List of works - Takayoshi Nakano

A Novel Ex Vivo Bone Culture Model for Regulation of Collagen/Apatite Preferential Orientation by Mechanical Loading

scientific article published in 2022

A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement

scientific article published on 11 September 2020

A paradigm shift for bone quality in dentistry: A literature review.

scientific article

Abnormal arrangement of a collagen/apatite extracellular matrix orthogonal to osteoblast alignment is constructed by a nanoscale periodic surface structure.

scientific article published on 30 October 2014

Alignment of Biological Apatite c-Axis Under Functional Loading: A Preliminary Report

scientific article published on 8 August 2016

Alignment of biological apatite crystallites at first molar in human mandible cortical bone

scientific article published on 01 January 2012

Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis

scientific article published on 17 March 2017

Altered material properties are responsible for bone fragility in rats with chronic kidney injury.

scientific article published on 14 July 2015

Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats

scientific article published on 29 September 2020

Biocompatible low Young's modulus achieved by strong crystallographic elastic anisotropy in Ti-15Mo-5Zr-3Al alloy single crystal

scientific article published on 22 May 2012

Biocompatible nanostructured solid adhesives for biological soft tissues.

scientific article published on 5 May 2017

Biological apatite (BAp) crystallographic orientation and texture as a new index for assessing the microstructure and function of bone regenerated by tissue engineering

scientific article published on 14 July 2012

Biomechanical evaluation of regenerating long bone by nanoindentation

scientific article published on 01 March 2011

Biomimetic mineralization using matrix vesicle nanofragments

scientific article published on 11 February 2019

Cell-Based Fabrication of Organic/Inorganic Composite Gel Material.

scientific article

Chondrocyte burst promotes space for mineral expansion

scientific article published on 15 January 2018

Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix

scientific article published on 03 August 2012

Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur

scientific article published on 14 July 2017

Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects.

scientific article

Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin

scientific article

Construction of human induced pluripotent stem cell-derived oriented bone matrix microstructure by using in vitro engineered anisotropic culture model.

scientific article

Continuous cyclic stretch induces osteoblast alignment and formation of anisotropic collagen fiber matrix ⬇️

scientific article published on March 20, 2013

Crystallographic Approach to Regenerated and Pathological Hard Tissues

scientific article published on 15 April 2006

Crystallographic orientation of the c-axis of biological apatite as a new index of the quality of subchondral bone in knee joint osteoarthritis.

scientific article published on 29 March 2016

Degradation behavior of Ca-Mg-Zn intermetallic compounds for use as biodegradable implant materials.

scientific article published on 19 August 2014

Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using recombinant bone morphogenetic protein-2.

scientific article published in May 2013

Design and optimization of the oriented groove on the hip implant surface to promote bone microstructure integrity

scientific article published on 10 November 2012

Development of a root canal treatment model in the rat.

scientific article

Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

scientific article published on 06 February 2019

Development of orthophosphosilicate glass / poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

scientific article published on 27 July 2020

Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer.

scientific article published on 6 January 2017

Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect

scientific article published on 29 July 2018

Dynamic Collision Behavior Between Osteoblasts and Tumor Cells Regulates the Disordered Arrangement of Collagen Fiber/Apatite Crystals in Metastasized Bone ⬇️

scientific article published on 05 November 2018

Early initiation of endochondral ossification of mouse femur cultured in hydrogel with different mechanical stiffness

scientific article published on 13 January 2015

Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces

scientific article published on 01 January 2012

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

scientific article

Effects of mechanical repetitive load on bone quality around implants in rat maxillae.

scientific article published on 15 December 2017

Effects of single or combination therapy of teriparatide and anti-RANKL monoclonal antibody on bone defect regeneration in mice

scientific article

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

scientific article published on 06 July 2010

Evaluation of crystallographic orientation of biological apatite in vertebral cortical bone in ovariectomized cynomolgus monkeys treated with minodronic acid and alendronate.

scientific article published on 3 April 2015

Fabrication of Ti-Alloy Powder/Solid Composite with Uniaxial Anisotropy by Introducing Unidirectional Honeycomb Structure via Electron Beam Powder Bed Fusion

scientific article published on 06 September 2021

Hypermineralization of Hearing‐Related Bones by a Specific Osteoblast Subtype

scientific article published in 2021

Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs

scientific article published on 02 September 2020

In vitro assessment of a calcium-fluoroaluminosilicate glass-based desensitizer for the prevention of root surface demineralization.

scientific article

In vitro reproduction of endochondral ossification using a 3D mesenchymal stem cell construct

scientific article published on 01 October 2012

Influence of Implant Neck Design on Bone Formation Under Mechanical Repetitive Loading: Histomorphometric and Microcomputed Tomographic Studies in Rabbit Tibiae.

scientific article published on 22 January 2016

Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development of single crystalline β-Ti implants.

scientific article published on 15 July 2016

Mesenchymal stromal cells improve the osteogenic capabilities of mineralized agarose gels in a rat full-thickness cranial defect model ⬇️

scientific article published on February 9, 2012

Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses

scientific article published on 19 March 2020

Micro-Architectural Investigation of Teleost Fish Rib Inducing Pliant Mechanical Property

scientific article published on 12 November 2020

Morphology analysis of vertebral trabecular bone under dynamic loading based on multi-scale theory

scientific article published on 05 September 2012

Non-Surgical Model for Alveolar Bone Regeneration by Bone Morphogenetic Protein-2/7 Gene Therapy

scientific article

Novel evaluation method of dentin repair by direct pulp capping using high-resolution micro-computed tomography.

scientific article published on 12 February 2018

ONO-1301 loaded nanocomposite scaffolds modulate cAMP mediated signaling and induce new bone formation in critical sized bone defect

scientific article published on 11 December 2019

Optimally oriented grooves on dental implants improve bone quality around implants under repetitive mechanical loading.

scientific article published on 9 November 2016

Optimization of Cr content of metastable β-type Ti–Cr alloys with changeable Young’s modulus for spinal fixation applications ⬇️

scientific article published on February 15, 2012

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

scientific article published on 28 May 2020

Osteoporosis Changes Collagen/Apatite Orientation and Young's Modulus in Vertebral Cortical Bone of Rat

scientific article published on 26 December 2018

Outstanding compressive creep strength in Cr/Ir-codoped (Mo0.85Nb0.15)Si2 crystals with the unique cross-lamellar microstructure

scientific article published on 21 June 2017

Outstanding in vivo mechanical integrity of additively manufactured spinal cages with a novel “honeycomb tree structure” design via guiding bone matrix orientation

scientific article published on 05 June 2022

Possibility of Mg- and Ca-based intermetallic compounds as new biodegradable implant materials.

scientific article published on 6 June 2013

Preparation of orthophosphate glasses in the MgO-CaO-SiO2-Nb2O5-P2O5 system

scientific article published in January 2017

Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials.

scientific article

Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration

scientific article published on 30 December 2020

Promotion of endodontic lesions in rats by a novel extraradicular biofilm model using obturation materials.

scientific article

Quantitative Evaluation of Osteocyte Morphology and Bone Anisotropic Extracellular Matrix in Rat Femur

scientific article published in 2021

Quantitative regulation of bone-mimetic, oriented collagen/apatite matrix structure depends on the degree of osteoblast alignment on oriented collagen substrates

scientific article published on 25 April 2014

Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects.

scientific article published in June 2010

Role of Osteoclast in Preferential Alignment of Biological Apatite (BAp) in Long Bones

scientific article published on 15 April 2006

Role of Stress Distribution on Healing Process of Preferential Alignment of Biological Apatite in Long Bones

scientific article published on 15 April 2006

Solidification Microstructures of the Ingots Obtained by Arc Melting and Cold Crucible Levitation Melting in TiNbTaZr Medium-Entropy Alloy and TiNbTaZrX (X = V, Mo, W) High-Entropy Alloys

scientific article published on 10 May 2019

Stochastic multi-scale prediction on the apparent elastic moduli of trabecular bone considering uncertainties of biological apatite (BAp) crystallite orientation and image-based modelling.

scientific article published on 14 April 2013

Structural and Qualitative Bone Remodeling Around Repetitive Loaded Implants in Rabbits

scientific article published on 23 March 2015

Structure, dissolution behavior, cytocompatibility, and antibacterial activity of silver-containing calcium phosphate invert glasses.

scientific article

Study on bone quality in the human mandible-Alignment of biological apatite crystallites

scientific article published on 08 October 2018

Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis.

scientific article published on 15 December 2016

The alignment of MC3T3-E1 osteoblasts on steps of slip traces introduced by dislocation motion

scientific article published on 20 July 2012

The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility.

scientific article published on January 2012

Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine.

scientific article

Type-I Angiotensin II Receptor Blockade Reduces Uremia-induced Deterioration of Bone Material Properties

scientific article published on 12 August 2020

UVA-activated riboflavin promotes collagen crosslinking to prevent root caries

scientific article published in Scientific Reports

Unloading-Induced Degradation of the Anisotropic Arrangement of Collagen/Apatite in Rat Femurs.

scientific article published on 22 October 2016

Unusual dynamic precipitation softening induced by dislocation glide in biomedical beta-titanium alloys

scientific article published on 14 August 2017

Use of PIXE/PIGE for sequential Ca and F measurements in root carious model

scientific article published on 18 October 2017

Using HAADF-STEM for atomic-scale evaluation of incorporation of antibacterial Ag atoms in a β-tricalcium phosphate structure

scientific article published on 05 August 2020

Zirconia-hydroxyapatite composite material with micro porous structure

scientific article published on 03 August 2011

List of works by Takayoshi Nakano

A Novel Ex Vivo Bone Culture Model for Regulation of Collagen/Apatite Preferential Orientation by Mechanical Loading

A Novel Role of Interleukin-6 as a Regulatory Factor of Inflammation-Associated Deterioration in Osteoblast Arrangement

A paradigm shift for bone quality in dentistry: A literature review.

Abnormal arrangement of a collagen/apatite extracellular matrix orthogonal to osteoblast alignment is constructed by a nanoscale periodic surface structure.

Alignment of Biological Apatite c-Axis Under Functional Loading: A Preliminary Report

Alignment of biological apatite crystallites at first molar in human mandible cortical bone

Alteration of osteoblast arrangement via direct attack by cancer cells: New insights into bone metastasis

Altered material properties are responsible for bone fragility in rats with chronic kidney injury.

Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats

Biocompatible low Young's modulus achieved by strong crystallographic elastic anisotropy in Ti-15Mo-5Zr-3Al alloy single crystal

Biocompatible nanostructured solid adhesives for biological soft tissues.

Biological apatite (BAp) crystallographic orientation and texture as a new index for assessing the microstructure and function of bone regenerated by tissue engineering

Biomechanical evaluation of regenerating long bone by nanoindentation

Biomimetic mineralization using matrix vesicle nanofragments

Cell-Based Fabrication of Organic/Inorganic Composite Gel Material.

Chondrocyte burst promotes space for mineral expansion

Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix

Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur

Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects.

Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin

Construction of human induced pluripotent stem cell-derived oriented bone matrix microstructure by using in vitro engineered anisotropic culture model.

Continuous cyclic stretch induces osteoblast alignment and formation of anisotropic collagen fiber matrix ⬇️

Crystallographic Approach to Regenerated and Pathological Hard Tissues

Crystallographic orientation of the c-axis of biological apatite as a new index of the quality of subchondral bone in knee joint osteoarthritis.

Degradation behavior of Ca-Mg-Zn intermetallic compounds for use as biodegradable implant materials.

Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using recombinant bone morphogenetic protein-2.

Design and optimization of the oriented groove on the hip implant surface to promote bone microstructure integrity

Development of a root canal treatment model in the rat.

Development of bifunctional oriented bioactive glass/poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation

Development of orthophosphosilicate glass / poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

Disruption of collagen/apatite alignment impairs bone mechanical function in osteoblastic metastasis induced by prostate cancer.

Dual release of growth factor from nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in rat critical sized calvarial defect

Dynamic Collision Behavior Between Osteoblasts and Tumor Cells Regulates the Disordered Arrangement of Collagen Fiber/Apatite Crystals in Metastasized Bone ⬇️

Early initiation of endochondral ossification of mouse femur cultured in hydrogel with different mechanical stiffness

Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

Effects of mechanical repetitive load on bone quality around implants in rat maxillae.

Effects of single or combination therapy of teriparatide and anti-RANKL monoclonal antibody on bone defect regeneration in mice

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Evaluation of crystallographic orientation of biological apatite in vertebral cortical bone in ovariectomized cynomolgus monkeys treated with minodronic acid and alendronate.

Fabrication of Ti-Alloy Powder/Solid Composite with Uniaxial Anisotropy by Introducing Unidirectional Honeycomb Structure via Electron Beam Powder Bed Fusion

Hypermineralization of Hearing‐Related Bones by a Specific Osteoblast Subtype

Impaired bone quality characterized by apatite orientation under stress shielding following fixing of a fracture of the radius with a 3D printed Ti-6Al-4V custom-made bone plate in dogs

In vitro assessment of a calcium-fluoroaluminosilicate glass-based desensitizer for the prevention of root surface demineralization.

In vitro reproduction of endochondral ossification using a 3D mesenchymal stem cell construct

Influence of Implant Neck Design on Bone Formation Under Mechanical Repetitive Loading: Histomorphometric and Microcomputed Tomographic Studies in Rabbit Tibiae.

Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development of single crystalline β-Ti implants.

Mesenchymal stromal cells improve the osteogenic capabilities of mineralized agarose gels in a rat full-thickness cranial defect model ⬇️

Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses

Micro-Architectural Investigation of Teleost Fish Rib Inducing Pliant Mechanical Property

Morphology analysis of vertebral trabecular bone under dynamic loading based on multi-scale theory

Non-Surgical Model for Alveolar Bone Regeneration by Bone Morphogenetic Protein-2/7 Gene Therapy

Novel evaluation method of dentin repair by direct pulp capping using high-resolution micro-computed tomography.

ONO-1301 loaded nanocomposite scaffolds modulate cAMP mediated signaling and induce new bone formation in critical sized bone defect

Optimally oriented grooves on dental implants improve bone quality around implants under repetitive mechanical loading.

Optimization of Cr content of metastable β-type Ti–Cr alloys with changeable Young’s modulus for spinal fixation applications ⬇️

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

Osteoporosis Changes Collagen/Apatite Orientation and Young's Modulus in Vertebral Cortical Bone of Rat

Outstanding compressive creep strength in Cr/Ir-codoped (Mo0.85Nb0.15)Si2 crystals with the unique cross-lamellar microstructure

Outstanding in vivo mechanical integrity of additively manufactured spinal cages with a novel “honeycomb tree structure” design via guiding bone matrix orientation

Possibility of Mg- and Ca-based intermetallic compounds as new biodegradable implant materials.

Preparation of orthophosphate glasses in the MgO-CaO-SiO2-Nb2O5-P2O5 system

Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials.

Promoting Effect of Basic Fibroblast Growth Factor in Synovial Mesenchymal Stem Cell-Based Cartilage Regeneration

Promotion of endodontic lesions in rats by a novel extraradicular biofilm model using obturation materials.

Quantitative Evaluation of Osteocyte Morphology and Bone Anisotropic Extracellular Matrix in Rat Femur

Quantitative regulation of bone-mimetic, oriented collagen/apatite matrix structure depends on the degree of osteoblast alignment on oriented collagen substrates

Regenerative behavior of biomineral/agarose composite gels as bone grafting materials in rat cranial defects.

Role of Osteoclast in Preferential Alignment of Biological Apatite (BAp) in Long Bones

Role of Stress Distribution on Healing Process of Preferential Alignment of Biological Apatite in Long Bones

Solidification Microstructures of the Ingots Obtained by Arc Melting and Cold Crucible Levitation Melting in TiNbTaZr Medium-Entropy Alloy and TiNbTaZrX (X = V, Mo, W) High-Entropy Alloys

Stochastic multi-scale prediction on the apparent elastic moduli of trabecular bone considering uncertainties of biological apatite (BAp) crystallite orientation and image-based modelling.

Structural and Qualitative Bone Remodeling Around Repetitive Loaded Implants in Rabbits

Structure, dissolution behavior, cytocompatibility, and antibacterial activity of silver-containing calcium phosphate invert glasses.

Study on bone quality in the human mandible-Alignment of biological apatite crystallites

Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis.

The alignment of MC3T3-E1 osteoblasts on steps of slip traces introduced by dislocation motion

The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility.

Trabecular health of vertebrae based on anisotropy in trabecular architecture and collagen/apatite micro-arrangement after implantation of intervertebral fusion cages in the sheep spine.