List of works - John D Pediani

A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.

scientific article published on 18 May 2017

A general method to quantify ligand-driven oligomerization from fluorescence-based images

scientific article published on 20 May 2019

Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular gland

scientific article published on 01 December 1992

Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy.

scientific article published on 6 February 2012

Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t

scientific article published on 01 December 2020

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).

scientific article published on 31 August 2011

Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting

scientific article

Dimerization of alpha1-adrenoceptors.

scientific article published in November 2004

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.

scientific article

Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A ⬇️

scientific article published on September 9, 2011

High-affinity interactions between human alpha1A-adrenoceptor C-terminal splice variants produce homo- and heterodimers but do not generate the alpha1L-adrenoceptor.

scientific article

Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.

scientific article published on 2 March 2012

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET

scientific article

Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

scientific article published on March 2011

Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes

scientific article published on 15 March 2017

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

scientific article published on 12 March 2012

Nucleotide‐evoked calcium signals and anion secretion in equine cultured epithelia that express apical P2Y2 receptors and pyrimidine nucleotide receptors ⬇️

scientific article published on June 1, 1998

P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells.

scientific article published on April 1999

Potassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitro

scientific article published on 01 September 1989

Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells.

scientific article published on 13 June 2013

Real-time monitoring of redox changes in the mammalian endoplasmic reticulum ⬇️

scientific article published on June 21, 2011

Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis

scientific article published on 30 March 2015

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.

scientific article published on July 2014

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

scientific article published on 9 October 2017

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.

scientific article published on 19 April 2017

Sr2+ can become incorporated into an agonist-sensitive, cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium.

scientific article published on August 1995

The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis

scientific article published on 01 July 1991

The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland

scientific article published on 01 February 1995

The effects of removing external sodium upon the control of potassium (86Rb+) permeability in the isolated human sweat gland

scientific article published on 01 September 1990

The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

scientific article published on 16 February 2009

The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.

scientific article

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

scientific article published on 26 August 2013

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

scientific article published on 25 April 2012

Visualization of the activation of the histamine H3 receptor (H3R) using novel Fluorescence Resonance Energy Transfer Biosensors and their potential application to the study of H3R pharmacology.

scientific article published on 26 April 2018

Why fluorescent probes for endoplasmic reticulum are selective: an experimental and QSAR-modelling study

scientific article published on 01 December 2003

List of works by John D Pediani

A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.

A general method to quantify ligand-driven oligomerization from fluorescence-based images

Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular gland

Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy.

Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).

Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting

Dimerization of alpha1-adrenoceptors.

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.

Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A ⬇️

High-affinity interactions between human alpha1A-adrenoceptor C-terminal splice variants produce homo- and heterodimers but do not generate the alpha1L-adrenoceptor.

Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET

Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

Nucleotide‐evoked calcium signals and anion secretion in equine cultured epithelia that express apical P2Y2 receptors and pyrimidine nucleotide receptors ⬇️

P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells.

Potassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitro

Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells.

Real-time monitoring of redox changes in the mammalian endoplasmic reticulum ⬇️

Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.

Sr2+ can become incorporated into an agonist-sensitive, cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium.

The cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosis

The effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular gland

The effects of removing external sodium upon the control of potassium (86Rb+) permeability in the isolated human sweat gland

The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.

The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

Visualization of the activation of the histamine H3 receptor (H3R) using novel Fluorescence Resonance Energy Transfer Biosensors and their potential application to the study of H3R pharmacology.

Why fluorescent probes for endoplasmic reticulum are selective: an experimental and QSAR-modelling study