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List of works by Bjorn C. Knollmann

A "rough" journey to the sarcoplasmic reticulum--implications of altered calsequestrin trafficking for cardiac arrhythmia.

scientific article published on 11 July 2010

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel

scientific article published on 28 March 2018

A genetic framework for improving arrhythmia therapy.

scientific article published on February 2008

A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention

scientific article published on 30 November 2020

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

scientific article

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

scientific journal article

Accelerated junctional rhythm and nonalternans repolarization lability precede ventricular tachycardia in Casq2-/- mice.

scientific article

Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.

scientific article published on 7 January 2013

Accentuated vagal antagonism paradoxically increases ryanodine receptor calcium leak in long-term exercised Calsequestrin2 knockout mice

scientific article published on 10 October 2017

Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution

scientific article published on 08 September 2006

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.

scientific article

Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.

scientific article published on 2 December 2014

Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release

scientific article published on 09 October 2008

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes

scientific article published on 05 August 2019

Antagonism of the Thromboxane-Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

scientific article published on 30 October 2019

Arrhythmia Protection in Hypokalemia: A Novel Role of Ca2+-Activated K+ Currents in the Ventricle

scientific article published on 11 September 2015

Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis

scientific article published on 01 February 2019

Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia

scientific article published on 01 April 2020

Azithromycin Causes a Novel Proarrhythmic Syndrome

scientific article published in April 2017

Calcium in atrial fibrillation - pulling the trigger or not?

scientific article published on 20 October 2014

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

scientific article published on 01 July 2017

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

scientific article published on 27 March 2019

Calsequestrin 2 and arrhythmias

scientific article

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

scientific article

Calsequestrin 2 deletion shortens the refractoriness of Ca²⁺ release and reduces rate-dependent Ca²⁺-alternans in intact mouse hearts

scientific article published on 29 September 2011

Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia

scientific article

Cardiac calsequestrin: the new kid on the block in arrhythmias.

scientific article published on 26 June 2009

Cardiac regulatory mechanisms: from cardiac mechanisms to novel therapeutic approaches

scientific article published on 01 July 2020

Cardiac regulatory mechanisms: new concepts and challenges.

scientific article published in June 2017

Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling

scientific article published on 04 October 2019

Carvedilol tweaks calcium release to ease arrhythmias ⬇️

scientific article published on 04 August 2011

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

scientific journal article

Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes

scientific article

Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia

scientific article published on 11 July 2019

Clinical phenotype of HCN4-related sick sinus syndrome

scientific article published on 14 February 2017

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.

scientific article

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

scientific article published on 09 April 2016

Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias

scientific article published on 05 April 2020

Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell type specific expression of Casq2 in the CPVT2 phenotype

scientific article published on 14 February 2018

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart

scientific article

Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin

scientific article

Dantrolene: from better bacon to a treatment for ventricular fibrillation.

scientific article published on 08 January 2014

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension

scientific article

Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

scientific article published on 01 December 2020

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase

scientific article published on 15 June 2006

Differential rate responses to nicotine in rat heart: evidence for two classes of nicotinic receptors.

scientific article published in June 2002

Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy

scientific article

Dispersion of ventricular repolarization in the voltage domain

scientific article published on 01 January 1998

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

scientific article published on 21 February 2014

Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia.

scientific article published on 31 December 2012

Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.

scientific article published on 12 July 2011

Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

scientific article published on 13 August 2019

Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial

scientific article published on 10 May 2017

Essential Role of Calmodulin in RyR Inhibition by Dantrolene

scientific article published on 28 April 2015

Exercise after myocardial infarction improves contractility and decreases myofilament Ca2+ sensitivity

scientific article published on 01 April 2007

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers

scientific article published on 22 August 2005

Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.

scientific article published on 6 February 2003

Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput?

scientific article published on May 2013

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

scientific article

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

scientific article

Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia

scientific article

Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments

scientific article published on 26 March 2013

Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.

scientific article published on 7 October 2011

Gauging the risk of arrhythmic death by common genetic variants: resurgence of the sinister QT

scientific article published on 01 June 2011

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

scientific article published on 2 May 2018

Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients.

scientific article published on 4 December 2003

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.

scientific article

Genetics of sudden cardiac death syndromes

scientific article

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1.

scientific article published on 06 June 2020

Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full

scientific article published on 01 December 2015

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

scientific article published on 4 December 2017

Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2.

scientific article published on 7 March 2015

In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning.

scientific article published on 9 November 2015

Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS

scientific article published on 22 May 2020

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

scientific article published on 22 January 2010

Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?

scientific article published on March 2013

Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

scientific article

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

scientific article published on 23 August 2016

Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?

scientific article published on 27 August 2013

Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current

scientific journal article

Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart

scientific article

MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

scientific article published on 30 March 2020

Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

scientific article

Mechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia

scientific article published on 01 September 2011

Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy

scientific article published on 27 August 2011

Microelectrode study of the genesis of the monophasic action potential by contact electrode technique

scientific article published on 01 December 2002

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes

scientific article

Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice

scientific article published on 26 July 2007

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia

scientific article published on 02 March 2020

Multiple modes of ryanodine receptor 2 inhibition by flecainide.

scientific article

Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.

scientific article published on 29 May 2012

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

scientific article

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy

scientific article published in November 2017

Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction

scientific article published on 06 April 2013

Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation

scientific article published on June 2016

New roles of calsequestrin and triadin in cardiac muscle.

scientific article published on 18 May 2009

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

scientific article

Oxidized CaMKII: a "heart stopper" for the sinus node?

scientific article published on 25 July 2011

Pacing lightly: optogenetics gets to the heart ⬇️

scientific article published on 01 November 2010

Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle.

scientific article

Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

scientific article published on March 2013

Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice

scientific article published on 13 November 2018

Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome

scientific article published on 18 April 2019

Personal digital assistant-based drug reference software as tools to improve rational prescribing: benchmark criteria and performance

scientific article

Power and pitfalls of using transgenic mice to optimize therapy for CPVT: A need for prospective placebo-controlled clinical trials in genetic arrhythmia disorders ⬇️

scientific article published on July 29, 2010

Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2 knockout mice

scientific article

RYR2 Channel Inhibition Is the Principal Mechanism 0f Flecainide Action in CPVT

scientific article published on 10 December 2020

Ratiometric imaging of calcium during ischemia-reperfusion injury in isolated mouse hearts using Fura-2.

scientific article

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 20 November 2019

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

scientific article

Research priorities in sarcomeric cardiomyopathies

scientific article

Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles.

scientific article published on March 2012

SPEG Kinase: Hitting the Brake in Atrial Fibrillation

scientific article published on 21 September 2020

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

scientific article

Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: risk factor and potential therapeutic target?

scientific article

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G

scientific journal article

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

scientific article published on 8 August 2011

Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts

scientific article published on 03 February 2014

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome.

scientific article

Teaching rational prescribing: a new clinical pharmacology curriculum for medical schools

scientific article published on 22 May 2002

Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models

scientific article published on 23 May 2018

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

scientific article published on 30 July 2019

The beat goes on--driven by a cardiac calcium clock?

scientific article published on 4 March 2008

The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering

scientific journal article

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

scientific article published on 2 October 2017

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies

scientific article published on 29 August 2019

Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias

scientific article published on 8 February 2013

Triadin: the new player on excitation-contraction coupling block.

scientific article published in April 2005

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia

scientific article published on 19 March 2013

Two pools of IRE1α in cardiac and skeletal muscle cells

scientific article published on 03 May 2019

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

scientific article published on 21 February 2019

Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.

scientific article published on 6 November 2012

Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice

scientific article published on 06 December 2018

Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice

scientific article published on 16 February 2018

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