List of works - Douglas M Fowler

A premalignant cell-based model for functionalization and classification of PTEN variants

scientific article published on 04 May 2020

An Atlas of Variant Effects to understand the genome at nucleotide resolution

An improved platform for functional assessment of large protein libraries in mammalian cells

scientific article published on 01 January 2020

An open-source platform to distribute and interpret data from multiplexed assays of variant effect

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions.

scientific article

Applying Multiplex Assays to Understand Variation in Pharmacogenes

scientific article published on 30 May 2019

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

scientific article published on 08 June 2020

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

scientific article

Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

scientific article published on 05 November 2019

Enrich2: a statistical framework for analyzing deep mutational scanning data

scientific article published on 25 September 2016

High-throughput, microscope-based sorting to dissect cellular heterogeneity

scientific article published on 01 June 2020

Multiplex assessment of protein variant abundance by massively parallel sequencing

article

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

scientific article published on 11 May 2020

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

scientific article published on 01 September 2020

Mutagenesis-based protein structure determination

scientific article published on 01 July 2019

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

scientific article published on 08 December 2021

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

scientific article

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

scientific article published on 01 June 2020

List of works by Douglas M Fowler

A premalignant cell-based model for functionalization and classification of PTEN variants

An Atlas of Variant Effects to understand the genome at nucleotide resolution

An improved platform for functional assessment of large protein libraries in mammalian cells

An open-source platform to distribute and interpret data from multiplexed assays of variant effect

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions.

Applying Multiplex Assays to Understand Variation in Pharmacogenes

Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase

Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning

Enrich2: a statistical framework for analyzing deep mutational scanning data

High-throughput, microscope-based sorting to dissect cellular heterogeneity

Multiplex assessment of protein variant abundance by massively parallel sequencing

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Mutagenesis-based protein structure determination

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs