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List of works by Jean Claude Reubi

'Running on empty'.

scientific article published on 24 April 2010

111In-DOTASomatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study ⬇️

scientific article published on June 9, 2012

177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer.

scientific article published on July 2006

64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats

scientific article published in April 2014

68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5.

scientific article

A Critical Evaluation of sst3 and sst5 Immunohistochemistry in Human Pituitary Adenomas.

scientific article published on 7 April 2017

A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors

scientific article published on December 2002

AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients

Absence of somatostatin SST(2) receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model

scientific article published on 16 July 2010

Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways

scientific article

Approaches to Multireceptor Targeting: Hybrid Radioligands, Radioligand Cocktails, and Sequential Radioligand Applications

scientific article published in September 2017

Approaches to improve metabolic stability of a statine-based GRP receptor antagonist

scientific article published on 4 November 2016

Biodistribution and catabolism of 18F-labeled neurotensin(8–13) analogs ⬇️

scientific article published on January 1, 2002

Biodistribution of [111In-DTPA-d-Phe1]-octreotide in dogs: uptake in the stomach and intestines but not in the spleen points towards interspecies differences ⬇️

scientific article published on April 1, 2003

Bombesin Antagonist–Based Radioligands for Translational Nuclear Imaging of Gastrin-Releasing Peptide Receptor–Positive Tumors ⬇️

scientific article published on November 11, 2011

CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours

scientific article

CRF receptors in the rodent and human cardiovascular systems: species differences

scientific article published on 21 August 2006

Candidates for peptide receptor radiotherapy today and in the future.

scientific article

Characterization of a novel five-transmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors ⬇️

scientific article published on October 25, 2011

Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT Within Patients with Gastroenteropancreatic Neuroendocrine Tumors ⬇️

scientific article published on January 7, 2013

Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607.

scientific article

Comparison of somatostatin receptor agonist and antagonist for peptide receptor radionuclide therapy: a pilot study

scientific article published on 24 June 2014

Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy.

scientific article published on 29 August 2012

Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting ⬇️

scientific article published on April 18, 2003

Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors: Molecular basis for dual targeting of tumoral vasculature ⬇️

scientific article published on May 13, 2011

Conformational analysis of a potent SSTR3-selective somatostatin analogue by NMR in water solution

scientific article

Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues

scientific article

DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours

scientific article published on 30 January 2007

Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting

scientific article

Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours

scientific article published on 18 August 2010

Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue

scientific article

Distribution of the VPAC2 receptor in peripheral tissues of the mouse

scientific article published on 14 November 2003

Distribution pattern of 68Ga-DOTATATE in disease-free patients

scientific article published in December 2010

Does somatostatin or gastric inhibitory peptide receptor expression correlate with tumor grade and stage in gut neuroendocrine tumors?

scientific article published on 12 January 2015

Early over-expression of GRP receptors in prostatic carcinogenesis

scientific article

Ectopic growth hormone-releasing hormone secretion by a metastatic bronchial carcinoid tumor: a case with a non hypophysial intracranial tumor that shrank during long acting octreotide treatment

scientific article

Erratum to: 64Cu- and 68Ga-Labelled [Nle14,Lys40(Ahx-NODAGA)NH2]-Exendin-4 for Pancreatic Beta Cell Imaging in Rats

scholarly article published in Molecular Imaging and Biology

Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides

scientific article published on 11 August 2009

Evaluation of three different families of bombesin receptor radioantagonists for targeted imaging and therapy of gastrin releasing peptide receptor (GRP-R) positive tumors

scientific article

Evolution of Bombesin Conjugates for Targeted PET Imaging of Tumors ⬇️

scientific article published on September 14, 2012

Expression of functional neurokinin-1 receptors in regenerative glands during gastric wound healing in rodents

scientific article published in March 2004

First clinical evidence that imaging with somatostatin receptor antagonists is feasible

scientific article published on 18 August 2011

GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting

scientific article

GLP-2 receptors in human disease: High expression in gastrointestinal stromal tumors and Crohn’s disease ⬇️

scientific article published on August 19, 2012

GPR87 is an overexpressed G-protein coupled receptor in squamous cell carcinoma of the lung

scientific article

Gastrin in Gastrointestinal Diseases ⬇️

scientific article published on July 20, 2011

Gastrin-releasing peptide receptors in normal and neoplastic human uterus: involvement of multiple tissue compartments

scientific article published on 7 June 2005

Glucagon-like peptide 1-receptor scans to localize occult insulinomas

scientific article published in August 2008

Glucagon-like peptide-1 receptor imaging for localization of insulinomas

scientific article published on 9 October 2009

Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study

scientific article published on 25 July 2013

Glucagon-like peptide-1 receptor overexpression in cancer and its impact on clinical applications

scientific article published on 6 December 2012

Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas

scientific article published on 16 June 2011

Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review

scientific article published on December 2010

High expression of gastrin-releasing peptide receptors in the vascular bed of urinary tract cancers: promising candidates for vascular targeting applications

scientific article published in June 2009

High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia

scientific article

High expression of peptide receptors as a novel target in gastrointestinal stromal tumours

scientific article published on 18 February 2004

Highly Increased 125I-JR11 Antagonist Binding In Vitro Reveals Novel Indications for sst2 Targeting in Human Cancers.

scientific article

Highly efficient in vivo agonist-induced internalization of sst2 receptors in somatostatin target tissues

scientific article published on 14 May 2009

Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities

scientific article

Illuminating somatostatin analog action at neuroendocrine tumor receptors

scientific article published on 31 October 2013

Improvement of pharmacokinetics of radioiodinated Tyr(3)-octreotide by conjugation with carbohydrates

scientific article published in September 2002

In Vitro Evaluation of Molecular Tumor Targets in Nuclear Medicine: Immunohistochemistry Is One Option, but Under Which Conditions?

scientific article

Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: relevance for incretin-based diabetes therapy

scientific article published on 2 September 2011

Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists.

scientific article published on March 2006

Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients

scientific article

Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p.

scientific article published on June 2006

Localization of Hidden Insulinomas with ⁶⁸Ga-DOTA-Exendin-4 PET/CT: A Pilot Study

scientific article

Modulation of pharmacokinetics of radioiodinated sugar-conjugated somatostatin analogues by variation of peptide net charge and carbohydration chemistry

scientific article

N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation

scientific article

N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function

scientific article published on 16 August 2011

N-terminal modifications improve the receptor affinity and pharmacokinetics of radiolabeled peptidic gastrin-releasing peptide receptor antagonists: examples of 68Ga- and 64Cu-labeled peptides for PET imaging

scientific article published on 21 August 2014

N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo

scientific article

NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors

scientific article

NPY receptors in human cancer: a review of current knowledge

scientific article published on 16 January 2007

Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer.

scientific article published in May 2003

Neuropeptide Y acts within the rat testis to inhibit testosterone secretion

scientific article

Neuropeptide Y receptor expression in human primary ovarian neoplasms

scientific article published on January 2004

Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors

scientific article published in August 2008

Neurotensin receptors in pancreatic ductal carcinomas

scientific article

New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting

scientific article

New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold

scientific article published on 9 June 2007

Novel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers ⬇️

scientific article published on September 2, 2011

Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors

scientific article published on August 2010

Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan

scientific article published on December 2003

Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.

scientific article

Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling

scientific article published on December 2003

Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.

scientific article

Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR

scientific article published on July 2006

Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships

scientific article published on 23 January 2008

Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues

scientific article published on May 2009

Old and new peptide receptor targets in cancer: future directions

scientific article published on January 2013

On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY.

scientific article published on May 2011

Overexpression of gastrin-releasing peptide receptors in tumor-associated blood vessels of human ovarian neoplasms.

scientific article

PEG spacers of different length influence the biological profile of bombesin-based radiolabeled antagonists

scientific article published on 29 March 2014

PET of Somatostatin Receptor–Positive Tumors Using 64Cu- and 68Ga-Somatostatin Antagonists: The Chelate Makes the Difference ⬇️

scientific article published on June 16, 2011

PET/CT Imaging of Unstable Carotid Plaque with 68Ga-Labeled Somatostatin Receptor Ligand

scientific article published on 8 December 2016

Peptide receptor expression in GEP-NET.

scientific article published on 8 August 2007

Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma

scientific article published in June 2014

Peptide receptors as molecular targets for cancer diagnosis and therapy

scientific article

Peptide-based probes for cancer imaging

scientific article published on 16 October 2008

Phosphorylation of sst2 Receptors in Neuroendocrine Tumors after Octreotide Treatment of Patients ⬇️

scientific article published on May 1, 2012

Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist--from mice to men.

scientific article

Preoperative localization of adult nesidioblastosis using ⁶⁸Ga-DOTA-exendin-4-PET/CT.

scientific article

Procholecystokinin as marker of human Ewing sarcomas

scientific article published on August 2004

Radiolabeled Bicyclic Somatostatin-Based Analogs: A Novel Class of Potential Radiotracers for SPECT/PET of Neuroendocrine Tumors ⬇️

scientific article published on October 18, 2010

Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors

scholarly article

Relevance of Somatostatin Receptors and Other Peptide Receptors in Pathology

scientific article

Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity

scientific article

Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity

scientific article published on 12 April 2008

Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice

scientific article published on 22 December 2005

Safety, Biodistribution, and Radiation Dosimetry of (68)Ga-OPS202 ((68)Ga-NODAGA-JR11) in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Phase I Imaging Study

scientific article published on 12 October 2017

Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia

scientific article published on October 2005

Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma

scientific article

Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer 177Lu-AMBA.

scientific article

Somatostatin Receptor Subtype 2A Immunohistochemistry Using a New Monoclonal Antibody Selects Tumors Suitable for In Vivo Somatostatin Receptor Targeting ⬇️

scientific article published on February 1, 2012

Somatostatin and other Peptide receptors as tools for tumor diagnosis and treatment

scientific article published in January 2004

Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan

scientific article published in January 2005

Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides

scientific article published in January 2005

Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR.

scientific article published in January 2005

Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas

scientific article

Somatostatin receptor subtypes sst1, sst2, sst3 and sst5expression in human pituitary, gastroentero-pancreatic and mammary tumors

scientific article published on 4 March 1997

Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog

scientific article

Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments

scientific article published in December 2013

Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors

scientific article published in September 2004

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors

scientific article published on April 2009

Targeted Radiotherapy of Prostate Cancer with a Gastrin-Releasing Peptide Receptor Antagonist Is Effective as Monotherapy and in Combination with Rapamycin ⬇️

scientific article published on March 14, 2013

Targeting CCK receptors in human cancers

scientific article published on January 2007

Targeting GRPR in urological cancers—from basic research to clinical application ⬇️

scientific article published on March 19, 2013

Tetraamine-derived bifunctional chelators for technetium-99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours

scientific article

The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei

scientific article (publication date: 17 May 2002)

The glucose-dependent insulinotropic polypeptide receptor: a novel target for neuroendocrine tumor imaging—first preclinical studies

scientific article

The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist

Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR.

scientific article published on December 2008

Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography

scientific article published in December 2005

Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue

scientific article

[(99m)Tc]Demomedin C, a radioligand based on human gastrin releasing peptide(18-27): synthesis and preclinical evaluation in gastrin releasing peptide receptor-expressing models

scientific article published on 26 September 2012

[111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors

scientific article

[99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging

scientific article published on 29 November 2002

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