List of works - Axel Methner

A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.

scientific article

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.

scientific article published on 25 August 2015

An emboligenic pulmonary abscess leading to ischemic stroke and secondary brain abscess.

scientific article

Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress.

scientific article published on 31 March 2016

BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival

scientific article

Bax inhibitor-1 deficiency leads to obesity by increasing Ca2+-dependent insulin secretion

scientific article published on 11 May 2020

Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.

scientific article

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.

scientific article published on 28 September 2011

Correction: Promoting Myelination in an Mouse Model of the Peripheral Nervous System: The Effect of Wine Ingredients

article by Mark Stettner et al published 20 September 2013 in PLOS ONE

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography

scientific article published on 02 March 2012

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase

scientific article published on January 2017

Effects of dimethyl fumarate on neuroprotection and immunomodulation.

scientific article

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.

scientific article

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.

scientific article published on 26 January 2013

Free caspase activity in CSF of patients with dementia.

scientific article published on 8 May 2009

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

scientific article published on 03 June 2022

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy.

scientific article published on 8 October 2013

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

Guillain-Barré syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes

scientific article published on 19 July 2011

Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione.

scientific article published on November 2006

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

scientific article

Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.

scientific article published on 15 November 2013

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

scientific article published on 04 September 2018

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress

scientific article published on April 2014

Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS

scientific article

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.

scientific article

POEMS-Syndrom

scientific article published on 01 October 2011

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.

scientific article

Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery

scientific article published on 27 March 2020

Regulation of xCT expression and system x (c) (-) function in neuronal cells.

scientific article

Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia.

scientific article published on 09 April 2014

Retinal Neurodegeneration in Wilson’s Disease Revealed by Spectral Domain Optical Coherence Tomography ⬇️

scientific article published on November 16, 2012

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.

scientific article published on 30 August 2011

Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.

scientific article published on 17 October 2012

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex

scientific article

TOX3 regulates neural progenitor identity

scientific article published on 11 April 2016

Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease

scientific article

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

scientific article

The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress

scientific article published on 21 October 2019

The ancient cell death suppressor BAX inhibitor-1 ⬇️

scientific article published on June 12, 2011

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. ⬇️

scientific article

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress ⬇️

scientific article published on January 24, 2013

The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

scientific article

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

scientific article published on 17 May 2017

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

scientific article

Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery

scientific article published on 23 September 2020

List of works by Axel Methner

A case of relapsing-remitting neuroborreliosis? Challenges in the differential diagnosis of recurrent myelitis.

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.

An emboligenic pulmonary abscess leading to ischemic stroke and secondary brain abscess.

Androgen-inducible gene 1 increases the ER Ca(2+) content and cell death susceptibility against oxidative stress.

BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival

Bax inhibitor-1 deficiency leads to obesity by increasing Ca2+-dependent insulin secretion

Bax inhibitor-1 is likely a pH-sensitive calcium leak channel, not a H+/Ca2+ exchanger.

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.

Correction: Promoting Myelination in an Mouse Model of the Peripheral Nervous System: The Effect of Wine Ingredients

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase

Effects of dimethyl fumarate on neuroprotection and immunomodulation.

Expression of genes encoding the calcium signalosome in cellular and transgenic models of Huntington's disease.

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.

Free caspase activity in CSF of patients with dementia.

GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton

Genetic shift of env V3 loop viral sequences in patients with HIV-associated neurocognitive disorder during antiretroviral therapy.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Guillain-Barré syndrome variant with prominent facial diplegia, limb paresthesia, and brisk reflexes

Induction of Bcl-2 by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein (GABARAP): biophysical characterization and functional implications.

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress

Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.

POEMS-Syndrom

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.

Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery

Regulation of xCT expression and system x (c) (-) function in neuronal cells.

Regulators of mitochondrial Ca(2+) homeostasis in cerebral ischemia.

Retinal Neurodegeneration in Wilson’s Disease Revealed by Spectral Domain Optical Coherence Tomography ⬇️

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.

Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress.

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex

TOX3 regulates neural progenitor identity

Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease

The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress

The ancient cell death suppressor BAX inhibitor-1 ⬇️

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. ⬇️

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress ⬇️

The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery