List of works - Hans van Dam

14-3-3ζ turns TGF-β to the dark side

scientific article published on 01 February 2015

ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.

scientific article published on 30 January 2008

Adenovirus E1A down-regulates the EGF receptor via repression of its promoter.

scientific article

Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.

scientific article

BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression.

scientific article

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation.

scientific article

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.

scientific article

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

scientific article published on 18 September 2019

Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells.

scientific article published on June 1991

Control of endothelial sprouting by a Tel–CtBP complex ⬇️

scientific article published on September 12, 2010

Corrigendum: YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.

scientific article published in October 2017

DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.

scientific article

DNA-binding domain of human c-Myc produced in Escherichia coli.

scientific article published on June 1989

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

scientific article (publication date: 30 April 2001)

Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

scientific article published on 12 July 2018

FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

scientific article published on 21 November 2018

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

scientific article

Fas-associated Factor 1 Is a Scaffold Protein That Promotes β-Transducin Repeat-containing Protein (β-TrCP)-mediated β-Catenin Ubiquitination and Degradation ⬇️

scientific article published on June 22, 2012

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.

scientific article

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38

scientific article published on July 2002

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein

scientific article

In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo

scientific article

Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease

scientific article published on 27 July 2005

Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.

scientific article

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

scientific article published on 16 January 2019

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

scientific article published on 21 November 2019

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

scientific article published on 23 November 2017

Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

scientific article

Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products.

scientific article published on July 1995

Molecular insights into tumour metastasis: tracing the dominant events.

scientific article published on 30 December 2016

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

scientific article published on 21 November 2018

RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation ⬇️

scientific article published on May 3, 2012

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

scientific article

Regulation of the TGF-β pathway by deubiquitinases in cancer

scientific article published on 4 May 2016

Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.

scientific article published on 5 June 2008

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif

scientific article

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

scientific article published on 27 August 2012

TGF-β signaling in cancer metastasis.

scientific article published on 28 November 2017

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

scientific article

The regulation of TGF-β/SMAD signaling by protein deubiquitination

scientific article

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

scientific article published on 6 April 2006

Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo

scientific article

Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.

scientific article published in March 2001

Tumor-derived exosomes antagonize innate antiviral immunity

scientific article published on 22 January 2018

Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled

scientific article

Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.

scientific article published on 19 January 2012

Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response

scientific article published on 01 March 1992

VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation ⬇️

scientific article published on 01 February 2020

YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.

scientific article published on 8 May 2017

c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway.

scientific article

List of works by Hans van Dam

14-3-3ζ turns TGF-β to the dark side

ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.

Adenovirus E1A down-regulates the EGF receptor via repression of its promoter.

Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation.

BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β(3) expression.

Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation.

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression

Co-regulated expression of junB and MHC class I genes in adenovirus-transformed cells.

Control of endothelial sprouting by a Tel–CtBP complex ⬇️

Corrigendum: YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.

DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.

DNA-binding domain of human c-Myc produced in Escherichia coli.

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

Fas-associated Factor 1 Is a Scaffold Protein That Promotes β-Transducin Repeat-containing Protein (β-TrCP)-mediated β-Catenin Ubiquitination and Degradation ⬇️

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein

In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo

Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease

Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Key signaling nodes in mammary gland development and cancer: Smad signal integration in epithelial cell plasticity

Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products.

Molecular insights into tumour metastasis: tracing the dominant events.

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation ⬇️

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

Regulation of the TGF-β pathway by deubiquitinases in cancer

Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

TGF-β signaling in cancer metastasis.

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

The regulation of TGF-β/SMAD signaling by protein deubiquitination

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo

Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.

Tumor-derived exosomes antagonize innate antiviral immunity

Ubiquitin-Specific Protease 4 Antagonizes Osteoblast Differentiation Through Dishevelled

Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.

Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response

VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation ⬇️

YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.

c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway.