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List of works by Ruggero De Maria

"Triple positive" early breast cancer: an observational multicenter retrospective analysis of outcome.

scientific article published on 18 February 2016

(1) H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness.

scientific article published on 8 January 2015

1H NMR detects different metabolic profiles in glioblastoma stem-like cells.

scientific article published on 21 October 2013

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.

scientific article published on 28 April 2015

A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave?

scientific article published on 11 June 2020

A multicenter REtrospective observational study of first-line treatment with PERtuzumab, trastuzumab and taxanes for advanced HER2 positive breast cancer patients. RePer Study

scientific article

A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors

scientific article published on 23 July 2019

A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

scientific article published on 22 August 2019

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

scientific article published on 08 January 2020

A predictive signature for therapy assignment and risk assessment in prostate cancer.

scientific article

A retrospective multicentric observational study of trastuzumab emtansine in HER2 positive metastatic breast cancer: a real-world experience

scientific article published on 25 May 2017

Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death.

scientific article

Abstract 2484: Non-canonical Hedgehog/Gli1 signaling drives lung adenocarcinoma stem cells survival and its targeting inhibits CSC-derived tumors

Abstract 3312: Protein activation pathway analysis of glioblastoma stem cells reveals potential novel biomarkers

Abstract 803: A vertical combination strategy hitting multiple steps along the MAPK cascade: Molecular mechanisms of action and putative genetic determinants of synergism

Abstract 883: Cell-based selection of RNA-aptamers to specifically target glioblastoma cancer stem cells

Accreditation for excellence of cancer research institutes: recommendations from the Italian Network of Comprehensive Cancer Centers

scientific article

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells ⬇️

scientific article published on March 16, 1998

Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells.

scientific article

Advances towards the design and development of personalized non-small-cell lung cancer drug therapy.

scientific article published on 03 October 2013

Alleanza Contro il Cancro: the accreditation system of the Excellence Network of Italian Cancer Centers in the precision medicine era.

scientific article published on 30 December 2015

Alliance Against Cancer, the network of Italian cancer centers bridging research and care

scientific article

Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells

scientific article published on 3 June 2015

Analysis of T‐Lymphocyte Subsets After Phytohemagglutinin Stimulation in Normal and Type 1 Diabetic Mothers and Their Infants ⬇️

scientific article published on 01 September 1992

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression. ⬇️

scientific article published on 14 August 2017

Analysis of the hippo transducers TAZ and YAP in cervical cancer and its microenvironment.

scientific article published on 28 March 2016

Androgen receptor and antiandrogen therapy in male breast cancer ⬇️

scientific article published on 11 August 2015

Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.

scientific article

Antiandrogen therapy in metastatic male breast cancer: results from an updated analysis in an expanded case series.

scientific article published on 20 September 2014

Antitumor activity of bortezomib alone and in combination with TRAIL in human acute myeloid leukemia.

scientific article published on 21 August 2008

Apoptosis in normal and cancer stem cells.

scientific article

Approaching the increasing complexity of non-small cell lung cancer taxonomy

scientific article published on January 2014

Aromatase inhibitors for metastatic male breast cancer: molecular, endocrine, and clinical considerations.

scientific article published on 13 August 2014

Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer ⬇️

scientific article

Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells

scientific article published on February 2006

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

scientific article published on 7 September 2012

Biological and clinical implications of cancer stem cells in primary brain tumors

scientific article published on 25 January 2013

Blocking the APRIL circuit enhances acute myeloid leukemia cell chemosensitivity

scientific article published on 06 October 2008

Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer.

scientific article

CD147 Promotes Cell Small Extracellular Vesicles Release during Colon Cancer Stem Cells Differentiation and Triggers Cellular Changes in Recipient Cells

scientific article published on 21 January 2020

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.

scientific article published in March 2014

CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

scientific article published on July 2004

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

scientific article

Cancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance.

scientific article

Cancer Stem Cells and Chemosensitivity ⬇️

scientific article published on May 27, 2011

Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme.

scientific article

Cancer stem cell definitions and terminology: the devil is in the details

scientific article published on 11 October 2012

Cancer stem cells as a potential therapeutic target in thyroid carcinoma

scientific article published on 02 August 2016

Cancer stem cells: are they responsible for treatment failure?

scientific article

Cancer stem cells: at the forefront of personalized medicine and immunotherapy

scientific article

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

scientific article published on 30 March 2019

Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to rapamycin.

scientific article published in July 2013

Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor

scientific article

Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer

scientific article published on 04 September 2018

Colon cancer stem cells

scientific article published on 02 September 2009

Colorectal cancer stem cells: from the crypt to the clinic

scientific article

Colorectal cancer: towards new challenges and concepts of preventive healthcare

scientific article

Conditionally reprogrammed cells (CRC) methodology does not allow the in vitro expansion of patient-derived primary and metastatic lung cancer cells

scientific article published on 17 January 2018

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

scientific article published on 02 February 2021

DNA Damage and Repair Biomarkers in Cervical Cancer Patients Treated with Neoadjuvant Chemotherapy: An Exploratory Analysis

scientific article

DNA Damage in Stem Cells

scientific article published on May 2017

DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

scientific article published on 24 February 2017

DNA damage repair pathways in cancer stem cells

scientific article

Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer

scientific article published on 22 July 2018

Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells

scientific article published on 9 June 2017

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells

scientific article published on 12 December 2012

Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting

scientific article published on 07 August 2019

Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies.

scientific article published on 27 March 2012

Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration.

scientific article published on 27 October 2009

Dual promoter usage as regulatory mechanism of let-7c expression in leukemic and solid tumors.

scientific article published on 17 March 2014

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.

scientific article published on 19 August 2016

EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential

scientific article

Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51

scientific article published on 25 February 2022

Efficacy of chemotherapy in metastatic male breast cancer patients: a retrospective study

scientific article

Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes

scientific article published on 01 August 2020

Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis.

scientific article

Erratum: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

scientific article published in Nature

Erythropoietin Activates Cell Survival Pathways in Breast Cancer Stem-like Cells to Protect Them from Chemotherapy

scientific article published on 05 September 2013

Establishing tumor cell lines from aggressive telomerase-positive chordomas of the skull base. Technical note.

scientific article published in September 2006

Establishment of patient-derived renal cell carcinoma (RCC) models based on orthotopic xenografts (PDX) and cancer stem cell (CSC) isolation to provide prognostic and predictive information

Expression of EGFRvIII in glioblastoma: prognostic significance revisited

scientific article published on December 2011

Expression of phosphorylated Hippo pathway kinases (MST1/2 and LATS1/2) in HER2-positive and triple-negative breast cancer patients treated with neoadjuvant therapy.

scientific article published on 7 April 2017

Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy

scientific article published on 5 February 2018

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis.

scientific article

Fas–FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity ⬇️

scientific article published on March 1, 1998

Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL

scientific article

Functional role of microRNAs in prostate cancer and therapeutic opportunities

scientific article published on January 2013

GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer.

scientific article published on 20 May 2017

Gene expression analysis of PTEN positive glioblastoma stem cells identifies DUB3 and Wee1 modulation in a cell differentiation model

scientific article

HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes ⬇️

scientific article published on 07 October 2016

HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome.

scientific article

Hippo pathway and breast cancer stem cells

scientific article published on 18 December 2015

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells

scientific article published on 08 February 2016

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

scientific article

How to Assess Drug Resistance in Cancer Stem Cells

scientific article published in January 2018

IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins

scientific article published on May 2004

Identification and expansion of human colon-cancer-initiating cells

scientific article (publication date: 4 January 2007)

Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real-world evidence

scientific article published on 15 January 2020

Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.

scientific article published on 29 December 2005

Increased phospho-mTOR expression in megakaryocytic cells derived from CD34+ progenitors of essential thrombocythaemia and myelofibrosis patients.

scientific article

Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord

scientific article published on 01 July 2006

Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction

scientific article published in December 2005

Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma

scientific article published on 05 June 2017

International Accreditation of Cancer Centres of Italian Network of Alleanza contro il Cancro: introductory remarks.

scientific article published on 30 December 2015

Knockdown of Ubiquitin Ligases in Glioblastoma Cancer Stem Cells Leads to Cell Death and Differentiation ⬇️

scientific article published on September 28, 2011

Low-intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial-to-mesenchymal transition of colorectal cancer cells

scientific article published on 22 January 2020

MUC1 oncoprotein promotes refractoriness to chemotherapy in thyroid cancer cells

scientific article published on June 2007

Measuring Extracellular Vesicles by Conventional Flow Cytometry: Dream or Reality?

scientific article published on 29 August 2020

Mek inhibition results in marked antitumor activity against metastatic melanoma patient-derived melanospheres and in melanosphere-generated xenografts

scientific article

Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members.

scientific article published on 23 March 2018

MicroRNA as new tools for prostate cancer risk assessment and therapeutic intervention: results from clinical data set and patients' samples

scientific article

MicroRNAs and prostate cancer

scientific article published on 29 January 2010

MicroRNAs and prostate cancer: from preclinical research to translational oncology.

scientific article published on May 2012

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multicohort and cross-platform validation of a prognostic Wnt signature in colorectal cancer

scientific article published on 01 December 2020

Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis

scientific article

Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma

scientific article published on 16 July 2019

NF-κB localization in multiple myeloma plasma cells and mesenchymal cells.

scientific article published on 31 July 2010

New models for cancer research: human cancer stem cell xenografts.

scientific article published on 17 June 2010

Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus ⬇️

scientific article published on October 20, 1997

Not So Lonely at the Top for Cancer Stem Cells ⬇️

scientific article published on October 4, 2011

Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis.

scientific article

Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells.

scientific article published on 16 August 2010

Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases

scientific article published on 27 February 2019

PTEN Tumor-Suppressor: The Dam of Stemness in Cancer

scientific article published on 30 July 2019

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

scientific article published on 21 February 2017

Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity.

scientific article

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: A real-world experience

scientific article published on 10 December 2018

Pluripotency and differentiation in embryos and stem cells.

scientific article published in January 2008

Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis.

scientific article published on 22 April 2004

Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

scientific article published on 17 October 2015

Presurgical window of opportunity trial design as a platform for testing anticancer drugs: Pros, cons and a focus on breast cancer

scientific article published on 21 August 2016

Prevention of chemotherapy-induced anemia and thrombocytopenia by constant administration of stem cell factor

scientific article

Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma

scientific article published on 13 April 2011

Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.

scientific article

Proteasome inhibitors synergize with tumor necrosis factor-related apoptosis-induced ligand to induce anaplastic thyroid carcinoma cell death

scientific article published on 27 February 2007

Protein drug target activation homogeneity in the face of intra-tumor heterogeneity: implications for precision medicine

scientific article

Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations

scientific article

Pyrvinium pamoate induces death of triple-negative breast cancer stem-like cells and reduces metastases through effects on lipid anabolism

scientific article published on 23 July 2020

Quantum dots for biomedical applications

scientific article

Renal cancer: new models and approach for personalizing therapy

scientific article published on 05 September 2018

Replication stress in colorectal cancer stem cells

scientific article published on 20 May 2017

Replication stress response in cancer stem cells as a target for chemotherapy

scientific article published on 03 August 2018

Role of autophagy in the maintenance and function of cancer stem cells

scientific article

Role of gonadotropin-releasing hormone analogues in metastatic male breast cancer: results from a pooled analysis ⬇️

scientific article published on 17 May 2015

Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism

scientific article

Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection

scientific article published on 02 December 2020

Sphere-forming cell subsets with cancer stem cell properties in human musculoskeletal sarcomas

scientific article published on May 2013

Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins

scientific article published on 13 March 2003

Suppressor of cytokine signaling 3 sensitizes anaplastic thyroid cancer to standard chemotherapy.

scientific article published on 28 July 2009

Systems analysis of the NCI-60 cancer cell lines by alignment of protein pathway activation modules with "-OMIC" data fields and therapeutic response signatures

scientific article

THE MIR-15A/MIR-16-1 CLUSTER CONTROLS PROSTATE CANCER PROGRESSION CONTROL BY TARGETING OF MULTIPLE ONCOGENIC ACTIVITIES

TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner.

scientific article

Targeting apoptosis pathways in cancer stem cells

scientific article published on 10 February 2011

Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant

scientific article published on 07 October 2019

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy.

scientific article

The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications.

scientific article published on 02 July 2015

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer ⬇️

scientific article published on 27 May 2016

The Regina Elena National Cancer Institute process of accreditation according to the standards of the Organisation of European Cancer Institutes

scientific article published on 30 December 2015

The clinical significance of PD-L1 in advanced gastric cancer is dependent on ARID1A mutations and ATM expression

scientific article published on 24 April 2018

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response.

scientific article

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice

scientific article

The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

scientific article

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

scientific article

The secretion and maturation of prosaposin and procathepsin D are blocked in embryonic neural progenitor cells.

scientific article

The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation

scientific article

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

scientific article published on 09 July 2018

Therapeutic targeting of cancer stem cells

scientific article published on 17 June 2011

Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells

scientific article published on 21 June 2010

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10

scientific article published on 01 October 2003

Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy

scientific article published on 2 April 2016

Transferrin receptor 2 is frequently and highly expressed in glioblastomas

scientific article

Translating basic research in cancer patient care

scientific article published on January 1, 2011

Tumorigenic and metastatic activity of human thyroid cancer stem cells

scientific article published on 19 October 2010

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

scientific article

Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening

scientific article published on 21 October 2020

Two-Step Co-Immunoprecipitation (TIP)

scientific article published on 30 October 2018

Two-Step Co-Immunoprecipitation (TIP) Enables Efficient and Highly Selective Isolation of Native Protein-Complexes

scientific article published on 7 December 2017

Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas ⬇️

scientific article published on November 23, 2012

Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications.

scientific article

Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

scientific article published on 19 March 2019

miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2

scientific article published on 31 March 2020

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal

scientific article published on 30 September 2015

miR-15/miR-16 loss, miR-21 upregulation, or deregulation of their target genes predicts poor prognosis in prostate cancer patients

scientific article published on 10 December 2015

miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.

scientific article published on 19 January 2018

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