List of works - Rekha G Panchal

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

scientific article

A high content imaging assay for identification of Botulinum neurotoxin inhibitors

scientific article

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

scientific article

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

scientific article

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

scientific article published on 07 April 2007

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection

scientific article

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns

scientific article

Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer

scientific article published on 01 October 1992

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

scientific article

Analysis of Ebola virus and VLP release using an immunocapture assay.

scientific article

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

scientific article published on 8 August 2005

Anti-Ebola Activity of Diazachrysene Small Molecules.

scientific article published on 4 May 2015

Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens

scientific article

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

scientific article published on 16 April 2016

Bacterial genome engineering and synthetic biology: combating pathogens

scientific article

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

scientific article

Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics

scientific article published in Scientific Reports

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

scientific article published on 14 November 2012

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

scientific article published on 6 November 2015

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

scientific article published on 07 February 2019

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

scientific article published on January 2005

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

scientific article

Development of high-content imaging assays for lethal viral pathogens.

scientific article published on 16 July 2010

Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini.

scientific article published in September 1994

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

scientific article published on 11 May 2015

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

scientific article

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

scientific article published on 26 September 2014

Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes.

scientific article published in June 2005

Gene transfer: manipulating and monitoring function in cells and tissues.

scientific article

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

scientific article

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

scientific article

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

scientific article

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

scientific article

Identification of small molecule inhibitors of anthrax lethal factor

scientific article

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

scientific article

Induced IL-10 splice altering approach to antiviral drug discovery.

scientific article published on 21 March 2014

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection

scientific article

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

scientific article

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

scientific article

Molecular mechanisms of filovirus cellular trafficking.

scientific article

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

scientific article published in October 2003

Novel therapeutic strategies to selectively kill cancer cells.

scientific article published on February 1998

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

scientific article published on 15 May 2006

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

scientific article

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

scientific article

Pore formation is not associated with macroscopic redistribution of P2X7 receptors.

scientific article

Pore-forming proteins and their application in biotechnology.

scientific article

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

scientific article published on 25 October 2013

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

scientific article published in March 2007

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

scientific article

Rational design of small molecules as vaccine adjuvants.

scientific article published on November 2014

Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.

scientific article published in June 1994

Robust biofilm assay for quantification and high throughput screening applications

scientific article published on 28 February 2019

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

scientific article published on 18 March 2015

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

scientific article published on 31 October 2018

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)

scientific article published on August 2008

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

scientific article

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

scientific article published on 18 January 2019

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

scientific article

Tumor protease-activated, pore-forming toxins from a combinatorial library.

scientific article

List of works by Rekha G Panchal

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

A high content imaging assay for identification of Botulinum neurotoxin inhibitors

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns

Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

Analysis of Ebola virus and VLP release using an immunocapture assay.

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

Anti-Ebola Activity of Diazachrysene Small Molecules.

Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Bacterial genome engineering and synthetic biology: combating pathogens

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

Development of high-content imaging assays for lethal viral pathogens.

Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini.

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes.

Gene transfer: manipulating and monitoring function in cells and tissues.

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

Identification of small molecule inhibitors of anthrax lethal factor

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

Induced IL-10 splice altering approach to antiviral drug discovery.

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

Molecular mechanisms of filovirus cellular trafficking.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Novel therapeutic strategies to selectively kill cancer cells.

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Pore formation is not associated with macroscopic redistribution of P2X7 receptors.

Pore-forming proteins and their application in biotechnology.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Rational design of small molecules as vaccine adjuvants.

Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.

Robust biofilm assay for quantification and high throughput screening applications

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

Tumor protease-activated, pore-forming toxins from a combinatorial library.