List of works - Bela Novak

A Dynamical Framework for the All-or-None G1/S Transition.

scientific article published on 27 January 2016

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

scientific article published on 22 August 2016

A Single Light-Responsive Sizer Can Control Multiple-Fission Cycles in Chlamydomonas

scientific article published on 09 January 2020

A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells.

scientific article published on 20 February 2018

A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana

scientific article

A model for restriction point control of the mammalian cell cycle.

scientific article published in October 2004

A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches

scientific article

A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.

scientific article

APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity

scientific article published on 10 May 2017

Absolute quantification of cohesin, CTCF and their regulators in human cells

scientific article published on 17 June 2019

Analysis of a generic model of eukaryotic cell-cycle regulation

scientific article

Antagonism and bistability in protein interaction networks.

scientific article

Bistability, oscillations, and traveling waves in frog egg extracts

scientific article

CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast.

scientific article

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization

scientific article published on 23 January 2019

Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches.

scientific article published on November 2011

Cell cycle control by a minimal Cdk network.

scientific article

Cell cycle: who turns the crank?

scientific article published in March 2011

Cell-cycle transitions: a common role for stoichiometric inhibitors.

scientific article published on 20 September 2017

Control of cell growth, division and death: information processing in living cells

scientific article

Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1.

scientific article published on 30 November 2009

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

scientific article published on 30 April 2020

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.

scientific article

Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible

scientific article published on 27 February 2014

Different effects of redundant feedback loops on a bistable switch.

scientific article published in December 2010

Dilution and titration of cell-cycle regulators may control cell size in budding yeast

article

Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

scientific article

Functional motifs in biochemical reaction networks.

scientific article published on January 2010

Genome Stability during Cell Proliferation: A Systems Analysis of the Molecular Mechanisms Controlling Progression through the Eukaryotic Cell Cycle

scientific article published on 22 February 2018

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.

scientific article published on 23 April 2015

Interlinked bistable mechanisms generate robust mitotic transitions.

scientific article

Interplay of transcriptional and proteolytic regulation in driving robust cell cycle progression

scientific article published on 11 January 2012

Irreversibility of mitotic exit is the consequence of systems-level feedback.

scientific article published on 22 April 2009

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.

scientific article published on 9 March 2015

Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.

scientific article

Mathematical model of the cell division cycle of fission yeast.

scientific article

Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions ⬇️

scientific article published on May 5, 1998

Mathematical model of the morphogenesis checkpoint in budding yeast.

scientific article

Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.

scientific article

Microtubules offset growth site from the cell centre in fission yeast

scientific article published on 01 July 2007

Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates.

scientific article published on 19 March 2013

Mitotic kinase oscillation governs the latching of cell cycle switches

scientific article published in 2022

Model scenarios for switch-like mitotic transitions.

scientific article published on 12 February 2015

Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25Delta mutant cells

scientific article published in July 2000

Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

scientific article

Molecular mechanisms creating bistable switches at cell cycle transitions.

scientific article published on 13 March 2013

Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches

scientific article

Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway

scientific article published on 12 January 2016

Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico.

scientific article

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit

scientific article

Phosphorylation network dynamics in the control of cell cycle transitions.

scientific article

Pom1 is not the size ruler.

scientific article published on 15 October 2013

Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback

scientific article

Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions.

scientific article published in November 2011

Robust mitotic entry is ensured by a latching switch

scientific article published on 26 July 2013

Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts.

scientific article published on 02 December 2013

Steady states and oscillations in the p53/Mdm2 network.

scientific article

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

scientific article published on December 2011

System-level feedbacks control cell cycle progression.

scientific article published on December 2009

System-level feedbacks make the anaphase switch irreversible

scientific article

Systems-level feedback regulation of cell cycle transitions in Ostreococcus tauri.

scientific article published on 19 February 2018

Temporal organization of the cell cycle

scientific article published on September 2008

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation

scientific article published on 10 October 2013

The cell cycle

scientific article published on 01 December 2011

The dynamics of cell cycle regulation.

scientific article

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles ⬇️

scientific article published on March 19, 2013

Time scale and dimension analysis of a budding yeast cell cycle model

scientific article

Two Bistable Switches Govern M Phase Entry.

scientific article published on 15 November 2016

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

scientific article published on 15 November 2018

microRNA as a potential vector for the propagation of robustness in protein expression and oscillatory dynamics within a ceRNA network

scientific article

List of works by Bela Novak

A Dynamical Framework for the All-or-None G1/S Transition.

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

A Single Light-Responsive Sizer Can Control Multiple-Fission Cycles in Chlamydomonas

A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells.

A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana

A model for restriction point control of the mammalian cell cycle.

A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches

A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.

APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity

Absolute quantification of cohesin, CTCF and their regulators in human cells

Analysis of a generic model of eukaryotic cell-cycle regulation

Antagonism and bistability in protein interaction networks.

Bistability, oscillations, and traveling waves in frog egg extracts

CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast.

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization

Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches.

Cell cycle control by a minimal Cdk network.

Cell cycle: who turns the crank?

Cell-cycle transitions: a common role for stoichiometric inhibitors.

Control of cell growth, division and death: information processing in living cells

Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1.

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression.

Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible

Different effects of redundant feedback loops on a bistable switch.

Dilution and titration of cell-cycle regulators may control cell size in budding yeast

Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

Functional motifs in biochemical reaction networks.

Genome Stability during Cell Proliferation: A Systems Analysis of the Molecular Mechanisms Controlling Progression through the Eukaryotic Cell Cycle

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.

Interlinked bistable mechanisms generate robust mitotic transitions.

Interplay of transcriptional and proteolytic regulation in driving robust cell cycle progression

Irreversibility of mitotic exit is the consequence of systems-level feedback.

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.

Mathematical model for growth regulation of fission yeast Schizosaccharomyces pombe.

Mathematical model of the cell division cycle of fission yeast.

Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions ⬇️

Mathematical model of the morphogenesis checkpoint in budding yeast.

Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.

Microtubules offset growth site from the cell centre in fission yeast

Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates.

Mitotic kinase oscillation governs the latching of cell cycle switches

Model scenarios for switch-like mitotic transitions.

Modeling the fission yeast cell cycle: quantized cycle times in wee1- cdc25Delta mutant cells

Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

Molecular mechanisms creating bistable switches at cell cycle transitions.

Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches

Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway

Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico.

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit

Phosphorylation network dynamics in the control of cell cycle transitions.

Pom1 is not the size ruler.

Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback

Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions.

Robust mitotic entry is ensured by a latching switch

Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts.

Steady states and oscillations in the p53/Mdm2 network.

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

System-level feedbacks control cell cycle progression.

System-level feedbacks make the anaphase switch irreversible

Systems-level feedback regulation of cell cycle transitions in Ostreococcus tauri.

Temporal organization of the cell cycle

The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation

The cell cycle

The dynamics of cell cycle regulation.

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles ⬇️

Time scale and dimension analysis of a budding yeast cell cycle model

Two Bistable Switches Govern M Phase Entry.

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

microRNA as a potential vector for the propagation of robustness in protein expression and oscillatory dynamics within a ceRNA network