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List of works by Cynthia Hawkins

A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours

scientific article published on 6 June 2009

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

scientific article

A comprehensive review of paediatric low-grade diffuse glioma: pathology, molecular genetics and treatment

scientific article published on 25 March 2017

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

scientific article

A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes

scientific article published on 4 December 2013

A pilot study of fat allograft transplantation in immunocompetent rabbits for potential neurosurgical applications

scientific article published on 4 December 2009

A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma

scientific article

AT-03ATYPICAL TERATOID RHABDOID TUMORS IN THE FIRST YEAR OF LIFE: SHOULD WE TREAT?

scientific article published on 30 May 2016

AT-11CRIBRIFORM NEUROEPITHELIAL TUMOR (CRINET): MOLECULAR CHARACTERIZATION OF A SMARCB1-DEFICIENT NON-RHABDOID TUMOR WITH FAVORABLE LONG-TERM OUTCOME.

scientific article published on 30 May 2016

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

scientific article

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients ⬇️

scientific article published on December 12, 2011

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors

scientific article published on 15 October 2014

An integrative molecular and genomic analysis of pediatric hemispheric low-grade gliomas: an update

scientific article published on 20 September 2016

An intracranial leiomyosarcoma in a child with neurofibromatosis type 1.

scientific article published in July 2009

An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN)

scientific article published on 10 April 2015

Angiography-negative primary central nervous system vasculitis in children: a newly recognized inflammatory central nervous system disease

scientific article

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

scientific article

Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke ⬇️

scientific article published on November 22, 2012

Astrocytic-inducible nitric oxide synthase in the ischemic developing human brain

scientific article published on 25 October 2006

Atypical Teratoid Rhabdoid Tumor Diagnosis after Partial Resection of Dysembryoplastic Neuroepithelial Tumor: Case Report and Review of the Literature

scientific article published on 16 March 2016

Atypical teratoid or rhabdoid tumors: improved outcome with high-dose chemotherapy

scientific article published on July 2010

Atypical teratoid rhabdoid tumor in the first year of life: the Canadian ATRT registry experience and review of the literature

scientific article published on 19 January 2017

Aurora Kinase B Is a Potential Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma ⬇️

scientific article published on October 11, 2012

B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma ⬇️

scientific article published on December 12, 2012

BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.

scientific article

BT-02FUNCTIONALLY-DEFINED THERAPEUTIC TARGETS IN DIFFUSE INTRINSIC PONTINE GLIOMA.

scientific article published on 21 April 2015

Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy

scientific article

Becker muscular dystrophy caused by an intronic mutation reducing the efficiency of the splice donor site of intron 26 of the dystrophin gene

scientific article published on 18 February 2009

Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells

scientific article published on 8 October 2011

Brain biopsy in children with primary small-vessel central nervous system vasculitis

scientific article

C-kit expression and mutational analysis in medulloblastoma

scientific article published on 30 July 2004

Carriers and patients with muscle-eye-brain disease can be rapidly diagnosed by enzymatic analysis of fibroblasts and lymphoblasts

scientific article published on 19 January 2006

Characterization and transformation potential of "Synthetic" astrocytes differentiated from murine embryonic stem cells

scientific article published in March 2008

Clinical Neuropathology practice guide 6-2013: morphology and an appropriate immunohistochemical screening panel aid in the identification of synovial sarcoma by neuropathologists

scientific article

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

scientific article published on 10 March 2016

Clinical implications of medulloblastoma subgroups: incidence of CSF diversion surgery

scientific article published on 19 December 2014

Clinical, EEG, MRI, MEG, and surgical outcomes of pediatric epilepsy with astrocytic inclusions versus focal cortical dysplasia

scientific article

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

scientific article

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

Congenital glioblastoma: a clinicopathologic and genetic analysis

scientific article published on 23 April 2007

Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

scientific article published on 6 July 2016

Cribriform neuroepithelial tumour: novel clinicopathological, ultrastructural and cytogenetic findings ⬇️

scientific article published on September 15, 2011

DETAILED MOLECULAR CHARACTERISATION OF DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIES THREE MOLECULAR SUBGROUPS AND A NOVEL CANCER DRIVER, ACVR1.

scientific article published in July 2014

Detecting Stem Cell Marker Expression Using the NanoString nCounter System

scientific article published on 01 January 2019

Developmental stage-specific transformation of neural progenitors

scientific article published on 13 December 2013

Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques

scientific article published on 20 November 2007

Diagnostic yield of brain biopsies in children presenting to neurology

scientific article published on 11 January 2008

Differential patterns of metastatic dissemination across medulloblastoma subgroups

scientific article published on 8 December 2017

Differential transformation capacity of neuro-glial progenitors during development

scientific article published on 13 August 2013

Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent

scientific article published on 25 February 2014

EPN-38RELAPSE PATTERNS IN PEDIATRIC INTRACRANIAL EPENDYMOMA: A CANADIAN EXPERIENCE.

scientific article published on 30 May 2016

EPND-08. EPIGENETIC H3K27ME3 DEREGULATION IN PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS.

scientific article

EZH2 expression is a prognostic factor in childhood intracranial ependymoma: a Canadian Pediatric Brain Tumor Consortium study

scientific article published on 13 January 2015

Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm

scientific article published on 4 December 2017

Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor

scientific article published in February 2009

Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. Laboratory investigation

scientific article

Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades.

scientific article published in January 2003

Favorable outcome with conservative treatment for children with low grade brainstem tumors

scientific article published on 25 May 2011

Favorable survival and metabolic outcome for children with diencephalic syndrome using a radiation-sparing approach

scientific article published on 12 November 2013

Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas

scientific article published in December 2010

Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors

scientific article

FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells

scientific article published on July 2013

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

scientific article (publication date: June 2015)

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

scientific article

GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model

scholarly article

GLI2 Is a Potential Therapeutic Target in Pediatric Medulloblastoma ⬇️

scientific article published on June 1, 2011

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

scientific article published on 24 May 2011

Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium

scientific article published on 15 January 2014

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas

scientific article

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

scientific article (publication date: May 2014)

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

scientific article published on 30 April 2013

Germline and somatic mutations in STXBP1 with diverse neurodevelopmental phenotypes

scientific article published on 18 December 2017

Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies ⬇️

scientific article published on 07 December 2012

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma

scientific article published on 16 June 2017

HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES.

scientific article published on 30 May 2016

HG-80ISSUES IN THE MANAGEMENT OF CHILDREN WITH BRAIN TUMORS AND BIALLELIC MISMATCH GENE REPAIR DEFICIENCY SYNDROME.

scientific article published on 30 May 2016

HGG-18. GLIOMAS IN ADOLESCENTS AND YOUNG ADULTS SHARE SEVERAL MOLECULAR FEATURES WITH THEIR PEDIATRIC COUNTERPARTS.

scientific article published on 31 May 2017

Hemorrhagic presentations of cerebellar pilocytic astrocytomas in children resulting in death: report of 2 cases

scientific article published on 18 December 2015

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme ⬇️

scientific article published on January 17, 2011

High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan

scientific article published on 8 August 2015

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications

scientific article

Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma

scientific article

Identification of a cancer stem cell in human brain tumors ⬇️

scientific article (publication date: 15 September 2003)

Identification of complex genomic rearrangements in cancers using CouGaR

scientific article

Identification of human brain tumour initiating cells

scientific article (publication date: 18 November 2004)

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article

Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature

scientific article

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

scientific article published on 26 September 2017

Intellectual Outcome in Molecular Subgroups of Medulloblastoma

scientific article published on 9 August 2016

International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor classification and grading

scientific article published on 10 September 2014

Intracerebral malignant peripheral nerve sheath tumor in a child with neurofibromatosis Type 1 and middle cerebral artery aneurysm treated with endovascular coil embolization

scientific article

Intracranial dissection mimicking transient cerebral arteriopathy in childhood arterial ischemic stroke

scientific article

JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma

scientific article published on 24 March 2016

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

scientific article

LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM.

scientific article published on 30 May 2016

LG-19IMMUNOHISTOCHEMISTRY IS HIGHLY SENSITIVE AND SPECIFIC FOR THE DETECTION OF BRAF V600E STATUS IN PEDIATRIC LOW-GRADE GLIOMA.

scientific article published on 30 May 2016

LG-50MULTIPLEX DETECTION OF PEDIATRIC LOW GRADE GLIOMA SIGNATURE FUSION AND DUPLICATION TRANSCRIPTS USING THE NANOSTRING NCOUNTER SYSTEM.

scientific article published on 30 May 2016

LGG-10. EPIGENETIC/GENETIC/MORPHOLOGIC ANALYSES REVEAL CLINICAL/PROGNOSTIC INSIGHT OF PEDIATRIC LOW GRADE GLIOMAS

LGG-16. LOCATION AND HISTOLOGY DICTATE THE LIKELIHOOD OF MOLECULAR EVENTS IN PEDIATRIC LOW-GRADE GLIOMA.

scientific article

LGG-18. MOLECULAR ALTERATIONS PREDICT RESPONSE TO CHEMOTHERAPY AND OUTCOME OF PEDIATRIC LOW-GRADE GLIOMA.

scientific article published on 31 May 2017

Lethal Disorder of Mitochondrial Fission Caused by Mutations in DNM1L.

scientific article published on 26 January 2016

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos

scientific article

Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner

scientific article published on 30 August 2013

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

scientific article published on November 2016

MB-107REST ELEVATION UNRESTRAINS SHH SIGNALING IN MEDULLOBLASTOMA.

scientific article published on 30 May 2016

MEDU-12. CD271 (P75NTR) AS A NOVEL DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR SHH MEDULLOBLASTOMA.

scientific article published on 31 May 2017

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

scientific article

Management and outcome of chordomas in the pediatric population: The Hospital for Sick Children experience and review of the literature

scientific article published on 30 August 2016

Management of Acute Myeloblastic Leukemia in a Child With Biallelic Mismatch Repair Deficiency

scientific article published on 12 August 2015

Massive CAG repeat expansion and somatic instability in maternally transmitted infantile spinocerebellar ataxia type 7.

scientific article published in February 2015

Medulloblastoma subgroup-specific outcomes in irradiated children: who are the true high-risk patients?

scientific article

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Milder phenotype of congenital muscular dystrophy in a novel POMT1 mutation ⬇️

scientific article published on May 1, 2012

Mitochondrial POLG related disorder presenting prenatally with fetal cerebellar growth arrest

scientific article published on 25 March 2018

Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups

scientific article published on 21 October 2014

Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors

scientific article published on 5 December 2011

Multicystic demyelinating myelopathy: widening spectrum of pediatric aquaporin-4 autoimmunity

scientific article published on March 2014

NCO-10INTELLECTUAL OUTCOME IN MOLECULAR SUBGROUPS OF MEDULLOBLASTOMA.

scientific article

Neoadjuvant chemotherapy reduces blood loss during the resection of pediatric choroid plexus carcinomas

scientific article published on May 2015

Nerve resection and re-location may relieve causalgia: a case report

scientific article

Overgrowth with increased proliferation of fibroblast and matrix metalloproteinase activity related to reduced TIMP1: A newly recognized syndrome? ⬇️

scientific article published on September 10, 2012

PNR-32UPDATE OF DIAGNOSTICS OF PRIMITIVE NEUROECTODERMAL TUMOURS OF THE CNS - NEUROPATHOLOGICAL RE-EVALUATION OF 99 CASES.

scientific article published on 30 May 2016

PT-01THE IMPACT OF INITIAL RADIATION IN INFANTS AND THE RE-IRRADIATION OF RECURRENT DISEASE ON THE SURVIVAL OF EPENDYMOMA PATIENTS AT THE HOSPITAL FOR SICK CHILDREN, TORONTO.

scientific article published in November 2014

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge

scientific article published on February 2014

Pathological Findings of a Subependymal Giant Cell Astrocytoma Following Treatment With Rapamycin

scientific article published on 14 June 2015

Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma

scientific article (publication date: 2015)

Patients with primary brain tumors as organ donors: case report and review of the literature

scientific article published on July 2004

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

scientific article published on 2 August 2017

Pediatric high-grade glioma: biologically and clinically in need of new thinking

scientific article

Pediatric low-grade gliomas: implications of the biologic era.

scientific article published on 28 September 2016

Pediatric sinonasal undifferentiated carcinoma: case report and literature review ⬇️

scientific article published on November 1, 2010

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children

scientific article

Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma

scientific article published on 5 March 2012

Phenotypic and genotypic characterisation of biallelic mismatch repair deficiency (BMMR-D) syndrome

scientific article published on 13 April 2015

Pilomyxoid astrocytoma in a patient with neurofibromatosis

scientific article

Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

scientific article published on 8 September 2015

Post mortem examinations in diffuse intrinsic pontine glioma: challenges and chances

scientific article published on 16 May 2010

Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors

scientific article published on 27 November 2013

Postmortem Vascular Pathology in PHACES Syndrome: A Case Report ⬇️

scientific article published on August 17, 2012

Primary central nervous system sarcomas in children: clinical, radiological, and pathological features ⬇️

scientific article published on October 22, 2003

Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG ⬇️

scientific article published on September 8, 2011

Profound clinical and radiological response to BRAF inhibition in a 2-month-old diencephalic child with hypothalamic/chiasmatic glioma

scientific article published on 11 July 2016

Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma

scientific article published on 24 April 2017

RNAseq analysis for the diagnosis of muscular dystrophy

scientific article published on 8 December 2015

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis ⬇️

scientific article

Rare Presentation of Supratentorial Primitive Neuroectodermal Tumors Mimicking Bifocal Germ Cell Tumors: 2 Case Reports

scientific article published in August 2015

Rasmussen's encephalitis: advances in management and patient outcomes

scientific article

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor

scientific article

Reirradiation in patients with diffuse intrinsic pontine gliomas: The Canadian experience

scientific article

Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma

scientific article

Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance

scientific article published on 3 April 2015

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Substrate reduction therapy in juvenile GM2 gangliosidosis

scientific article

Successful treatment of primary intracranial sarcoma with the ICE chemotherapy regimen and focal radiation in children

scientific article published on 20 November 2015

Supratentorial ependymoma in children: To observe or to treat following gross total resection? ⬇️

scientific article published on 02 March 2011

Survival and functional outcome of childhood spinal cord low-grade gliomas. Clinical article

scientific article published in September 2009

Sustained Response to Targeted Therapy in a Patient With Disseminated Anaplastic Pleomorphic Xanthoastrocytoma

scientific article published in December 2017

Synchronous glioblastoma and medulloblastoma in a child with mismatch repair mutation

scientific article published on 21 August 2015

TB-08MECHANISMS OF IMMUNE RESISTANCE IN PEDIATRIC POSTERIOR FOSSA TUMORS.

scientific article

TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors

scientific article published on 22 March 2010

Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma

scientific article published on 31 August 2016

Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells

scientific article

Temporal lobe surgery for intractable epilepsy in children: an analysis of outcomes in 126 children

scientific article

The diagnosis of spinal tumors: established and emerging methods

scientific article published on 02 February 2012

The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience

scientific article

The role of telomere maintenance in the spontaneous growth arrest of pediatric low-grade gliomas

scientific article published in February 2006

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

scientific article published on 20 July 2017

Treatment of small vessel primary CNS vasculitis in children: an open-label cohort study ⬇️

scientific article published on November 1, 2010

Two different STAT1 gain-of-function mutations lead to diverse IFN-γ-mediated gene expression

article

Tyrosine kinase expression in pediatric high grade astrocytoma

scientific article

Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations

scientific article published on 8 February 2010

Vascularity and angiogenesis as predictors of growth in optic pathway/hypothalamic gliomas

scientific article published in May 2006

Viruses and human brain tumors: cytomegalovirus enters the fray

scientific article

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

scientific article published on 8 February 2010

X-linked inhibitor of apoptosis protein expression after ischemic injury in the human and rat developing brain

scientific article published in January 2009

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification

scientific article published on 20 December 2016

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