List of works - Mhamed Grati

A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss

scientific article published on 02 June 2018

A familial case of Keratitis-Ichthyosis-Deafness (KID) syndrome with the GJB2 mutation G45E

scientific article published on 04 October 2007

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation

scientific article

A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness

scientific article

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60

scientific article

Association of PRPS1 Mutations with Disease Phenotypes

scientific article

CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.

scientific article published on 10 December 2013

CRISPR: a versatile tool for both forward and reverse genetics research.

scientific article published on 7 July 2016

Characterization of ATPase Activity of P2RX2 Cation Channel

scientific article

Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.

scientific article published on 14 August 2017

Current concepts in the pathogenesis and treatment of chronic suppurative otitis media.

scientific article published on 5 August 2015

DFNB9 and DFNB12.

scientific article

Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice

scientific article published on 21 September 2011

Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family

scientific article

FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing.

scientific article

Genetic analysis of Tunisian families with Usher syndrome type 1: toward improving early molecular diagnosis

scientific article published on 19 July 2016

Immune responses in the mammalian inner ear and their implications for AAV-mediated inner ear gene therapy

scientific article published in 2023

Immunity genes and susceptibility to otitis media: a comprehensive review

scientific article published on 31 October 2014

In vitro interaction of Pseudomonas aeruginosa with human middle ear epithelial cells

scientific article

Indispensable Role of Ion Channels and Transporters in the Auditory System.

scientific article

Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.

scientific article

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions.

scientific article published on 17 May 2016

MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform

scientific article published on 3 February 2016

Methylation Status and Presbycusis Risk in Elderly Women

scientific article published on 07 August 2018

Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.

scientific article

Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells

scientific journal article

Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

scientific article

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

scientific journal article

Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis.

scientific article

Novel mutations confirm that COL11A2 is responsible for autosomal recessive non-syndromic hearing loss DFNB53

scientific article

OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9.

scientific article

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

scientific article

Otopathogenic Pseudomonas aeruginosa Enters and Survives Inside Macrophages

scientific article

Otopathogenic Pseudomonas aeruginosa induces MyD88-dependent auditory hair cell damage

scientific article published on 05 December 2016

PDZD7-MYO7A complex identified in enriched stereocilia membranes.

scientific article published on 15 August 2016

Prelingual deafness: high prevalence of a 30delG mutation in the connexin 26 gene

scientific article

Pseudomonas aeruginosa Activates PKC-Alpha to Invade Middle Ear Epithelial Cells

scientific article published on 4 March 2016

ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.

scientific article

Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2.

scientific article

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

scientific article published on 22 September 2021

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d

scientific article published on 10 March 2016

Role of innate immunity in the pathogenesis of otitis media

scientific article

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

scientific article published on 21 November 2016

Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents.

scientific article published on 25 June 2016

Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

scientific article

Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus

scientific article published on 12 January 2016

The application of genome editing in studying hearing loss

scientific article

Transcription co-factor LBH is necessary for the survival of cochlear hair cells

scientific article published on 13 April 2021

Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons

scientific journal article

Zebrafish Model for Nonsyndromic X-Linked Sensorineural Deafness, DFNX1

scientific article published on 07 April 2019

List of works by Mhamed Grati

A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss

A familial case of Keratitis-Ichthyosis-Deafness (KID) syndrome with the GJB2 mutation G45E

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation

A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness

A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60

Association of PRPS1 Mutations with Disease Phenotypes

CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.

CRISPR: a versatile tool for both forward and reverse genetics research.

Characterization of ATPase Activity of P2RX2 Cation Channel

Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.

Current concepts in the pathogenesis and treatment of chronic suppurative otitis media.

DFNB9 and DFNB12.

Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice

Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family

FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing.

Genetic analysis of Tunisian families with Usher syndrome type 1: toward improving early molecular diagnosis

Immune responses in the mammalian inner ear and their implications for AAV-mediated inner ear gene therapy

Immunity genes and susceptibility to otitis media: a comprehensive review

In vitro interaction of Pseudomonas aeruginosa with human middle ear epithelial cells

Indispensable Role of Ion Channels and Transporters in the Auditory System.

Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.

Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions.

MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform

Methylation Status and Presbycusis Risk in Elderly Women

Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.

Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells

Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis.

Novel mutations confirm that COL11A2 is responsible for autosomal recessive non-syndromic hearing loss DFNB53

OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9.

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

Otopathogenic Pseudomonas aeruginosa Enters and Survives Inside Macrophages

Otopathogenic Pseudomonas aeruginosa induces MyD88-dependent auditory hair cell damage

PDZD7-MYO7A complex identified in enriched stereocilia membranes.

Prelingual deafness: high prevalence of a 30delG mutation in the connexin 26 gene

Pseudomonas aeruginosa Activates PKC-Alpha to Invade Middle Ear Epithelial Cells

ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.

Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2.

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d

Role of innate immunity in the pathogenesis of otitis media

Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents.

Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Tectorins crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus

The application of genome editing in studying hearing loss

Transcription co-factor LBH is necessary for the survival of cochlear hair cells

Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons

Zebrafish Model for Nonsyndromic X-Linked Sensorineural Deafness, DFNX1