List of works - William C. Sessa

Nitric oxide synthases: regulation and function

scientific article (publication date: April 2012)

Evolving functions of endothelial cells in inflammation

scientific article published on October 2007

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

scientific journal article

Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells

scientific article published on 22 March 2007

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis

scholarly article

eNOS at a glance

scientific article published on May 2004

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

scientific article published on August 2006

MicroRNAs as novel regulators of angiogenesis

scientific article published on February 2009

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels

scientific article published on May 2006

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

scientific journal article

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve

scientific article

Caveolin regulation of endothelial function

scientific article published on December 2003

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function

scientific article

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

scientific article

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

scientific article published on 12 November 2002

Regulation of survivin function by Hsp90

scientific article

Caveolae and caveolins in the cardiovascular system

scientific article

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice

scientific article

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

scientific article published on 18 February 2003

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking

scholarly article

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

scientific article published on 2 September 2003

A new role for Nogo as a regulator of vascular remodeling

scientific article

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase

scientific article

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice

scientific article published on 01 July 2003

Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides

scientific article

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

scientific article published on June 2011

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells

scientific journal article

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

scientific article

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

scientific article

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function

scientific article

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

scientific article

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth

scientific article published in March 2007

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

scientific article

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

scientific article published on July 2007

Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo

scientific article published on 18 January 2008

miRNAs as modulators of angiogenesis

scientific article published on February 2013

Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions

scientific article published on March 2007

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

scientific article published on 21 July 2009

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.

scientific article published on 17 September 2009

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

scientific article published on 01 June 2005

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion

scientific article

Inhibitor of apoptosis protein survivin regulates vascular injury

scientific article published on 12 August 2002

Endothelial nitric oxide synthase: the Cinderella of inflammation?

scientific article

Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis

scientific article published on November 2006

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release

scientific article

Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis.

scientific article published on July 2009

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

scientific article

Perivascular nitric oxide gradients normalize tumor vasculature

scientific article published on 17 February 2008

Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells

scholarly article

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function

scientific journal article

List of works by William C. Sessa

Nitric oxide synthases: regulation and function

Evolving functions of endothelial cells in inflammation

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis

eNOS at a glance

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

MicroRNAs as novel regulators of angiogenesis

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve

Caveolin regulation of endothelial function

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

Regulation of survivin function by Hsp90

Caveolae and caveolins in the cardiovascular system

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

A new role for Nogo as a regulator of vascular remodeling

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase

Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice

Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo

miRNAs as modulators of angiogenesis

Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion

Inhibitor of apoptosis protein survivin regulates vascular injury

Endothelial nitric oxide synthase: the Cinderella of inflammation?

Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis

Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release

Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis.

AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice

Perivascular nitric oxide gradients normalize tumor vasculature

Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function