List of works - Joseph Loscalzo

Pulmonary Arterial Hypertension

scientific article published on 01 October 2004

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

scientific article (publication date: 18 May 2010)

Disease networks. Uncovering disease-disease relationships through the incomplete interactome

scientific article published on February 2015

Vascular calcification: pathobiological mechanisms and clinical implications

scientific article published on November 2006

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

scientific article

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

scientific article published on April 10, 2011

Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

scientific article

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

scientific article

Evidence for human lung stem cells

scientific article

MicroRNA-210: A unique and pleiotropic hypoxamir

scientific article published on March 15, 2010

Genetic Misdiagnoses and the Potential for Health Disparities

scientific article

Redox regulation of mitochondrial function

scientific article

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview

scientific article

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

scientific article

MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach

scientific article published on 27 February 2012

Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity

scientific article published on 4 February 2007

Hypoxia: a master regulator of microRNA biogenesis and activity

scientific article published on 24 May 2013

Pathogenic mechanisms of pulmonary arterial hypertension

scientific article published on 20 September 2007

The treatment of hyperhomocysteinemia

scientific article published on January 2009

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

scientific article published on 23 July 2015

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

scientific article published in 2005

Homocysteine trials--clear outcomes for complex reasons

scientific article published on 12 March 2006

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

scientific article published on 22 August 2016

Systems biology and the future of medicine

scientific article

Cyclooxygenase inhibition and cardiovascular risk

scientific article

Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure

scientific journal article

Genetically encoded fluorescent sensors for intracellular NADH detection

scientific article published on October 2011

Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology

scientific article published on June 2004

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

scientific article published on May 2015

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

scientific article published in Nature

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

scientific article published on 27 September 2005

Oxidative risk for atherothrombotic cardiovascular disease

scientific article

Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide

scientific article

Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes

scientific article

RETRACTED: Cardiomyogenesis in the aging and failing human heart

retracted scientific article

High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis

scientific article

Cellular glutathione peroxidase deficiency and endothelial dysfunction

scientific journal article

Serial noninvasive assessment of progressive pulmonary hypertension in a rat model

scientific article

Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction

scientific journal article

Oxidative enzymopathies and vascular disease

scientific article

Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses

scientific article

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice

scientific article

Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis

scientific article

Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification

scientific article published on December 19, 2012

Platelet-monocyte aggregates: bridging thrombosis and inflammation

scientific article published on 01 May 2002

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

scientific article published on July 11, 2012

Cellular Redox State and Endothelial Dysfunction in Mildly Hyperhomocysteinemic Cystathionine β-Synthase–Deficient Mice

scientific article published on January 1, 2002

S-nitrosoprotein formation and localization in endothelial cells

scientific article

Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association

scientific article

Role of oxidative stress and nitric oxide in atherothrombosis

scientific article published on May 2008

List of works by Joseph Loscalzo

Pulmonary Arterial Hypertension

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

Disease networks. Uncovering disease-disease relationships through the incomplete interactome

Vascular calcification: pathobiological mechanisms and clinical implications

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

Evidence for human lung stem cells

MicroRNA-210: A unique and pleiotropic hypoxamir

Genetic Misdiagnoses and the Potential for Health Disparities

Redox regulation of mitochondrial function

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach

Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity

Hypoxia: a master regulator of microRNA biogenesis and activity

Pathogenic mechanisms of pulmonary arterial hypertension

The treatment of hyperhomocysteinemia

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

Homocysteine trials--clear outcomes for complex reasons

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

Systems biology and the future of medicine

Cyclooxygenase inhibition and cardiovascular risk

Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure

Genetically encoded fluorescent sensors for intracellular NADH detection

Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology

SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

Oxidative risk for atherothrombotic cardiovascular disease

Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide

Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes

RETRACTED: Cardiomyogenesis in the aging and failing human heart

High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis

Cellular glutathione peroxidase deficiency and endothelial dysfunction

Serial noninvasive assessment of progressive pulmonary hypertension in a rat model

Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction

Oxidative enzymopathies and vascular disease

Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice

Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis

Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification

Platelet-monocyte aggregates: bridging thrombosis and inflammation

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

Cellular Redox State and Endothelial Dysfunction in Mildly Hyperhomocysteinemic Cystathionine β-Synthase–Deficient Mice

S-nitrosoprotein formation and localization in endothelial cells

Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association

Role of oxidative stress and nitric oxide in atherothrombosis