List of works by Christopher G Sobey

119: PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

scholarly article by Pei Ching (Regine) Low published in November 2014

A flow cytometric method for the analysis of macrophages in the vascular wall

scientific article published on 6 August 2013

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

scientific article published on 16 April 2020

ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

scientific article published on 14 July 2020

Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1.

scientific article published on 30 August 2013

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

scientific article published in January 2015

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke.

scientific article published on 30 January 2018

Adiponectin receptor signalling in the brain

scientific article published on January 2012

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension

scientific article published on 22 December 2016

Aged rats have an altered immune response and worse outcomes after traumatic brain injury

scientific article published on 27 April 2019

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

scientific article published on 30 October 2012

Aldosterone-Induced Hypertension is Sex-Dependent, Mediated by T Cells and Sensitive to GPER Activation

scientific article published on 26 March 2020

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

scientific article

Allopurinol and amlodipine improve coronary vasodilatation after myocardial ischaemia and reperfusion in anaesthetized dogs.

scientific article published in February 1993

Amnion epithelial cells - a novel therapy for ischemic stroke?

article published in 2018

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

scientific article published on 13 December 2016

Angiotensin (1-7) as a therapy to prevent rupture of intracranial aneurysms?

scientific article published on 01 August 2014

Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

scientific article published on 22 October 2012

Antibodies in the pathogenesis of hypertension

scientific article

Apoptotic mechanisms after cerebral ischemia

scientific article published on 29 January 2009

Arachidonate dilates basilar artery by lipoxygenase-dependent mechanism and activation of K(+) channels

scientific article

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

scientific article published on 28 August 2013

Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.

scientific article published on 18 February 2010

Bacteriophages in Natural and Artificial Environments

scientific article published on 12 July 2019

Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model

scientific article published on 27 October 2020

Bradykinin B2 receptor antagonism: a new direction for acute stroke therapy?

scientific article

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

scientific article

Brain infarct volume after permanent focal ischemia is not dependent on Nox2 expression.

scientific article published on 18 September 2012

CEACAM1: an adhesion molecule that limits blood-brain barrier damage by neutrophils after stroke

scientific article published in September 2013

Calsenilin contributes to neuronal cell death in ischemic stroke.

scientific article published on 27 December 2012

Cell-Based Therapies for Stroke: Are We There Yet?

scientific article published on 25 June 2019

Cell-specific mineralocorticoid receptors: future therapeutic targets for stroke?

scientific article published on August 2016

Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase

scientific article published on November 2003

Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome

scientific article

Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species

scientific article published on March 2012

Cholesterol feeding enhances vasoconstrictor effects of products from rabbit polymorphonuclear leukocytes ⬇️

scientific article published on 01 July 1995

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation.

scientific article

Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice

scientific article

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

scientific article

Corrigendum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

scientific article published on 01 April 2016

Danger signals in stroke.

scientific article published on 22 July 2015

Diagnosing and Treating Hypertensive Disorders of Pregnancy? The Answer May Now Be Less BAFF-ling.

scientific article published on 18 September 2017

Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice

scientific article

Dietary Restriction and Epigenetics: Part I

scientific article published on 01 December 2019

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice

scientific article published on 16 October 2009

Editorial: Stem Cells as Targeted Drug Delivery Vehicles

scientific article published on 21 December 2020

Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo.

scientific article published on 5 November 2015

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development.

scientific article published on 23 December 2014

Effect of gender and sex hormones on vascular oxidative stress.

scientific article published on October 2007

Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen.

scientific article published on 24 May 2007

Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter.

scientific article published in January 1997

Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17beta-estradiol

scientific article published on 30 March 2004

Effect of short-term regression of atherosclerosis on reactivity of carotid and retinal arteries

scientific article published on 01 May 1996

Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats.

scientific article

Effect of subarachnoid hemorrhage on dilatation of rat basilar artery in vivo

scientific article published on 01 July 1996

Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles

scientific article published in April 1997

Emerging roles of the γ-secretase-notch axis in inflammation.

scientific article

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

scientific article

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

scientific article published on 24 February 2014

Endothelial NADPH oxidases: which NOX to target in vascular disease?

scientific article

Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries

scientific article published on 8 January 2010

Enhanced vasoconstriction by serotonin in rabbit carotid arteries with atheroma-like lesions in vivo

scientific article published on 01 May 1991

Epigenetic Regulation by Dietary Restriction: Part II

scientific article published on 01 December 2019

Epigenetic regulation of inflammation in stroke.

scientific article published on 26 April 2018

Estrogen: reducing the pressure by arginine vasopressin

scientific article published on 22 December 2020

Evidence That Ly6C(hi) Monocytes are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization.

scientific article

Evidence for a detrimental role of TLR8 in ischemic stroke

scientific article published on 24 October 2013

Evidence of CCR2-independent transmigration of Ly6C(hi) monocytes into the brain after permanent cerebral ischemia in mice.

scientific article

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

scientific article published on 14 January 2017

Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke

scientific article published on 05 September 2018

Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.

scientific article published in April 2001

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.

scientific article published on 16 October 2013

Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo

scientific article published on 15 July 2004

Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke

scientific article published on 30 March 2011

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress.

scientific article published on 26 August 2014

Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice

scientific article published on 16 October 2009

Evidence that the EphA2 receptor exacerbates ischemic brain injury

scientific article

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

scientific article published in April 2018

Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase

scientific article

Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species

scientific article published on 10 February 2009

Gene Transfer of CGRP Prevents Cerebral Vasoconstriction after Subarachnoid Hemorrhage.

scientific article

Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver

scientific article published on 01 July 2019

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

scientific article published on 22 January 2016

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s).

scientific article

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

scientific article published in February 2018

Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population

scientific article published on 14 December 2020

IL-1β and IL-18: inflammatory markers or mediators of hypertension?

scientific article

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

scientific article published on 20 September 2018

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

scientific article published on 06 May 2019

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia.

scientific article published on 11 December 2013

Immune mechanisms in vascular disease and stroke

scientific article published on 14 August 2014

Immune mechanisms of hypertension.

scientific article

Immunity and hypertension: New targets to lighten the pressure

scientific article published on 01 June 2019

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke

scientific article published on 25 June 2009

Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia.

scientific article published in February 2012

Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo

scientific article

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.

scientific article published on 23 June 2015

Influence of gender on K+-induced cerebral vasodilatation

scientific article published on 5 February 2004

Inhibitory effects of protein kinase C on inwardly rectifying K+- and ATP-sensitive K+ channel-mediated responses of the basilar artery

scientific article

Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke.

scientific article published in January 2017

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke.

scientific article

Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

scientific article published on 27 April 2012

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

scientific article published on 05 September 2013

Inwardly rectifying potassium channels in the regulation of vascular tone

scientific article

Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights.

scientific article published on January 2007

Knockout blow for channel identity crisis : vasodilation to potassium is mediated via Kir2.1.

scientific article published on 01 July 2000

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH.

scientific article published on 21 November 2017

Local injection of Endothelin-1 in the early neonatal rat brain models ischemic damage associated with motor impairment and diffuse loss in brain volume

scientific article published on 06 October 2018

M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure.

scientific article published on 12 June 2015

Maintaining High-Quality Multidisciplinary Pain Medicine Fellowship Programs: Part I: Innovations in Pain Fellows' Education, Research, Applicant Selection Process, Wellness, and ACGME Implementation During the COVID-19 Pandemic

scientific article published on 29 April 2020

Maintaining high quality multidisciplinary pain medicine fellowship programs: Part II: Innovations in clinical care workflow, clinical supervision, job satisfaction and postgraduation mentorship for pain fellows during the Covid-19 pandemic

scientific article published on 07 May 2020

Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring

scientific article published on November 2011

Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide

scientific article

Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats

scientific article published on 16 June 2008

Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels

scientific article published on 01 November 1997

Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion

scientific article published on 10 April 2019

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

scientific article

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

scientific article published on 16 December 2012

NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries

scientific article

NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2.

scientific article published on 21 November 2008

NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival.

scientific article

NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts

scientific article published on 23 March 2012

NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition.

scientific article published on 28 August 2008

NADPH-induced contractions of mouse aorta do not involve NADPH oxidase: a role for P2X receptors

scientific article published on 11 January 2006

NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke

scientific article published on 31 July 2006

NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis.

scientific article published on February 2015

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

article

NOX2β: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages

scientific article

Necrotizing Fasciitis as a Complication of a Continuous Sciatic Nerve Catheter Using the Lateral Popliteal Approach

scientific article

Neurogenic atherosclerosis mediated by neuropeptide y: hardening of the evidence

scientific article published on 01 July 2003

Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats.

scientific article published in April 2002

Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo.

scientific article

Nitroxyl (HNO) as a vasoprotective signaling molecule.

scientific article

Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity.

scientific article published on 28 February 2013

Nitroxyl, the novel redox sibling of NO, suppresses cerebrovascular NADPH oxidase

scientific article published on 11 August 2009

Notch signaling and neuronal death in stroke.

scientific article published on 21 March 2018

Novel isoforms of NADPH-oxidase in cerebral vascular control.

scientific article

Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models.

scientific article published on January 2010

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.

scientific article

Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke.

scientific article

Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension

scientific article published on 8 September 2015

Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension

scientific article published on 2 March 2005

Over-expression of DSCR1 protects against post-ischemic neuronal injury

scientific article

Oxidative stress and endothelial dysfunction in cerebrovascular disease

scientific article published on January 2011

PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

scientific article

Pathogenesis of acute stroke and the role of inflammasomes.

scientific article published on September 2013

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

scientific article

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage and dysfunction in salt-sensitive hypertension

scientific article published on 01 March 2019

Phase 1 Trial of Amnion Cell Therapy for Ischemic Stroke.

scientific article

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain.

scientific article published on 3 February 2015

Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells

scientific article published on January 2012

Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate

scientific article published on 01 November 1998

Potential Efficacy of Amnion Epithelial Cells to Treat Post-stroke Inflammation

scientific article published in 2014

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

scientific article published on 28 June 2017

Prevention of ischaemia-induced coronary vascular dysfunction.

scientific article published on December 1997

Radicals spark interest in cerebral vasodilator mechanisms. Focus on "TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation".

scientific article published in April 2006

Reactive oxygen species in the cerebral circulation: are they all bad?

scientific article published on July 2006

Reactive oxygen species in the cerebral circulation: physiological roles and therapeutic implications for hypertension and stroke

scientific article published in January 2004

Recent evidence for an involvement of rho-kinase in cerebral vascular disease

scientific article published on 29 June 2006

Reduced cerebrovascular remodeling and functional impairment in spontaneously hypertensive rats following combined treatment with suboptimal doses of telmisartan and ramipril: is less really more?

scientific article published on July 2010

Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice.

scientific article published on 23 January 2009

Reflex epicardial coronary vasoconstriction elicited by nicotine in anaesthetized dogs.

scientific article published in April 1989

Requirement for endothelium-derived nitric oxide in vasodilation produced by stimulation of cholinergic nerves in rat hindquarters

scientific article published in June 1994

Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice

scientific article published on 01 October 2012

Risk of Major Cardiovascular Events in People with Down Syndrome

scientific article published on 30 September 2015

Role of CCR2 in inflammatory conditions of the central nervous system

scientific article

Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain

scientific article published on 24 May 2012

Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivo

scientific article published in December 2000

Role of potassium channels in regulation of cerebral vascular tone

scientific article published on 01 October 1998

Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation

scientific article published in March 1999

Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension

scientific article

Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction

scientific article published in February 2006

Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke.

scientific article

Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable

scientific article published on 23 August 2019

Signalling pathways activated by hydrogen peroxide in vascular smooth muscle

scientific article published on 01 November 2005

Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection

scientific article published on 10 November 2019

Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice

scientific article published in August 2012

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease

scientific article published on 27 December 2005

Targeting the Immune System for Ischemic Stroke

scientific article published on 16 December 2020

The BJP expects authors to share data

scientific article published on 01 December 2019

The Vascular Consequences of Metabolic Syndrome: Rodent Models, Endothelial Dysfunction, and Current Therapies

scientific article published on 04 March 2020

The anti-platelet effects of apocynin in mice are not mediated by inhibition of NADPH oxidase activity

scientific article published on September 2010

The need to incorporate aged animals into the preclinical modeling of neurological conditions

scientific article published on 23 December 2019

The opposing roles of NO and oxidative stress in cardiovascular disease.

scientific article published on 14 December 2016

Transcriptome Analysis Reveals Intermittent Fasting-Induced Genetic Changes in Ischemic Stroke

scientific article published on 13 February 2018

Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

scientific article

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

scientific article published on 3 August 2017

Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts

scientific article published on September 2017

Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress

scientific article published on 08 August 2012

Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention

scientific article published on 07 April 2010

Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia

scientific article published on July 1996

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice

scientific article published on 27 February 2011

Vascular rho kinases and their potential therapeutic applications

scientific article published on September 2007

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

scientific article published on 10 January 2017

Vasoconstrictor responses to polymorphonuclear leucocytes from atherosclerotic rabbits

scientific article published on 01 February 1994

Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia

scientific article published on 29 July 2011

Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries

scientific article published on 8 January 2007

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

scientific article published on 17 April 2020

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke.

scientific article published on 23 February 2018

microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke

scientific article published on 11 July 2019

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