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List of works by David M Thomas

"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic

scientific article

5-fluorouracil: a pharmacological paradigm in the use of cytotoxics

scientific article published on 01 November 1998

A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article

A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia

scientific article published on September 2005

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

article

A comparison of Australian and French families affected by sarcoma: perceptions of genetics and incidental findings

article

A newly characterized human well-differentiated liposarcoma cell line contains amplifications of the 12q12-21 and 10p11-14 regions.

scientific article published on 08 June 2012

A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

scientific article

A quantitative model to predict pathogenicity of missense variants in the TP53 gene

scientific article published on 18 March 2019

A role for alphaV integrin subunit in TGF-beta-stimulated osteoclastogenesis

scientific article published in August 2003

Abstract 4593: Genome-wide association study identifies novel loci associated with osteosarcoma

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts of the 10th Congress of the European Association of NeuroOncology. Marseille, France. September 6-9, 2012

scientific article published in September 2012

Accepting risk in the acceleration of drug development for rare cancers

scientific article published on April 2015

Adolescent and Young Adult Oncology: An Emerging Field

scientific article published on 23 August 2010

Adolescent and young adult cancer: a revolution in evolution?

scientific article published in May 2006

Adolescents and young adults with cancer: the challenge

scientific article published on 01 June 2007

An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development

scientific article published in November 2005

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

scientific article

Atypical Ewing sarcoma breakpoint region 1 fluorescence in-situ hybridization signal patterns in bone and soft tissue tumours: diagnostic experience with 135 cases.

scientific article

Author Correction: Diagnosis of fusion genes using targeted RNA sequencing

scientific article published on 08 April 2020

Author Correction: Therapeutic implications of germline genetic findings in cancer

scientific article published on 01 June 2019

Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis

scientific article

Benefits and adverse events in younger versus older patients receiving adjuvant chemotherapy for colon cancer: findings from the Adjuvant Colon Cancer Endpoints data set

scientific article

Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis

scientific article

Cancer 2015: a longitudinal whole-of-system study of genomic cancer medicine.

scientific article published on 19 October 2015

Cancer-associated neochromosomes: a novel mechanism of oncogenesis.

scientific article

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

scientific article

ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data

scientific article published on 25 February 2021

Clinical Overview of MDM2/X-Targeted Therapies

scientific article

Clinical implications of genomics for cancer risk genetics

scientific article published on 27 May 2015

Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3).

scientific article

Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis

scientific article published on 15 December 2010

Cost-effectiveness of precision medicine in the fourth-line treatment of metastatic lung adenocarcinoma: An early decision analytic model of multiplex targeted sequencing

scientific article published on 2 June 2016

Counterpoints in cancer: The somatic mutation theory under attack ⬇️

scientific article published on 01 May 2011

Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology

scientific article published on 23 June 2021

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

scientific article published on 16 April 2021

Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.

scientific article published on August 2009

Cyclin E1 is amplified and overexpressed in osteosarcoma.

scientific article

Dendritic cell immunotherapy for stage IV melanoma

scientific article published on 01 October 2007

Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

scientific article published on 18 June 2012

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study.

scientific article

Denosumab: a new treatment option for giant cell tumor of bone.

scientific article

Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk

scientific article published on 17 February 2018

Dexamethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line.

scientific article published on August 1996

Diagnosis and Management of Hereditary Sarcoma

scientific article published in January 2016

Diagnosis of fusion genes using targeted RNA sequencing

article

Distinguishing activity from progress.

scientific article

Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

scientific article

Epigenetic modifications in osteogenic differentiation and transformation.

scientific article

Estimating TP53 Mutation Carrier Probability in Families with Li-Fraumeni Syndrome Using LFSPRO.

scientific article published on 30 January 2017

Etiologic, environmental and inherited risk factors in sarcomas.

scientific article

Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk

scientific article published on 27 October 2011

Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas

scientific article published on 01 July 2019

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

scientific article

FISH analysis of selected soft tissue tumors: Diagnostic experience in a tertiary center

scientific article published on 28 May 2018

Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma.

scientific article

Gender differences in doxorubicin pharmacology for subjects with chemosensitive cancers of young adulthood

scientific article published on 11 September 2018

Gender-specific activity of chemotherapy correlates with outcomes in chemosensitive cancers of young adulthood.

scientific article

Gene expression profiling of sarcomas

scientific article published on 01 April 2006

Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

scientific article published on 6 December 2017

Genome-wide association study identifies two susceptibility loci for osteosarcoma

scientific article (publication date: July 2013)

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

scientific article (publication date: May 2007)

Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases.

scientific article

Giant cell tumour of bone.

scientific article published on July 2009

High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.

scientific article

Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts

article

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

scientific article

Impact of young age on treatment efficacy and safety in advanced colorectal cancer: a pooled analysis of patients from nine first-line phase III chemotherapy trials

scientific article published on 06 June 2011

Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice.

scholarly article

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014

Insulin receptor expression in primary and cultured osteoclast-like cells

scientific article published on 01 September 1998

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.

scientific article

International survey of awareness of genetic risk in the clinical sarcoma community

scientific article published on 29 February 2016

Is Li-Fraumeni syndrome really much more common?

scientific article published on 01 December 2017

Lessons from the deep study of rare tumours

scientific article published on 01 July 2011

Li-Fraumeni syndrome: cancer risk assessment and clinical management

scientific article published on 18 March 2014

Liposarcoma: molecular genetics and therapeutics.

scientific article published on 27 December 2010

Locally Aggressive Connective Tissue Tumors.

scientific article published on 8 December 2017

Lung cancer in motor exhaust-related occupations

scientific article published on 01 January 1989

MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

scientific article published on 01 June 2020

Management of sarcoma in the Asia-Pacific region: resource-stratified guidelines.

scientific article

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

scientific article published on December 2013

Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation

scientific article published on 01 March 1999

Medical Research Council adjuvant trial in high-grade gliomas

scientific article

Molecular medicine: a clinician's primer on microarrays.

scientific article published in September 2004

Molecular pathogenesis of osteosarcoma.

scientific article published on January 2007

Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB

scientific article

Monogenic and polygenic determinants of sarcoma risk: an international genetic study

scientific article

Mouse Models of Tumor Immunotherapy

scientific article published on 19 January 2016

Multidisciplinary approach to diagnosis and management of osteosarcoma - a review of the St Vincent's Hospital experience.

scientific article

Multiomics medicine in oncology: assessing effectiveness, cost-effectiveness and future research priorities for the molecularly unique individual.

scientific article published on September 2013

Next-generation sequence analysis of cancer xenograft models.

scientific article

Novel Approaches to Treatment of Leiomyosarcomas ⬇️

scientific article published on August 1, 2011

Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling

scientific article published on 13 December 2013

Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer

scientific article published on 4 April 2018

Optimising the management of soft tissue tumours ⬇️

scientific article published on June 1, 2011

Outcomes of patients with non-melanoma solid tumours receiving self-funded pembrolizumab at Chris O'Brien Lifehouse

scientific article

PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma

scientific article

Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ.

scientific article published in September 2009

Patient perspectives on molecular tumor profiling: "Why wouldn't you?"

scientific article published on 31 July 2019

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes

scientific article

Possible pro-carcinogenic effect of endotoxin on lung cancer in an extended follow-up of Shanghai women textile workers

abstract published in 2014

Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial

scientific article published on May 2015

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.

scientific article published on 11 August 2012

Progress in management of acute myeloid leukaemia (AML) in Australia since 1980: a single institution retrospective study

scientific article published on 01 April 1998

Prolonged disease-free survival with specific re-induction therapy in acute myeloid leukaemia relapsing following bone marrow transplantation

scientific article published on 01 December 1997

Proportion of lung cancers in males, due to occupation, in different areas of the USA.

scientific article published in December 1988

Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?

scientific article published on 25 January 2017

RANKL, denosumab, and giant cell tumor of bone.

scientific article published on July 2012

RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma

scientific article published on 3 January 2014

RECK in osteosarcoma: a novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model

scientific article published on 01 February 2011

RECK--a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer

scientific article published on December 2007

Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis.

scientific article

Retrospective survey of unselected hospital patients with and without cancer comparing outcomes following venous thromboembolism

scientific article published on 01 September 2002

STI-571 inhibits in vitro angiogenesis.

scientific article published in October 2003

Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study

scientific article published on 16 July 2013

Safety of denosumab in giant-cell tumour of bone

scientific article published on 01 September 2010

Sarcoma and germ-line DICER1 mutations - Authors' reply.

scientific article

Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

scientific article

Sociodemographic, psychosocial and clinical factors associated with uptake of genetic counselling for hereditary cancer: a systematic review

scientific article published on 19 September 2016

Starting an adolescent and young adult program: some success stories and some obstacles to overcome.

scientific article published on 17 May 2010

Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets.

scientific article

Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

scientific article

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging.

scientific article

Surveillance recommendations for patients with germline TP53 mutations.

scientific article

Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells

scientific article published on 28 February 2013

Synchronous diagnosis of Hodgkin lymphoma and osteosarcoma

scientific article published on 01 October 2007

Targeting the p53 Pathway in Ewing Sarcoma.

scientific article

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

scientific article

The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology

scientific article

The Hippo pathway and human cancer.

scientific article published on 07 March 2013

The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

scientific article published on 23 January 2020

The Medical Genome Reference Bank: a whole-genome data resource of 4000 healthy elderly individuals. Rationale and cohort design

scientific article published on 24 October 2018

The PiGeOn project: protocol of a longitudinal study examining psychosocial and ethical issues and outcomes in germline genomic sequencing for cancer.

scientific article published on 23 April 2018

The STATs in cell stress-type responses

scientific article

The distinctive biology of cancer in adolescents and young adults.

scientific article published on April 2008

The growing problem of benign connective tissue tumours.

scientific article

The hard and soft sides of cancer programming

scientific article published on 01 October 2010

The life history of neochromosomes revealed.

scientific article published on 23 January 2015

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

scientific article

The promise of PET in clinical management and as a sensitive test for drug cytotoxicity in sarcomas.

scientific article published on January 2008

The relationship between unmet needs and distress amongst young people with cancer.

scientific article published on 11 February 2011

The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

scientific article published in August 2001

Therapeutic implications of germline genetic findings in cancer

scientific article published on 01 June 2019

Timing and context: important considerations in the return of genetic results to research participants

scientific article

Translating genomic risk into an early detection strategy for sarcoma

scientific article published on 29 November 2018

Translational biology of osteosarcoma

scientific article

Who should access germline genome sequencing? A mixed methods study of patient views

scientific article published on 26 November 2019

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

scientific article published on 05 October 2020

Wiki-based clinical practice guidelines for the management of adult onset sarcoma: a new paradigm in sarcoma evidence.

scientific article

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

scientific article (publication date: April 2009)

Wnts, bone and cancer.

scientific article published in January 2010

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