List of works - J. Timothy Greenamyre

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

scientific article (publication date: December 2000)

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

scientific article published on August 2002

Mechanism of toxicity in rotenone models of Parkinson's disease

scientific article

Alternative excitotoxic hypotheses

scientific article published on April 1, 1992

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

scientific article

A highly reproducible rotenone model of Parkinson's disease

scientific article

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

scientific article

Animal models of Parkinson's disease.

scientific article

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

scientific article

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

scientific article

Excitatory amino acids and Alzheimer's disease

scientific article published on September 1989

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

scientific article published on 24 January 2006

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

scientific article

Glutamate and Parkinson's disease

scientific article

Mitochondrial dysfunction in Parkinson's disease.

scientific article

Complex I and Parkinson's disease

scientific article

NMDA receptor losses in putamen from patients with Huntington's disease

scientific article

Selective microglial activation in the rat rotenone model of Parkinson's disease

scientific article published in May 2003

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

scientific article published on August 2000

The role of glutamate in neurotransmission and in neurologic disease

scientific article

Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication

scientific article

Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment.

scientific article

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

scientific article published on June 2016

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

scientific article published on 19 October 2013

Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

scientific article published on 4 January 2007

The role of environmental exposures in neurodegeneration and neurodegenerative diseases

scientific article published on 13 September 2011

Dopaminergic Neurons Intrinsic to the Primate Striatum

scientific article published on September 1, 1997

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys

scientific article published on November 1, 1991

Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

scientific article published on September 2005

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

scientific article published on 6 January 2005

Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism

scientific article

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.

scientific article published on 10 July 2009

The rotenone model of Parkinson's disease: genes, environment and mitochondria

scientific article

N-Methyl-d-Aspartate Antagonists in the Treatment of Parkinson's Disease

scientific article published on September 1, 1991

PCR based determination of mitochondrial DNA copy number in multiple species

scientific article

Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding

scientific article published in February 1987

Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases

scientific article published in March 1985

Ubiquitin-proteasome system and Parkinson's diseases

scientific article

Neurotoxic in vivo models of Parkinson's disease recent advances.

scientific article

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

scientific article

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

scientific article published on January 15, 2013

Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial

scientific article published in July 2005

Glutamate transmission and toxicity in Alzheimer's disease

scientific article published on January 1988

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

scientific article published on 01 September 1993

Toxin models of mitochondrial dysfunction in Parkinson's disease.

scientific article published on 12 July 2011

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system

scientific article published on August 1, 1984

Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease

scientific article

Environment, mitochondria, and Parkinson's disease

scientific article

Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade.

scientific article

List of works by J. Timothy Greenamyre

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

Mechanism of toxicity in rotenone models of Parkinson's disease

Alternative excitotoxic hypotheses

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

A highly reproducible rotenone model of Parkinson's disease

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

Animal models of Parkinson's disease.

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

Excitatory amino acids and Alzheimer's disease

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

Glutamate and Parkinson's disease

Mitochondrial dysfunction in Parkinson's disease.

Complex I and Parkinson's disease

NMDA receptor losses in putamen from patients with Huntington's disease

Selective microglial activation in the rat rotenone model of Parkinson's disease

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

The role of glutamate in neurotransmission and in neurologic disease

Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication

Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment.

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

The role of environmental exposures in neurodegeneration and neurodegenerative diseases

Dopaminergic Neurons Intrinsic to the Primate Striatum

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys

Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology.

The rotenone model of Parkinson's disease: genes, environment and mitochondria

N-Methyl-d-Aspartate Antagonists in the Treatment of Parkinson's Disease

PCR based determination of mitochondrial DNA copy number in multiple species

Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding

Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases

Ubiquitin-proteasome system and Parkinson's diseases

Neurotoxic in vivo models of Parkinson's disease recent advances.

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial

Glutamate transmission and toxicity in Alzheimer's disease

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

Toxin models of mitochondrial dysfunction in Parkinson's disease.

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system

Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease

Environment, mitochondria, and Parkinson's disease

Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade.