List of works by Jun Ninomiya-Tsuji

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

scientific article published on 6 March 2003

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

scientific article published on 22 September 2005

Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells

scientific article

Activated macrophage survival is coordinated by TAK1 binding proteins

scientific article

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

scientific article published on 24 June 2004

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

scientific article published on 7 February 2018

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

scientific article

Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

scientific article published on 13 February 2012

Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

scientific article published on 6 September 2017

Essential function for the kinase TAK1 in innate and adaptive immune responses

scientific article published on 25 September 2005

Generation of a conditional mutant allele for Tab1 in mouse

scientific article published on August 2008

Inhibition of autophagy by TAB2 and TAB3

scientific article

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

scientific article

Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis

scientific article

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation

scientific article published on 16 January 2004

Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation

scientific article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

scientific article published on 11 April 2019

Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1.

scientific article

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways

scientific article

Osmotic stress blocks NF-kappaB-dependent inflammatory responses by inhibiting ubiquitination of IkappaB.

scientific article

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

scientific article

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

scientific article

Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.

scientific article

Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

scientific article

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)

scientific article

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

scientific article

SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans

scientific article

TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

scientific article

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB

scientific article

TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms

scientific article

TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation

scientific article published on 2 February 2007

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.

scientific article published on June 2016

TAK1 binding protein 2 is essential for liver protection from stressors

scientific article (publication date: 2014)

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus.

scientific article published on 16 March 2016

TAK1 is a central mediator of NOD2 signaling in epidermal cells

scientific article published on 26 October 2007

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.

scientific article published on 30 January 2006

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

scientific article

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

scientific article (publication date: 7 February 2003)

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.

scientific article published on 28 August 2006

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

scientific article

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

scientific article published on February 2014

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

scientific article published on 7 July 2008

TAK1 regulates resident macrophages by protecting lysosomal integrity

scientific article published on 09 February 2017

TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling

scientific article published on October 2008

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

scientific article published in May 2005

TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium

scientific article published on 20 September 2010

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells

scientific article published on April 2013

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development

scientific article

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

scientific journal article

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

scientific article

Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway

scientific article

Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression

scientific article

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK

scientific article

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