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List of works by David M Thomas

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The Hippo pathway and human cancer.

scientific article published on 07 March 2013
Translational biology of osteosarcoma

scientific article
Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study.

scientific article
The distinctive biology of cancer in adolescents and young adults.

scientific article published on April 2008
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

scientific article published in August 2001
Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study

scientific article published on 16 July 2013
Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

scientific article published on 18 June 2012
Molecular pathogenesis of osteosarcoma.

scientific article published on January 2007
Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis.

scientific article
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

scientific article (publication date: April 2009)
Genome-wide association study identifies two susceptibility loci for osteosarcoma

scientific article (publication date: July 2013)
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

scientific article
High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.

scientific article published on 21 December 2006
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

scientific article
Clinical Overview of MDM2/X-Targeted Therapies

scientific article
Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

scientific article
RECK--a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer

scientific article published on December 2007
Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

scientific article
Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial

scientific article published on May 2015
Li-Fraumeni syndrome: cancer risk assessment and clinical management

scientific article published on 18 March 2014
Giant cell tumour of bone.

scientific article published on July 2009
Monogenic and polygenic determinants of sarcoma risk: an international genetic study

scientific article
Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015
Starting an adolescent and young adult program: some success stories and some obstacles to overcome.

scientific article published on 17 May 2010
Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis

scientific article
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

journal article published in 2014
Liposarcoma: molecular genetics and therapeutics.

scientific article published on 27 December 2010
Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB

scientific article
Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis

scientific article published on 15 December 2010
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma

scientific article
Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation

scientific article published on 01 March 1999
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

scientific article
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice.

scholarly article
The relationship between unmet needs and distress amongst young people with cancer.

scientific article published on 11 February 2011
The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology

scientific article
Adolescent and young adult cancer: a revolution in evolution?

scientific article published in May 2006
Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis

scientific article
5-fluorouracil: a pharmacological paradigm in the use of cytotoxics

scientific article published on 01 November 1998
Adolescent and Young Adult Oncology: An Emerging Field

scientific article published on 23 August 2010
An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development

scientific article published in November 2005
Epigenetic modifications in osteogenic differentiation and transformation.

scientific article
Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

scientific article published on December 2013
RANKL, denosumab, and giant cell tumor of bone.

scientific article published on July 2012
Cyclin E1 is amplified and overexpressed in osteosarcoma.

scientific article
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

scientific article
A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia

scientific article published on September 2005
Insulin receptor expression in primary and cultured osteoclast-like cells

scientific article published on 01 September 1998
The STATs in cell stress-type responses

scientific article
Impact of young age on treatment efficacy and safety in advanced colorectal cancer: a pooled analysis of patients from nine first-line phase III chemotherapy trials

scientific article published on 06 June 2011
Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

scientific article

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