published on June 2009

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

scientific article

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

scientific article published on September 2003

Opportunities and challenges in developing Alzheimer disease therapeutics

scientific article published on 30 September 2011

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

scientific article published on 28 May 2008

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

scientific article

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

scientific article published in January 2010

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

scientific article published on 19 September 2014

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

scientific article published on 10 August 2010

Pharmacological approaches of neurofibrillary degeneration

scientific article

Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration ⬇️

scientific article published on July 27, 2010

Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1.

scientific article published in February 2005

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

scholarly article

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

scientific article

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

scientific article

Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice

scientific article published on January 2011

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

scientific article

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

scientific article

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells

scientific article

Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

scientific article

Regulation of phosphorylation of tau by protein kinases in rat brain

scientific article

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

scientific journal article

Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome

scientific article published in December 2011

Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease

scientific article published in February 2002

Role of protein kinase B in Alzheimer's neurofibrillary pathology

scientific article published on 18 December 2002

Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport

scientific article published on 9 March 2004

Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats

scientific article

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

scientific article

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

scientific article

Splicing factor SC35 promotes tau expression through stabilization of its mRNA.

scientific article

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.

scientific article published in November 2005

Targeting tau protein in Alzheimer's disease

scientific article published on May 2010

Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain

scientific article published on 15 September 2004

Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification

scientific article

Tau pathology in Alzheimer disease and other tauopathies

scientific article

Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam

scientific article published on 06 January 2014

The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

scientific article published on 22 July 2010

The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease

scientific article published on 19 November 2002

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

scientific article published on 21 July 2006

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

scientific article

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

scientific article published on 25 May 2002

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

scientific article

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease

scientific article published in December 2002

Paulina is supported by:

About Paulina

Help