Search filters

List of works by Kathrin Maedler

Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.

scientific article published on 9 February 2018

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

scientific journal article

An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis

scientific article published on 24 March 2018

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

scientific article

Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry

scientific article published on 4 May 2015

Beta cells in type 2 diabetes - a crucial contribution to pathogenesis

scientific article published on 19 April 2007

COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways

scientific article

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

scientific article published in February 2009

CXCL10- a path to β-cell death

scientific article published on November 2009

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

scientific article published on 14 October 2020

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

scientific article

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass

scientific article

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

scientific article published on 29 January 2017

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

scientific article published on 8 January 2016

Efficient gene delivery and silencing of mouse and human pancreatic islets

scientific article

Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase.

scientific article published on 17 June 2016

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

scientific article published on 08 July 2020

Erratum to: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

scientific article published on September 2015

Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

scientific article

Expression of Fas but not Fas ligand on fetal pig beta cells

scientific article published in September 2004

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways

scientific article

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

scientific article

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression

scientific article published on 5 July 2013

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

scientific article published on 8 February 2008

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

scientific article published in July 2004

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

scientific article

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

scientific article published on 05 May 2018

Identification of ALOX5 as a gene regulating adiposity and pancreatic function

scientific article

Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

scientific article

Imaging of the β-cells of the islets of Langerhans

Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

scientific article

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

scientific article

Interleukin-1 beta targeted therapy for type 2 diabetes

scientific article published on September 2009

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

scientific article

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

scientific article published on 23 March 2018

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2

scientific article published on 18 February 2016

Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance

scientific article published on 01 January 2020

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

scientific article published in October 2006

Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study

scientific article published on 13 February 2020

Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

scientific article published on 22 May 2020

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

scientific article published on 16 March 2014

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

scientific article published on 6 April 2016

Macrophage-associated pro-inflammatory state in human islets from obese individuals

scientific article published on 02 December 2019

Manganese-mediated MRI signals correlate with functional β-cell mass during diabetes progression

scientific article published on 24 March 2015

Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin

scientific article published on 22 October 2019

Mechanisms of beta-cell death in type 2 diabetes.

scientific article

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

scientific article published in March 2003

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes

scientific article published on 05 December 2019

Neratinib protects pancreatic beta cells in diabetes

scientific article published on 01 November 2019

Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization

scientific article

Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations

scientific article

Pancreatic β-cell rescue in diabetes by targeting Merlin

scientific article published on 16 February 2017

Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies

scientific article

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes

scientific article published on 8 January 2013

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

scientific article published on 25 April 2009

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

retracted scientific article

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

scientific article published on 21 December 2016

Rettet die Beta-Zelle: Neue Therapieansätze für Diabetes

STRIPAK Is a Regulatory Hub Initiating Hippo Signaling

scientific article published on 15 February 2020

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

scientific article published on 05 April 2017

Sulfonylurea induced beta-cell apoptosis in cultured human islets

scientific article published on 13 October 2004

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

scientific article published on 04 September 2012

TCF7L2 splice variants have distinct effects on beta-cell turnover and function

scientific article published on 28 February 2011

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

scientific article published on 12 May 2014

TLR4 triggered complex inflammation in human pancreatic islets

scientific article published on 01 October 2018

TOSO promotes β-cell proliferation and protects from apoptosis

scientific article published on 17 August 2012

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization

scientific article published on 30 April 2013

The Fas pathway is involved in pancreatic beta cell secretory function

scholarly article

The Hippo signaling pathway in pancreatic β-cells: functions and regulations

scientific article

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion

scientific article

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

scientific article published on 31 January 2008

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

scientific article published on 7 November 2007

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells

scientific article

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

article

XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model

scientific article published on 23 March 2010

mTORC in β cells: more Than Only Recognizing Comestibles

scientific article

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

scientific article published on 20 December 2017

mTORC1 and IRS1: Another Deadly Kiss

scientific article published on 03 August 2018

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function

scientific article published on 23 February 2018

β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype

scientific article published on 21 June 2016

Paulina is supported by:

About Paulina

Help