List of works - Michael Griffin

A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis

article

A Structural Core Within Apolipoprotein C-II Amyloid Fibrils Identified Using Hydrogen Exchange and Proteolysis

article

A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations

scientific article published in February 2011

A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking

scientific article

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

scientific article

An equilibrium model for linear and closed-loop amyloid fibril formation.

scientific article

Apolipoproteins and amyloid fibril formation in atherosclerosis ⬇️

scientific article published on March 12, 2011

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

scientific article published on 16 November 2012

Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.

scientific article published on 9 August 2016

Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis

scientific article published on 3 June 2015

Characterization of the structure, expression and function of Pinus radiata D. Don arabinogalactan-proteins

scientific article published on 14 June 2007

Charge and Charge-Pair Mutations Alter the Rate of Assembly and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

scientific article published on 02 February 2015

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus.

scientific article published on 17 April 2014

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureus

scientific article published on 17 April 2014

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

scientific article

Cryo-EM structure of an essential Plasmodium vivax invasion complex

scientific article published in Nature

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

scientific article published in Nature Communications

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

scientific article

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

scientific article

Diagnostics for amyloid fibril formation: where to begin?

scientific article

Does domain swapping improve the stability of RNase A?

scientific article published on 3 March 2009

EPO does not promote interaction between the erythropoietin and beta-common receptors

scientific article published in Scientific Reports

Evolution of quaternary structure in a homotetrameric enzyme

scientific article

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

scientific article published on 15 November 2009

Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

scientific article published on 12 June 2015

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

scientific article (publication date: 2013)

Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational noncrystallographic symmetry: a case study involving pyruvate kinase.

scientific article

High-affinity amphipathic modulators of amyloid fibril nucleation and elongation

scientific article published on 23 December 2010

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II.

scientific article published on 21 July 2015

Identification of a second binding site on the TRIM25 B30.2 domain.

scientific article published on 19 December 2017

Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I

scientific article

Insight into the self-association of key enzymes from pathogenic species.

scientific article

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

scientific article published on 23 February 2017

Lipids enhance apolipoprotein C-II-derived amyloidogenic peptide oligomerization but inhibit fibril formation.

scientific article

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

scientific article published in March 2018

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

scientific article published on 31 March 2021

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.

scientific article

N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

scientific article published on 16 May 2020

NBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils.

scientific article

Notch ligand delta-like1: X-ray crystal structure and binding affinity

scientific article

Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.

scientific article published on 22 October 2007

Phospholipids enhance nucleation but not elongation of apolipoprotein C-II amyloid fibrils

scientific article

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1.

scientific article published on 3 August 2016

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

scientific article published on 16 November 2015

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

scientific article published on 09 June 2018

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3

scientific article published on 01 November 2019

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

scientific article published on 01 April 2019

Sedimentation Velocity Analysis of the Size Distribution of Amyloid Oligomers and Fibrils.

scientific article

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

scientific article (publication date: 9 June 2016)

Shear Flow Induced Changes in Apolipoprotein C-II Conformation and Amyloid Fibril Formation

scientific article published on 22 April 2011

Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78

scientific article

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

scientific article published on September 2016

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations.

scientific article published on 17 June 2016

Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase ⬇️

scientific article (publication date: 2012)

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

scientific article

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

scientific article published on 27 October 2017

Structure-function analyses of two plant meso-diaminopimelate decarboxylase isoforms reveal that active-site gating provides stereochemical control

scientific article published on 08 April 2019

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

scientific article published on 24 May 2018

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

scientific article

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

scientific article published on 01 November 2018

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II.

scientific article published on January 2015

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

scientific article published on 14 February 2018

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

scientific article

The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana

scientific article

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

scientific article

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

scientific article published on 05 August 2019

The structure of the extracellular domains of human interleukin 11 α-receptor reveals mechanisms of cytokine engagement

scientific article published on 24 April 2020

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

scientific article

Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase.

scientific article published on 30 November 2017

Visualization of polymorphism in apolipoprotein C-II amyloid fibrils

scientific article published on 30 September 2010

List of works by Michael Griffin

A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis

A Structural Core Within Apolipoprotein C-II Amyloid Fibrils Identified Using Hydrogen Exchange and Proteolysis

A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations

A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

An equilibrium model for linear and closed-loop amyloid fibril formation.

Apolipoproteins and amyloid fibril formation in atherosclerosis ⬇️

Avoiding the oligomeric state: αB-crystallin inhibits fragmentation and induces dissociation of apolipoprotein C-II amyloid fibrils

Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.

Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis

Characterization of the structure, expression and function of Pinus radiata D. Don arabinogalactan-proteins

Charge and Charge-Pair Mutations Alter the Rate of Assembly and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureus

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Diagnostics for amyloid fibril formation: where to begin?

Does domain swapping improve the stability of RNase A?

EPO does not promote interaction between the erythropoietin and beta-common receptors

Evolution of quaternary structure in a homotetrameric enzyme

Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?

Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

From knock-out phenotype to three-dimensional structure of a promising antibiotic target from Streptococcus pneumoniae

Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational noncrystallographic symmetry: a case study involving pyruvate kinase.

High-affinity amphipathic modulators of amyloid fibril nucleation and elongation

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II.

Identification of a second binding site on the TRIM25 B30.2 domain.

Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I

Insight into the self-association of key enzymes from pathogenic species.

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

Lipids enhance apolipoprotein C-II-derived amyloidogenic peptide oligomerization but inhibit fibril formation.

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.

N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

NBD-labeled phospholipid accelerates apolipoprotein C-II amyloid fibril formation but is not incorporated into mature fibrils.

Notch ligand delta-like1: X-ray crystal structure and binding affinity

Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.

Phospholipids enhance nucleation but not elongation of apolipoprotein C-II amyloid fibrils

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1.

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

Sedimentation Velocity Analysis of the Size Distribution of Amyloid Oligomers and Fibrils.

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Shear Flow Induced Changes in Apolipoprotein C-II Conformation and Amyloid Fibril Formation

Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78

Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations.

Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase ⬇️

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

Structure-function analyses of two plant meso-diaminopimelate decarboxylase isoforms reveal that active-site gating provides stereochemical control

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target

Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II.

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

The structure of the extracellular domains of human interleukin 11 α-receptor reveals mechanisms of cytokine engagement

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase.

Visualization of polymorphism in apolipoprotein C-II amyloid fibrils