List of works - David Harrich

A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.

scientific article

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors

scientific article published on 16 October 2019

A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes

scientific article

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells

scientific article

A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex.

scientific article

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids

scientific article published on 23 March 2020

An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV.

scientific article

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.

scientific article published on 02 September 2009

Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models

scientific article published on 06 October 2020

Binding of the eukaryotic translation elongation factor 1A with the 5'UTR of HIV-1 genomic RNA is important for reverse transcription

scientific article published on 6 August 2015

Cell factors stimulate human immunodeficiency virus type 1 reverse transcription in vitro

scientific article

Defective Interfering Particles with Broad-Acting Antiviral Activity for Dengue, Zika, Yellow Fever, Respiratory Syncytial and SARS-CoV-2 Virus Infection

scientific article published in 2022

Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein, Nullbasic, in Human T Cells.

scientific article

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

scientific article

Evaluation of polycaprolactone matrices for sustained vaginal delivery of nevirapine in the prevention of heterosexual HIV transmission

scientific article published on 27 May 2014

Evolutionary Interpretations of Nicotinic Acetylcholine Receptor Targeting Venom Effects by a Clade of Asian Viperidae Snakes

scientific article published on 11 May 2020

Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort

scientific article

HIV type 1 inhibition by protein kinase C modulatory compounds

scientific article published on September 2006

HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

scientific article published on 27 March 2018

HIV-1 replication from after cell entry to the nuclear periphery

scientific article published on May 2007

Human immunodeficiency virus type 1 protease regulation of tat activity is essential for efficient reverse transcription and replication

scientific article

Human immunodeficiency virus type 1 reverse transcription is stimulated by tat from other lentiviruses.

scientific article published on September 2002

Human immunodeficiency virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells

scientific article

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

scientific article

Isolated HIV-1 core is active for reverse transcription.

scientific article published on 24 October 2007

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus ⬇️

scientific article published on May 1, 2012

Kunjin Virus Replicon Vectors for Human Immunodeficiency Virus Vaccine Development

scientific article (publication date: July 2003)

Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity

scientific article

Maturation of the HIV reverse transcription complex: putting the jigsaw together

scientific article

Mechanistic aspects of HIV-1 reverse transcription initiation

scientific article

Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking

scientific article

Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6.

scientific article published on 24 June 2013

Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication

scholarly article by Daniel J Rawle et al published 27 March 2019 in Journal of Virology

Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription

scientific article

Potent inhibition of HIV-1 replication by a Tat mutant

scientific article

Protein methylation is required to maintain optimal HIV-1 infectivity

scientific article

RETRACTED ARTICLE: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication

retracted paper

RNA glycosidase and other agents target Tat to inhibit HIV-1 transcription.

scientific article published on 20 March 2018

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

scientific article

Retraction Note to: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication.

scientific article published on 10 November 2016

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.

scientific article

SerpinB2 is an inducible host factor involved in enhancing HIV-1 transcription and replication

scientific article published on 21 August 2006

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

scientific article published on 05 July 2016

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

scientific article (publication date: December 2015)

Strand transfer and elongation of HIV-1 reverse transcription is facilitated by cell factors in vitro

scientific article

Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

scientific article published on 27 August 2019

Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

scientific article published on 2 June 2014

Tat-Based Therapies as an Adjuvant for an HIV-1 Functional Cure

scientific article published on 08 April 2020

The HIV-1 Tat protein stimulates reverse transcription in vitro

scientific article published on 01 September 2007

The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

scientific article

The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production

scientific article

The first strand transfer reaction of HIV-1 reverse transcription is more efficient in infected cells than in cell-free natural endogenous reverse transcription reactions

scientific article published on February 2003

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

scientific article

The unexpected roles of eukaryotic translation elongation factors in RNA virus replication and pathogenesis

scientific article published on June 2013

The unique features of SARS-CoV-2 transmission: Comparison with SARS-CoV, MERS-CoV and 2009 H1N1 pandemic influenza virus

scientific article published on 18 September 2020

Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating

article

Treponema pallidum, Lipoproteins, and Synthetic Lipoprotein Analogues Induce Human Immunodeficiency Virus Type 1 Gene Expression in Monocytes via NF- B Activation ⬇️

scientific article published on April 1, 1998

Will diverse Tat interactions lead to novel antiretroviral drug targets?

scientific article

eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency

article

List of works by David Harrich

A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors

A mutant Tat protein inhibits infection of human cells by strains from diverse HIV-1 subtypes

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells

A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex.

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids

An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV.

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.

Assessing the Binding of Venoms from Aquatic Elapids to the Nicotinic Acetylcholine Receptor Orthosteric Site of Different Prey Models

Binding of the eukaryotic translation elongation factor 1A with the 5'UTR of HIV-1 genomic RNA is important for reverse transcription

Cell factors stimulate human immunodeficiency virus type 1 reverse transcription in vitro

Defective Interfering Particles with Broad-Acting Antiviral Activity for Dengue, Zika, Yellow Fever, Respiratory Syncytial and SARS-CoV-2 Virus Infection

Differential Effects of Strategies to Improve the Transduction Efficiency of Lentiviral Vector that Conveys an Anti-HIV Protein, Nullbasic, in Human T Cells.

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

Evaluation of polycaprolactone matrices for sustained vaginal delivery of nevirapine in the prevention of heterosexual HIV transmission

Evolutionary Interpretations of Nicotinic Acetylcholine Receptor Targeting Venom Effects by a Clade of Asian Viperidae Snakes

Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort

HIV type 1 inhibition by protein kinase C modulatory compounds

HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

HIV-1 replication from after cell entry to the nuclear periphery

Human immunodeficiency virus type 1 protease regulation of tat activity is essential for efficient reverse transcription and replication

Human immunodeficiency virus type 1 reverse transcription is stimulated by tat from other lentiviruses.

Human immunodeficiency virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

Isolated HIV-1 core is active for reverse transcription.

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus ⬇️

Kunjin Virus Replicon Vectors for Human Immunodeficiency Virus Vaccine Development

Kunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity

Maturation of the HIV reverse transcription complex: putting the jigsaw together

Mechanistic aspects of HIV-1 reverse transcription initiation

Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking

Overexpression of PRMT6 does not suppress HIV-1 Tat transactivation in cells naturally lacking PRMT6.

Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication

Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription

Potent inhibition of HIV-1 replication by a Tat mutant

Protein methylation is required to maintain optimal HIV-1 infectivity

RETRACTED ARTICLE: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication

RNA glycosidase and other agents target Tat to inhibit HIV-1 transcription.

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

Retraction Note to: A U5 repressor of reverse transcription is required for optimal HIV-1 infectivity and replication.

Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription.

SerpinB2 is an inducible host factor involved in enhancing HIV-1 transcription and replication

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

Strand transfer and elongation of HIV-1 reverse transcription is facilitated by cell factors in vitro

Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.

Tat-Based Therapies as an Adjuvant for an HIV-1 Functional Cure

The HIV-1 Tat protein stimulates reverse transcription in vitro

The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production

The first strand transfer reaction of HIV-1 reverse transcription is more efficient in infected cells than in cell-free natural endogenous reverse transcription reactions

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

The unexpected roles of eukaryotic translation elongation factors in RNA virus replication and pathogenesis

The unique features of SARS-CoV-2 transmission: Comparison with SARS-CoV, MERS-CoV and 2009 H1N1 pandemic influenza virus

Toward the "unravelling" of HIV: Host cell factors involved in HIV-1 core uncoating

Treponema pallidum, Lipoproteins, and Synthetic Lipoprotein Analogues Induce Human Immunodeficiency Virus Type 1 Gene Expression in Monocytes via NF- B Activation ⬇️

Will diverse Tat interactions lead to novel antiretroviral drug targets?

eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency