List of works by Karen E. Pollok

3552 Advancing Glioblastoma (GBM) drug regimen development to support combination therapy through integrated PKPD modeling and simulation-based predictions

A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo

scientific article published on 31 January 2014

A novel competitive repopulation strategy to quantitate engraftment of ex vivo manipulated murine marrow cells in submyeloablated hosts

scientific article published on 4 February 2008

A theoretically optimized method for cord blood stem cell cryopreservation

scientific article

ATPS-75TARGETING THE Mdm2-Akt SIGNALING NETWORK IN COMBINATION WITH TEMOZOLOMIDE IMPROVES EFFICACY IN ECTOPIC AND ORTHOTOPIC PATIENT-DERIVED GLIOBLASTOMA XENOGRAFT MODELS.

scientific article

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma.

scientific article published on 6 April 2018

Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target

scientific article published on 9 July 2015

Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential

scientific article

Chemotherapeutic selectivity conferred by selenium: a role for p53-dependent DNA repair

scientific article published on 01 January 2007

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

scientific article

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

scientific article published on April 2003

Design, synthesis, and evaluation of curcumin-derived arylheptanoids for glioblastoma and neuroblastoma cytotoxicity

scientific article

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice

scientific article

Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer

scientific article

ET-25THERAPEUTIC MODULATION OF MDM2 IN NEUROBLASTOMA

scientific article published in November 2014

Emerging targets for glioblastoma stem cell therapy

scientific article published on 20 September 2015

Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines.

scientific article published on 19 December 2014

Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A

scientific article published on July 2009

Evaluation of plasmid DNA removal from lentiviral vectors by benzonase treatment

scientific article published in February 2004

Exploring a structural protein-drug interactome for new therapeutics in lung cancer

scientific article

G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer

scientific article published on 9 August 2006

Gene Co-Expression Networks Restructured Gene Fusion in Rhabdomyosarcoma Cancers

scientific article published on 30 August 2019

Generation of Stable Vector-Producing Cells for Retroviral Vectors

scientific article published on 01 April 2008

Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs.

scientific article published on June 2015

Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea

scientific article

Human proangiogenic circulating hematopoietic stem and progenitor cells promote tumor growth in an orthotopic melanoma xenograft model

scientific article

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

scientific article

Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium

scientific article published on 5 August 2016

Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy

scientific article published on 08 September 2016

Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood

scientific article

Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells

scientific article published on August 2008

Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

scientific article

In Vivo Measurements of Tumor Metabolism and Growth after Administration of Enzastaurin Using Small Animal FDG Positron Emission Tomography

scientific article published on 27 May 2009

In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells

scientific article published on 19 January 2006

In vivo protection of hematopoietic cells from alkylator-mediated DNA damage

scientific article

In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector

scientific article published on March 2008

In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

scientific article published in December 2003

Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice

scientific article published on 01 June 2007

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia

scientific article published on 26 June 2008

Lentiviral vectors pseudotyped with glycoproteins from Ross River and vesicular stomatitis viruses: variable transduction related to cell type and culture conditions

scientific article published in March 2005

Letrozole targets the Human ether-a-go-go-related gene (HERG) potassium current in glioblastoma

scientific article published on 11 October 2020

Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice

scientific article

Melanoma LAMP-2C Modulates Tumor Growth and Autophagy

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo

scientific article published on 07 January 2009

Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents

scientific article published in April 2005

Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development

scientific article (publication date: 2014)

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14

scientific article published in Scientific Reports

PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice

scientific article published on 21 October 2005

PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells

scientific article

Peripheral blood biomarkers of solid tumor angiogenesis in dogs: a polychromatic flow cytometry pilot study

scientific article published on 12 October 2012

Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

scientific article published on 03 April 2020

Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool.

scientific article

Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis

scientific article

Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.

scientific article

Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma

scientific article published on 15 June 2010

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition.

scientific article

Real-Time PCR: an Effective Tool for Measuring Transduction Efficiency in Human Hematopoietic Progenitor Cells

scientific article published on 2 December 2004

Retroviral Vector Production by Transient Transfection

article

Retroviral Vectors for Gene Transfer

article

Selenomethionine or methylseleninic acid inhibits mutagenesis of a reporter gene in mouse bone marrow.

scientific article published in February 2010

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction

scientific article published on 20 December 2018

Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis

scientific article

Soypeptide lunasin in cytokine immunotherapy for lymphoma.

scientific article published on 22 December 2013

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

scientific article published on 6 January 2017

Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma

scientific article published on 26 August 2020

TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

scientific article

TRTH-14. TARGETING CHK1 AND AKT CROSSTALK IN MUTANT P53 PEDIATRIC GLIOBLASTOMA.

scientific article published on 31 May 2017

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

scientific article published on June 2011

Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways

scientific article published on 27 March 2013

The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches

scientific article published on 26 December 2016

The Role of MDM2 in Promoting Genome Stability versus Instability.

scientific article published on 23 October 2017

The Xpc gene markedly affects cell survival in mouse bone marrow

scientific article published on 16 April 2009

Transduction of Cell Lines by Retroviral Vectors

scientific article published on 01 April 2008

Transduction of Primary Hematopoietic Cells by Retroviral Vectors

scientific article published on 01 April 2008

Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

scientific article

UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system

scientific article published on 17 January 2008

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

scientific article published on 4 October 2011

c-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

scientific article published on October 2009

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