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List of works by Harikrishna Nakshatri

2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells

scientific article published on January 2007

A Spectrum Graph-Based Protein Sequence Filtering Algorithm for Proteoform Identification by Top-Down Mass Spectrometry.

scientific article published in November 2017

A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples

scientific article

A system for detecting high impact-low frequency mutations in primary tumors and metastases

scientific article published on 11 September 2017

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.

scientific article

A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.

scientific article

AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer.

scientific article published on 06 October 2008

ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer.

scientific article published on 05 July 2013

Aberrant epigenetic and transcriptional events associated with breast cancer risk

scientific article published on 09 February 2022

Activity and enhancer binding factors for BK virus regulatory elements in differentiating embryonal carcinoma cells.

scientific article published in July 1991

Activity and enhancer binding factors for JC virus regulatory elements in differentiating embryonal carcinoma cells

scientific article

Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype

scientific article published on 07 October 2021

Amplified in breast cancer 1 expression in breast cancer.

scientific article

An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.

scientific article published on 3 April 2018

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.

scientific article published in February 2014

Antimyeloma effects of a sesquiterpene lactone parthenolide.

scientific article

Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.

scientific article published on September 2004

Antitumor properties of novel sesquiterpene lactone analogs as NFκB inhibitors that bind to the IKKβ ubiquitin-like domain (ULD)

scientific article published on 30 June 2021

Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions.

scientific article

Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4

scientific article published on 01 August 1998

Biomarkers for breast cancer stem cells: the challenges ahead

scientific article published on October 2011

Breast Heterogeneity: Obstacles to Developing Universal Biomarkers of Breast Cancer Initiation and Progression

scientific article published on 17 April 2020

Breast cancer cell detection and characterization from breast milk-derived cells

scientific article published on 15 September 2020

Breast cancer stem cells and intrinsic subtypes: controversies rage on.

scientific article published on January 2009

Breast-cancer stem cells-beyond semantics

scientific article published on January 2012

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

scientific article published on January 2006

CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.

scientific article

Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle

scientific article

Cancer cell-derived interleukin 1alpha contributes to autocrine and paracrine induction of pro-metastatic genes in breast cancer

scientific article published on 01 August 2000

Cell competition and tumor heterogeneity

scientific article published on 09 September 2019

Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells

scientific article

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

scientific article published on 28 June 2019

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse.

scientific article

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.

scientific article published on 2 May 2018

Differential effect of Nonidet P40 on DNA binding of transcription factors.

scientific article published on June 1997

Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel

scientific article

Differential whole-cell extract preparation and electrophoretic mobility shift assay to evaluate the effect of tyrosine phosphatases on DNA binding activity of transcription factors

scientific article published on 01 April 1996

Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy.

scientific article published on 20 April 2016

Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast

scientific article published on 16 April 2019

Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer.

scientific article published on 31 August 2007

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

scientific article published on March 2006

Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling.

scientific article published on 13 July 2018

Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase

scientific article published on August 2007

Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase

scientific article

Essential Components of Cancer Education

scientific article

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

scientific article published on 14 June 2009

Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization.

scientific article

Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores.

scientific article published on 27 November 2009

FOXA1 Expression in Breast Cancer Correlation with Luminal Subtype A and Survival

scientific article published on 01 August 2007

FOXA1 as a therapeutic target for breast cancer

scientific article

FOXA1 in breast cancer

scientific article

FOXA1 is an independent prognostic marker for ER-positive breast cancer.

scientific article published on 19 April 2011

Flower isoforms promote competitive growth in cancer

scientific article published on 24 July 2019

Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis.

scientific article

Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein

scientific article published on 01 April 2001

Genetic Ancestry-dependent Differences in Breast Cancer-induced Field Defects in the Tumor-adjacent Normal Breast

scientific article published on 04 February 2019

HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression

scientific article published on 05 July 2013

HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance

scientific article

High-level expression of forkhead-box protein A1 in metastatic prostate cancer

scientific article published on 14 March 2011

ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer

scientific article

Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity.

scientific article published on January 2013

Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells

scientific article published on 01 March 2002

Identity profiling of cell surface markers by multiplex gold nanorod probes

scientific article

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice

scientific article published on 04 June 2020

Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells.

scientific article

Inflammation-associated microRNA changes in circulating exosomes of heart failure patients

scientific article published on 19 December 2017

Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.

scientific article

Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.

scientific article published on 29 July 2004

Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis

scientific article published on 04 April 2017

Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer

scientific article published on 06 December 2019

Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer.

scientific article published in December 2003

Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing

scientific article

Intrinsic subtype-associated changes in the plasma proteome in breast cancer.

scientific article published on November 2009

Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells.

scientific article published in September 1996

Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: insights from PyMT transgenic mouse model.

scientific article

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

scientific article published on 10 August 2018

MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters.

scientific article published on 17 October 2007

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer.

scientific article published on 25 April 2016

Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element ⬇️

scientific article published on November 15, 1991

Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements.

scientific article

Mutational landscape of RNA-binding proteins in human cancers

scientific article

NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha.

scientific article published on June 1998

NF-kappaB and breast cancer

scientific article

NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy.

scientific article published on 20 March 2009

NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4

scientific article published on 09 April 2003

NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT

scientific article

Negative regulation of MHC class II gene expression by CXCR4.

scientific article published on August 2006

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.

scientific article published on 27 November 2006

Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells

scientific article published on 01 June 1999

Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade

scientific article published on 11 July 2018

Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.

scientific article

Obesity potentiates the growth and dissemination of pancreatic cancer

scientific article

Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications.

scientific article published on 15 September 2008

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

scientific article published in May 2015

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells

scientific article published on 16 May 2018

PROGgene: gene expression based survival analysis web application for multiple cancers.

scientific article published on 28 October 2013

PROGgeneV2: enhancements on the existing database

scientific article published on 17 December 2014

PROGmiR: a tool for identifying prognostic miRNA biomarkers in multiple cancers using publicly available data

scientific article

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide

scientific article published on 01 August 2000

Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

scientific article

Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair.

scientific article published on December 2007

Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

scientific article published on 13 September 2011

Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer

scientific article published on 4 October 2017

Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.

scientific article

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

scientific article (publication date: 30 March 2001)

Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.

scientific article

Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet

scientific article

Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment.

scientific article published on 13 November 2009

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

scientific article published on September 1992

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently

scientific article (publication date: 24 January 1992)

Radiation resistance in breast cancer: are CD44+/CD24-/proteosome low/PKH26+ cells to blame?

scientific article published on 7 April 2010

RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants

scientific article published on 25 May 2017

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.

scientific article

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

scientific article published on June 2000

Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model

scientific article published on October 2006

Retinoic acid signal transduction pathways.

scientific article published on June 1993

Role of AKT isotypes in breast cancer

scientific article published on 01 February 2013

SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype.

scientific article

Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion

scientific article published on 14 February 2020

Stage and tissue-specific expression of the alcohol dehydrogenase 1 (Adh-1) gene during mouse development.

scientific article published in March 1994

Statistical modeling for sensitive detection of low-frequency single nucleotide variants

scientific article

Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase

scientific article

Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications

scientific article

Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.

scientific article published on 31 May 2007

Systemic Actions of Breast Cancer Facilitate Functional Limitations

scientific article published on 13 January 2020

TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis.

scientific article published on 10 July 2015

TNFalpha resistance in MCF-7 breast cancer cells is associated with altered subcellular localization of p21CIP1 and p27KIP1

scientific article published on 01 January 2005

The first 124 nucleotides of the E7 coding sequences of HPV16 can render the HPV11 genome transformation competent

scientific article published on January 1992

The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells

scientific article published on 27 January 2005

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes

scientific article published on 9 April 2014

The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2

scientific article published on 01 April 2000

The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.

scientific article

The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.

scientific article published on November 2006

The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.

scientific article published on June 2005

Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling

scientific article published on 29 July 2008

Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity

scientific article published on 12 January 2022

Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function

scientific article published on February 2004

Ubiquitous and cell-type-specific protein interactions with human papillomavirus type 16 and type 18 enhancers

scientific article

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

scientific article published on 4 October 2011

regSNPs-ASB: A Computational Framework for Identifying Allele-Specific Transcription Factor Binding From ATAC-seq Data

scientific article published on 29 July 2020

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