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List of works by K. Johan Rosengren

A cactus-derived toxin-like cystine knot Peptide with selective antimicrobial activity

scientific article

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

scientific article published on 26 February 2016

A tripartite approach identifies the major sunflower seed albumins.

scientific article published on 14 January 2016

Alanine and lysine scans of the LL-37 derived peptide fragment KR-12 reveal key residues for antimicrobial activity.

scientific article published on 11 February 2018

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

scientific article

Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate

scientific article published on 17 October 2018

An Ancient Peptide Family Buried within Vicilin Precursors

scientific article published on 25 April 2019

An Orbitide from Ratibida columnifera Seed Containing 16 Amino Acid Residues

scientific article published on 08 August 2019

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

scientific article published on 13 November 2015

Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti

scientific article

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

scientific article published on 21 August 2018

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins.

scientific article

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice.

scientific article published on 25 March 2014

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

scientific article published on 6 June 2015

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

scientific article published on 14 September 2015

Circular proteins from plants and fungi.

scientific article published on 14 June 2012

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

scientific article

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

scientific article published on 26 May 2017

Cyclization of pyrrhocoricin retains structural elements crucial for the antimicrobial activity of the native peptide.

scientific article published in January 2004

Cyclotide Evolution: Insights from the Analyses of Their Precursor Sequences, Structures and Distribution in Violets (Viola).

scientific article published on 18 December 2017

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

scientific article

Defining the Familial Fold of the Vicilin-Buried Peptide Family

scientific article published on 30 September 2020

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

scientific article

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

scientific article published on 27 July 2016

Discovery, structure and biological activities of cyclotides.

scientific article published on 23 May 2009

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

scientific article published on 21 August 2018

Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.

scientific article

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).

scientific article

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

scientific article

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

scientific article published on 22 February 2013

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

scientific article published on 18 May 2015

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

scientific article published on 29 January 2016

Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII.

scientific article

European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes

scientific article published on 02 December 2009

Evolutionary Origins of a Bioactive Peptide Buried within Preproalbumin

scientific article

Extensive polymorphism in the porcine Toll‐like receptor 10 gene

scientific article published on November 11, 2011

Heimdallarchaea encodes profilin with eukaryotic-like actin regulation and polyproline binding

scientific article published on 01 September 2021

How bugs make lassos

scientific article published on 01 December 2009

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

scientific article

Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin.

scientific article published in September 2002

Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium

scientific article

In vitro assays of molecular motors--impact of motor-surface interactions.

scientific article published on May 2008

Insights into the Interaction of LVV-Hemorphin-7 with Angiotensin II Type 1 Receptor

scientific article published on 28 December 2020

Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis

scientific article published on 25 November 2014

Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.

scientific article published on 11 April 2005

Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.

scientific article

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

scientific article published in January 2005

Mature forms of the major seed storage albumins in sunflower: A mass spectrometric approach

scientific article published on 10 May 2016

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

scientific article

NMR and protein structure in drug design: application to cyclotides and conotoxins

scientific article

Natural structural diversity within a conserved cyclic peptide scaffold

scientific article

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain

scientific article published in 2024

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

scientific article published in Scientific Reports

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

scientific article published on 22 March 2018

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

scientific article

Prediction of disulfide dihedral angles using chemical shifts

scientific article published on 05 July 2018

Random coil shifts of posttranslationally modified amino acids

scientific article published on 17 July 2019

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

scientific article published on 02 December 2020

Relaxin family peptides: structure-activity relationship studies.

scientific article published on 6 December 2016

Relaxin-3/RXFP3 system regulates alcohol-seeking

scientific article

Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.

scientific article published in January 2009

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin

scientific article

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

scientific article published on 7 March 2014

Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.

scientific article

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

scientific article

Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina

scientific article

Solution structure, aggregation behavior, and flexibility of human relaxin-2

scientific article

Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant

scientific article

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor

scientific article

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

scientific article

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4.

scientific article published on 20 July 2006

Structural insights into the function of relaxins

scientific article

Structural properties of relaxin chimeras.

scientific article

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

scientific article

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

scientific article

Structures of naturally occurring circular proteins from bacteria

scientific article

Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3.

scientific article published on 20 March 2015

Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).

scientific article

Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo

scientific article published in 2021

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

scientific article published on 22 April 2008

The Cyclic Cystine Ladder in  -Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

scientific article

The conserved glu in the cyclotide cycloviolacin O2 has a key structural role

scientific article

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif

scientific article

The genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

scientific article published on 19 August 2020

The minimal active structure of human relaxin-2

scientific article

The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

scientific article

The self-association of the cyclotide kalata B2 in solution is guided by hydrophobic interactions.

scientific article published on September 2013

The structural determinants of insulin-like Peptide 3 activity

scientific article

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance

scientific article

Three-Dimensional Structure Determination of Peptides Using Solution Nuclear Magnetic Resonance Spectroscopy

scientific article published on 01 January 2020

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

scientific article

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

scientific article published on 23 May 2017

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

scientific article