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List of works by Stefano Morotti

A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research

scientific article published on 20 July 2018

A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources

scientific article published on 27 July 2019

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

scientific article published on 13 January 2014

Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

scientific article published on 04 June 2019

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

scientific article published on August 2015

Bi-directional flow of the funny current (I f ) during the pacemaking cycle in murine sinoatrial node myocytes

Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences

scientific article

Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts

scientific article published on 11 July 2019

Editorial: Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond.

scientific article

Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)].

scientific article published in October 2017

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

scientific article

In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. ⬇️

scientific article published on 7 November 2017

Interplay of voltage and Ca-dependent inactivation of L-type Ca current.

scientific article

Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.

scientific article published in January 2018

Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk

scientific article published on 23 December 2016

Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.

scientific article published on 10 February 2017

Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes

scientific article published on 23 December 2016

Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback

scientific article published on 17 July 2018

Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.

scientific article published on September 2017

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

scientific article published on 24 January 2017

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

scientific article published on 25 February 2015

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