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List of works by Dirk De Ruysscher

18FDG-PET based radiation planning of mediastinal lymph nodes in limited disease small cell lung cancer changes radiotherapy fields: a planning study

scientific article

18FDG-PET-CT in the follow-up of non-small cell lung cancer patients after radical radiotherapy with or without chemotherapy: an economic evaluation

scientific article published in January 2010

3D dose delivery verification using repeated cone-beam imaging and EPID dosimetry for stereotactic body radiotherapy of non-small cell lung cancer

article by Wouter van Elmpt et al published February 2010 in Radiotherapy and Oncology

A 2-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated With Development of Erectile Dysfunction Following Radiation Therapy for Prostate Cancer ⬇️

scientific article published on September 26, 2012

A Validated Prediction Model for Overall Survival From Stage III Non-Small Cell Lung Cancer: Toward Survival Prediction for Individual Patients

scientific article published on 30 April 2015

A closer look at the safety and effectiveness of modern PORT in stage III-N2 non-small cell lung cancer

scientific article published on June 2017

A longitudinal evaluation of partial lung irradiation in mice by using a dedicated image-guided small animal irradiator

scientific article published on 4 September 2014

A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer

scientific article published on 20 December 2011

A prospective study comparing the predictions of doctors versus models for treatment outcome of lung cancer patients: a step toward individualized care and shared decision making

scientific article published on 17 May 2014

A systematic literature review of the clinical and cost-effectiveness of hadron therapy in cancer

scientific article

A systematic methodology review of phase I radiation dose escalation trials

scientific article published on 24 March 2010

Accuracy of deformable image registration for contour propagation in adaptive lung radiotherapy

scientific article published on 18 October 2013

Accurate automatic delineation of heterogeneous functional volumes in positron emission tomography for oncology applications

scientific article published on 29 January 2010

An “in silico” clinical trial comparing free breathing, slow and respiration correlated computed tomography in lung cancer patients

Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: prognostic value of positron emission tomography in early-stage non-small cell lung cancer

scientific article

Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy

scientific article published in December 2017

CT characteristics allow identification of patient-specific susceptibility for radiation-induced lung damage

scientific article published on 6 August 2015

Can we optimize chemo-radiation and surgery in locally advanced stage III non-small cell lung cancer based on evidence from randomized clinical trials? A hypothesis-generating study

scientific article published on July 2009

Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients

scientific article published on 14 September 2013

Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer

scientific article (publication date: October 2013)

Charged particles in radiotherapy: A 5-year update of a systematic review ⬇️

scientific article published on February 10, 2012

Clinical Controversies: Proton Therapy for Thoracic Tumors ⬇️

scientific article published on April 1, 2013

Clustering of multi-parametric functional imaging to identify high-risk subvolumes in non-small cell lung cancer

scientific article

Combined use of hyperthermia and radiation therapy for treating locally advanced cervical cancer

scientific article

Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma

scientific article

Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma

scientific article

Comparing the Outcomes of Stereotactic Ablative Radiotherapy and Non-Stereotactic Ablative Radiotherapy Definitive Radiotherapy Approaches to Thoracic Malignancy: A Systematic Review and Meta-Analysis

scientific article published on 15 December 2017

Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: a meta-analysis

scientific article published on 03 September 2009

Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer

scientific article (published 2009-07-08)

Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer

scientific article

Conducting radiogenomic research--do not forget careful consideration of the clinical data

scientific article

Consensus Statement on Proton Therapy in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer

scientific article published on 23 January 2016

Correlation of intra-tumour heterogeneity on 18F-FDG PET with pathologic features in non-small cell lung cancer: a feasibility study

scientific article published on 6 March 2008

Critical review of PET-CT for radiotherapy planning in lung cancer

scientific article

Current clinical evidence for proton therapy

scientific article

D7-05: FDG-PET allows identification of radioresistant areas within the tumor during and after radiation treatment of NSCLC

Data-Based Radiation Oncology: Design of Clinical Trials in the Toxicity Biomarkers Era.

scientific article

Development and external validation of prognostic model for 2-year survival of non-small-cell lung cancer patients treated with chemoradiotherapy

scientific article

Development and validation of a prognostic model using blood biomarker information for prediction of survival of non-small-cell lung cancer patients treated with combined chemotherapy and radiation or radiotherapy alone (NCT00181519, NCT00573040, an

scientific article published in October 2010

Development of a multicomponent prediction model for acute esophagitis in lung cancer patients receiving chemoradiotherapy

scientific article

Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients

scientific article published in December 2010

Do we have enough evidence to implement particle therapy as standard treatment in lung cancer? A systematic literature review

scientific article published on 12 January 2010

Dose-intensified accelerated vindesine-ifosfamide-cisplatin (VIP) chemotherapy followed by high-dose accelerated hyperfractionated radiotherapy in patients with pathologically proven stage IIIB non-small cell lung cancer: a feasibility study

scientific article

Dyspnea evolution after high-dose radiotherapy in patients with non-small cell lung cancer

scientific article published on 13 November 2008

Early CT and FDG-metabolic tumour volume changes show a significant correlation with survival in stage I–III small cell lung cancer: A hypothesis generating study ⬇️

scientific article published on May 14, 2011

Early versus late chest radiotherapy in patients with limited-stage small cell lung cancer

scientific article

Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis

scientific article published on 28 September 2010

Effects of radiotherapy planning with a dedicated combined PET-CT-simulator of patients with non-small cell lung cancer on dose limiting normal tissues and radiation dose-escalation: A planning study

article by Dirk De Ruysscher et al published October 2005 in Radiotherapy and Oncology

Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer

scientific article

Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer

scientific article (published 2006-07-19)

Establishment of a Radiogenomics Consortium

scientific article

European Organisation for Research and Treatment of Cancer recommendations for planning and delivery of high-dose, high-precision radiotherapy for lung cancer

scientific article

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung cancer

scientific article published on 27 June 2017

FDG and Beyond

scientific article published on January 2016

FDG for dose painting: a rational choice

scientific article published on 17 June 2010

First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II.

scientific article published on 24 March 2010

Follow-up with 18FDG-PET-CT after radical radiotherapy with or without chemotherapy allows the detection of potentially curable progressive disease in non-small cell lung cancer patients: a prospective study

scientific article

Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer

scientific article published on 26 May 2013

HI-CHART: a phase I/II study on the feasibility of high-dose continuous hyperfractionated accelerated radiotherapy in patients with inoperable non-small-cell lung cancer

scientific article published on 26 November 2007

High-dose re-irradiation following radical radiotherapy for non-small-cell lung cancer

scientific article

How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons

scientific article

Hyperfractionated or accelerated radiotherapy in lung cancer: an individual patient data meta-analysis

scientific article

Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters

scientific article published on 14 September 2013

Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: a prospective validation

scientific article published on 22 July 2011

Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)Fluorodeoxyglucose-PET-CT scan

scientific article

Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis

scientific article published on 12 August 2015

In Regard to Redmond et al

scientific article published on 7 August 2017

In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18F]HX4 and [18F]FDG-PET/CT imaging

scientific article published on 14 October 2014

Increased (18)F-deoxyglucose uptake in the lung during the first weeks of radiotherapy is correlated with subsequent Radiation-Induced Lung Toxicity (RILT): a prospective pilot study

scientific article published on 3 February 2009

Increased therapeutic ratio by 18FDG-PET CT planning in patients with clinical CT stage N2-N3M0 non-small-cell lung cancer: a modeling study

scientific article published in March 2005

Individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage III NSCLC: a prospective population-based study

scientific article published on 17 November 2011

Individualized Radical Radiotherapy of Non–Small-Cell Lung Cancer Based on Normal Tissue Dose Constraints: A Feasibility Study

Individualized hypo/hyperfractionated radiotherapy for non-small cell lung cancer

scientific article published on April 2014

Intra-patient variability of tumor volume and tumor motion during conventionally fractionated radiotherapy for locally advanced non-small-cell lung cancer: A prospective clinical study

article by Geert Bosmans et al published November 2006 in International Journal of Radiation Oncology Biology Physics

Is high-dose stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) overkill? A systematic review

scientific article

Is selective nodal irradiation in non-small cell lung cancer still safe when using IMRT? Results of a prospective cohort study

scientific article published on 21 November 2016

Is there a different dose-effect relation between the primary tumor and involved lymph nodes in locally advanced non-small-cell lung cancer? A hypothesis-generating study

scientific article published on 26 February 2017

Literature-based recommendations for treatment planning and execution in high-dose radiotherapy for lung cancer

scientific article published on May 2004

Long-term survival of stage T4N0-1 and single station IIIA-N2 NSCLC patients treated with definitive chemo-radiotherapy using individualised isotoxic accelerated radiotherapy (INDAR).

scientific article published on 17 January 2014

Lung function evaluation before surgery in lung cancer patients: how are recent advances put into practice? A survey among members of the European Society of Thoracic Surgeons (ESTS) and of the Thoracic Oncology Section of the European Respiratory So

Mature results of a phase II trial on individualised accelerated radiotherapy based on normal tissue constraints in concurrent chemo-radiation for stage III non-small cell lung cancer ⬇️

scientific article published on May 18, 2012

Metabolic control probability in tumour subvolumes or how to guide tumour dose redistribution in non-small cell lung cancer (NSCLC): an exploratory clinical study

scientific article

Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival: a meta-analysis

scientific article published on 04 October 2013

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy

scientific article

Nintedanib reduces radiation-induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator

scientific article published on 31 July 2017

Nodal recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: Incidence and proposed risk factors

scientific article

Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer: a phase II trial

scientific article

Optimal design and patient selection for interventional trials using radiogenomic biomarkers: A REQUITE and Radiogenomics consortium statement

scientific article

Optimal gating compared to 3D and 4D PET reconstruction for characterization of lung tumours

scientific article

Optimal gross tumor volume definition in lung-sparing intensity modulated radiotherapy for pleural mesothelioma: an in silico study

scientific article published on 12 October 2016

Optimized local therapy for locally advanced non-small cell lung cancer

scientific article published on July 2017

PD3-1-3: Zirconium-89 labeled Cetuximab: A very promising imaging probe to monitor and quantify EGFR expression non-invasively in vivo

PET imaging of hypoxia using [18F]HX4: a phase I trial

scientific article

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

scientific article published on 21 December 2016

PET scans in radiotherapy planning of lung cancer

scientific article published on 23 July 2010

PET scans in radiotherapy planning of lung cancer

scientific article published on 15 September 2011

PET-CT in Radiotherapy for Lung Cancer ⬇️

scientific article published on January 1, 2011

PET-CT-based auto-contouring in non-small-cell lung cancer correlates with pathology and reduces interobserver variability in the delineation of the primary tumor and involved nodal volumes

scientific article published on 29 March 2007

Particle therapy in lung cancer: where do we stand?

scientific article published on 15 January 2008

Particle therapy versus conventional radiotherapy for lung cancer

scientific article published on 9 June 2015

Particle therapy versus conventional radiotherapy for lung cancer

scientific article (published 2009-10-07)

Phase III Study of Surgery Versus Definitive Concurrent Chemoradiotherapy Boost in Patients With Resectable Stage IIIA(N2) and Selected IIIB Non-Small-Cell Lung Cancer After Induction Chemotherapy and Concurrent Chemoradiotherapy (ESPATUE).

scientific article published on 2 November 2015

Phased versus midventilation attenuation-corrected respiration-correlated PET for patients with non-small cell lung cancer

scientific article published on 13 November 2009

Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients

scientific article published in September 2004

Postoperative radiotherapy for lung cancer: Is it worth the controversy?

scientific article

Predicting Outcome by Images? ⬇️

scientific article published on May 28, 2013

Predicting outcomes in radiation oncology--multifactorial decision support systems

scientific article

Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT.

scientific article published on 25 August 2017

Prediction of residual metabolic activity after treatment in NSCLC patients

scientific article published on October 2010

Prophylactic cranial irradiation for patients with lung cancer

scientific article published in July 2016

Proposals for the M-descriptors of the Eight TNM Classification for Non-Small Cell Lung Cancer: Are More Data Needed?

scientific article published in March 2016

Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers

scientific article

Proton therapy in clinical practice: current clinical evidence

scientific article

Quantification of CT-assessed radiation-induced lung damage in lung cancer patients treated with or without chemotherapy and cetuximab

scientific article published on 23 September 2015

Quantification of radiation-induced lung damage with CT scans: the possible benefit for radiogenomics

scientific article

Quantitative radiomics studies for tissue characterization: a review of technology and methodological procedures

scientific article published on 12 December 2016

Radical Treatment of Non–Small-Cell Lung Cancer Patients with Synchronous Oligometastases: Long-Term Results of a Prospective Phase II Trial (Nct01282450) ⬇️

scientific article published on October 1, 2012

Radical treatment of synchronous oligometastases from NSCLC.

scientific article published on 24 October 2016

Radiogenomics: radiobiology enters the era of big data and team science

scientific article

Radiotherapy and Immunotherapy: Improving Cancer Treatment through Synergy

scientific article published on 04 September 2015

Radiotherapy in combination with immune checkpoint inhibitors

scientific article published on 12 January 2017

Regional variability in radiation-induced lung damage can be predicted by baseline CT numbers

scientific article

Reirradiation of recurrent node-positive non-small cell lung cancer after previous stereotactic radiotherapy for stage I disease : A multi-institutional treatment recommendation

scientific article published on 19 April 2017

Response Assessment Using 18F-FDG PET Early in the Course of Radiotherapy Correlates with Survival in Advanced-Stage Non–Small Cell Lung Cancer ⬇️

scientific article published on August 9, 2012

Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: a prospective clinical study

scientific article

Selective nodal irradiation on basis of (18)FDG-PET scans in limited-disease small-cell lung cancer: a prospective study

scientific article published on 24 September 2009

Should patient setup in lung cancer be based on the primary tumor? An analysis of tumor coverage and normal tissue dose using repeated positron emission tomography/computed tomography imaging

scientific article

Small lesion, severe consequences. An intriguing ventilation-perfusion scintigraphy

scientific article

Standard of care in high-dose radiotherapy for localized non-small cell lung cancer.

scientific article

State of the Art Radiation Therapy for Lung Cancer 2012: A Glimpse of the Future ⬇️

scientific article published on July 31, 2012

Strategies for improving outcomes in NSCLC: a look to the future

scientific article published on 08 September 2013

Survival Prediction in Lung Cancer Treated with Radiotherapy: Bayesian Networks vs. Support Vector Machines in Handling Missing Data

scholarly article published December 2009

Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy

scientific article published on 22 December 2011

The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer

scientific article

The European Respiratory Society and European Society of Thoracic Surgeons clinical guidelines for evaluating fitness for radical treatment (surgery and chemoradiotherapy) in patients with lung cancer

scientific article published on 27 May 2009

The Optimal Local Treatment of Stage IIIA-N2 NSCLC: Is the Issue Finally Settled?

scientific article published in March 2016

The PET-boost randomised phase II dose-escalation trial in non-small cell lung cancer ⬇️

scientific article published on April 6, 2012

The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

scientific article

The cost-effectiveness of particle therapy in non-small cell lung cancer: exploring decision uncertainty and areas for future research

scientific article published on 29 March 2010

The current status of FDG-PET in tumour volume definition in radiotherapy treatment planning

scientific article

The importance of patient characteristics for the prediction of radiation-induced lung toxicity

scientific article

The integration of PET-CT scans from different hospitals into radiotherapy treatment planning

scientific article

The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer

scientific article

The promise of multiparametric imaging in oncology: how do we move forward?

scientific article published on 29 March 2016

The use of FDG-PET to target tumors by radiotherapy

scientific article published on 30 August 2010

Therapeutic implications of molecular imaging with PET in the combined modality treatment of lung cancer ⬇️

scientific article published on February 12, 2011

Time trends in nodal volumes and motion during radiotherapy for patients with stage III non-small-cell lung cancer

scientific article published on 8 November 2007

Time trends in the maximal uptake of FDG on PET scan during thoracic radiotherapy. A prospective study in locally advanced non-small cell lung cancer (NSCLC) patients

Timing of chest radiotherapy in patients with limited stage small cell lung cancer: a systematic review and meta-analysis of randomised controlled trials

scientific article published on 21 May 2007

Total gross tumor volume is an independent prognostic factor in patients treated with selective nodal irradiation for stage I to III small cell lung cancer

scientific article published on 29 November 2012

Transition from a simple to a more advanced dose calculation algorithm for radiotherapy of non-small cell lung cancer (NSCLC): implications for clinical implementation in an individualized dose-escalation protocol

scientific article published on 11 August 2008

Treatment with curative intent of stage III non-small cell lung cancer patients of 75 years: a prospective population-based study

scientific article published on 4 July 2011

Tumor delineation based on time-activity curve differences assessed with dynamic fluorodeoxyglucose positron emission tomography-computed tomography in rectal cancer patients

scientific article published on 14 June 2008

Tumor infiltrating lymphocytes in lung cancer: a new prognostic parameter

scientific article published on August 2016

Tumor volume combined with number of positive lymph node stations is a more important prognostic factor than TNM stage for survival of non-small-cell lung cancer patients treated with (chemo)radiotherapy

scientific article published on 24 September 2007

Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review

scientific article

Tumour delineation and cumulative dose computation in radiotherapy based on deformable registration of respiratory correlated CT images of lung cancer patients

scientific article published on 23 October 2007

Variations in target volume definition for postoperative radiotherapy in stage III non-small-cell lung cancer: analysis of an international contouring study

scientific article

Volume or position changes of primary lung tumor during (chemo-)radiotherapy cannot be used as a surrogate for mediastinal lymph node changes: the case for optimal mediastinal lymph node imaging during radiotherapy

scientific article published on 24 April 2010

Volumetric CT-based segmentation of NSCLC using 3D-Slicer

scientific article

What to choose as radical local treatment for lung metastases from colo-rectal cancer: surgery or radiofrequency ablation?

scientific article published on 13 June 2013

[¹⁸F]fluorodeoxyglucose uptake patterns in lung before radiotherapy identify areas more susceptible to radiation-induced lung toxicity in non-small-cell lung cancer patients

scientific article published on 29 September 2010

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